Relationship between Bcl-2/FasL gene and pathogenesis of endometriosis

Objective To research whether the endometriosis is associated with Bc1-2 and FasL gene.Methods Immunohistochemistry method(streptavidin-peroxidase method)was used to detect the expression of Bcl-2 and FasL gene in 19 specimens of normal endometrium tissue,33 specimens of endometriosis tissue and eutopic endometrium from patients with endometriosis(11 cases).Results The control group:the expression of Bcl-2 and FasL predominated in the glandular cytoplasm and/or on the plasma membrane.The expressions of Bcl-2 in proliferative phase was higher than that in secretory phase significantly(P0.05).The expressions of FasL in proliferative phase was less than that in secretory phase significantly(P0.05).So the expressions of Bcl-2 and FasL obviously cyclic changes throughtout the menstrual cycle in nomal endometrium tissue.2.The endometriosis group:The expressions of Bcl-2 and FasL also predominated in the glandular cytoplasm and/or on the plasma membrane.Both Bcl-2 and FasL expression in proliferative phase was the same as secretory phase(P0.05).So Bcl-2 and FasL expression in adenomyosis had no cyclic change and their staining had remained in the whole menstrual cycle.The expressions of Bcl-2 and FasL in endometriosis was higher than that in normal endometrium significantly(P0.000 1).Conclusion It is suggested that the retrograding of these active anti-apoptotic endometrial cells may play a key role in the pathogenesis of endometriosis.