Highlighting the Role of Prenatally Administered Drugs in the Production of Dental Enamel Defects in Rats by Polarized Light Microscopy

The etiopathogenesis of developmental defects of dental enamel (DDE) is incompletely elucidated, factors acting pre- and postnatally are considered. Amoxicillin and cefaclor are mentioned among the drugs administered in various conditions, with a role in the development of DDE. The objective of the present study was to reproduce DDE in the la-boratory, in rats by administering amoxicillin, ibuprofen and cefaclor. These lesions were subsequently diagnosed using polarized light microscopy. The study was conducted on Wistar rats, which were given prenatally drugs possibly involved in the production of DDE. After macroscopic examination and identification of enamel defects, optical and polarized light microscopy examination was performed. Centralizing the data obtained after this study, it resulted that the group to which cefaclor was administered was the most affected, followed by the group to which amoxicillin was administered in a double dose, the group to which ibuprofen was administered, the group to which amoxicillin was administered in a standard dose and the control group. Following this research, it was concluded that DDE in the form of demineralization were more frequently recorded in the cefaclor and ibuprofen groups, while DDE in the form of hypoplasia were more frequently recorded in the double-dose and standard-dose amoxicillin groups.