Study on the Mechanism of Periplaneta americana Extract to Accelerate Wound Healing after Diabetic Anal Fistula Operation Based on Network Pharmacology
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Abstract
OBJECTIVE: Using network pharmacology research methods to explore the healing mechanism of American cockroach extract to accelerate wound healing after diabetic anal fistula surgery. METHOD: extraction (PAE) for diabetic anal fistula wound were obtained by Venn diagram. These common targets were predicted using the String database for protein-protein interaction (PPI) network and then screening key genes through Cytohubba. Meanwhile, the above targets were analyzed using the DAVID database for gene ontology (GO) enrichment analyses and the Kyoto Encyclopedia of Genes and Genomes (KEGG) path enrichment analyses. RESULTS: A total of 12 chemical components of PAE were obtained by literature retrieval, and 61 therapeutic targets that may accelerate the healing of diabetic anal fistula wounds were predicted by the database. According to PPI network analysis, PAE accelerates wound healing after diabetic anal fistula surgery which may be related to proteins such as AKT1, VEGFA, EGFR, CASP3, STAT3, MAPK1, TNF, JUN, ESR1, and MMP9. GO analysis results show that targets of PAE to promote wound healing were mainly involved in biological processes such as cell proliferation, macrophage differentiation, angiogenesis, and response to hypoxia. KEGG analysis showed that the target genes were mainly concentrated in the PI3K-Akt signaling pathway, HIF-1 signaling pathway, and estrogen signaling pathway. CONCLUSION: extract promoting wound healing.
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References (23)
- doi:10.1161/atvbaha.118.310703 via openalex
- doi:10.1016/j.amjmed.2006.07.009 via openalex
- W2275520312 via openalex
- doi:10.1007/s10151-013-1111-y via openalex
- W2399363537 via openalex
- doi:10.1371/journal.pone.0018996 via openalex
- doi:10.1038/labinvest.2015.160 via openalex
- doi:10.1016/j.pathophys.2011.07.004 via openalex
- doi:10.3390/molecules23010101 via openalex
- doi:10.1530/jme-17-0041 via openalex
- doi:10.1371/journal.pone.0086570 via openalex
- doi:10.2337/db17-1238 via openalex
- doi:10.1016/j.diabres.2019.107843 via openalex
- doi:10.1016/j.jep.2020.113203 via openalex
- doi:10.1021/acs.jmedchem.8b01005 via openalex
- W6694526802 via openalex
- doi:10.1016/j.jdermsci.2019.11.004 via openalex
- doi:10.1016/j.jvs.2018.04.069 via openalex
- doi:10.1038/nbt1007-1110 via openalex
- doi:10.1177/2156587216688597 via openalex
- doi:10.1155/2020/5859023 via openalex
- doi:10.1155/2020/7430968 via openalex
- doi:10.1155/2019/3865121 via openalex
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