The State of Psychoemotional, Cytokine Status and Endothelial Function in Patients with Combined Surgical Pathology of the Abdominal Cavity, True Pelvis and Anterior Abdominal Wall, Depending on the Methodic of Simultaneous Surgical Intervention

The State of Psychoemotional, Cytokine Status and Endothelial Function in Patients with Combined Surgical Pathology of the Abdominal Cavity, True Pelvis and Anterior Abdominal Wall, Depending on the Methodic of Simultaneous Surgical Intervention DOI: https://doi.org/10.6000/2292-2598.2019.07.03.10Keywords: Simultaneous surgical interventions, Fast Track Surgery, proinflammatory cytokines, endothelial function, psychoemotional disorders.Abstract The relevance of the study is in the fact that disorders of vascular and psychoneuroendocrine genesis often accompany surgical diseases, the issue of ensuring patient safety in the perioperative period remains the basic focus of modern clinical surgery. The purpose of the study is to identify changes in the level of pro-inflammatory cytokines and the functional state of the endothelium, and also to establish whether the transferred simultaneous surgical interventions intensified pro-inflammatory cytokines and changes in the functional state of the endothelium. In this article, changes in the level of proinflammatory cytokines and the functional state of the endothelium are studied, as well as the relationship of these changes with comorbid psychoemotional disorders when performing simultaneous surgical interventions by laparoscopic and open methods in combined diseases of organs of the abdominal and anterior abdominal wall. The authors carried out a prospective, randomized controlled study of 586 patients aged 18 to 72 years who underwent planned simultaneous surgical intervention (SSI) with combined diseases of the abdominal cavity, pelvis and anterior abdominal wall. In the course of the comparative analysis, a general trend was established: the simultaneous surgical interventions caused intensification of proinflammatory cytokines and changes in the functional state of the endothelium References Vertkin AL, Rumyantsev MA, Skotnikov AS. Comorbidity. Clin Med 2012; 90(10): 4-11. World Report on Ageing and Health. World Health Organization. [updated 2015 Oct 30; cited 2016 Feb 10]: Available from: http://www.who.int/ageing/events/world-report-2015-launch/en Vertkin AL, Sotnikov AS. Comorbidity. Kazan Med Zh 2014; 95(2): 292-296. DOI: https://doi.org/10.17816/KMJ2084 Kehlet H. The surgical stress response: should it be prevented? Can J Surg 1991; 34(6): 565-567. Kehlet H. Fast-track surgery – an update on physiological are principles to enhance recovery. Langenbecks Arch Surg 2011; 396(5): 585-590. https://doi.org/10.1007/s00423-011-0790-y DOI: https://doi.org/10.1007/s00423-011-0790-y Antipin EE, Uvarov DN, Antipina NP, Nedashkovsky EV, Sovershaeva SL. Early multimodal rehabilitation with abdominal hysterectomy – an impact on the postoperative period. Anesthesiol Reanimatol 2013; 6: 37-41. Antipin EE, Uvarov DN, Svirsky DA, et al. Implementation of the principles of Fast Track in cesarean section. Anesthesiol Reanimatol 2011; 3: 33-36. Krasnov VN. Ethical problems of modern psychiatry. Indep Psychiatr J 2002; 3: 12-17. Talismanov VS, Popkov SV, Zykova SS, Karmanova ОG, Tsaplin GV. Study of the stereoisomeric composition of biologically active substituted 1-[(1,3-dioxolan-4-yl)methyl]-1H-1,2,4-triazoles and 1-[(1,3-dioxolan-4-yl)methyl]-1H-imidazoles by NMR spectroscopy techniques. J Pharm Sci Res 2018; 10: 2041-2044. Burkitbaev ZhK, Raisov SD, Turganbekova AA, et al. HLA Alleles in Kazakhstan and in the global genofund. Gematol Transfusiol 2015; 60(2): 52-56. Kim TK, Yoon JR. Comparison of the neuroendocrine and inflammatory responses after laparoscopic and abdominal hysterectomy. Korean J Anesthesiol 2010; 5(9): 265-269. https://doi.org/10.4097/kjae.2010.59.4.265 DOI: https://doi.org/10.4097/kjae.2010.59.4.265 Jakeways MS, Chadwick SJ, Carli F. A prospective comparison of laparoscopic versus open cholecystectomy. Ann R Coll Surg Engl 1993; 75: 142. Podgoreanu MV, Michelotti GA, Sato Y, et al. Differential cardiac gene expression during cardiopulmonary bypass: ischemia-independent upregulation of proinflammatory genes. J Thorac Cardiovasc Surg 2005; 130: 330-339. https://doi.org/10.1016/j.jtcvs.2004.11.052 DOI: https://doi.org/10.1016/j.jtcvs.2004.11.052 Carli F. Physiologic considerations of enhanced recovery after surgery (ERAS) programs: implications of the stress response. Can J Anesth Can Anesth 2015; 62: 110-119. https://doi.org/10.1007/s12630-014-0264-0 DOI: https://doi.org/10.1007/s12630-014-0264-0 Feldheiser A, Aziz O, Baldini G, et al. Enhanced recovery after surgery (ERAS) for gastrointestinal surgery. Part 2: Consensus statement for anaesthesia practice. Acta Anaesthesiol Scand 2016; 60: 289-334. https://doi.org/10.1111/aas.12651 DOI: https://doi.org/10.1111/aas.12651 Chowdhury AH, Lobo DN. Fluids and gastrointestinal function. Curr Opin Clin Nutr Metab Care 2011; 14: 469-76. https://doi.org/10.1097/MCO.0b013e328348c084 DOI: https://doi.org/10.1097/MCO.0b013e328348c084