To Investigate the Effect of Endometriosis on Intracytoplasmic Sperm Injection Outcome Among Infertile Women without Previous History of Ovarian Surgery

Rohina Gul, Fauzia Tabbasum Cheema, Aliya Muzafar, Aisha Awais, Rameen Nisar, Saba Sardar
2025 · W6982568980
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This retrospective study found that while ovarian endometriosis reduces oocyte retrieval and maturity, it does not significantly impact embryo quality or pregnancy rates in women undergoing IVF/ICSI.

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This retrospective study compared IVF/ICSI outcomes between 90 infertile women with ovarian endometriosis and 90 matched controls without the condition. The research found that while patients with endometriosis had significantly lower antral follicle counts and retrieved fewer mature oocytes, their embryo quality and final pregnancy rates remained comparable to the control group. The authors note that despite reduced oocyte quantity, the presence of ovarian endometriomas did not negatively impact implantation or pregnancy success. This paper is centrally about endometriosis — specifically examining its impact on assisted reproductive technology outcomes in women who have not undergone prior ovarian surgery.

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Abstract

Objective: This study aimed to determine the impact of endometriosis on oocyte maturation in stimulated In-vitro Fertilization/Intra Cytoplasmic Sperm Injection (IVF/ICSI) outcomes. Study type, settings & duration: This retrospective study was conducted at Hameed Latif Hospital, Lahore from March 2021 to March 2023. Methodology: About 180 women were included in this study. All the study subjects were categorized into two groups in equal, where Group A presented with ovarian endometriosis and Group B presented women without endometriosis. Infertility parameters in both groups were same like age, body mass index (BMI), and infertility duration. Outcome parameters (ovarian reserve, fertilization rate, embryo quality, implantation rate and pregnancy outcomes) were compared in both groups. Results: The mean age was 38 years in both groups. In group A, BMI and the Antral Follicle Count was lower as compared to group B. (p-value =0.04) The number of oocytes retrieved, matured, and fertilized was higher in group B (14±5.31, 13±4.60, 12.5±4.79) as compared to group A (5±2.52, 4.83±2.40, 3.66±1.03). All the variables were statistically significant with the p-value <0.05. The pregnancy rate in Group A was 30% and in Group B, it was 29%. Conclusion: Oocyte number and quality are affected by endometriosis. However, ovarian endometrioma does not affect the embryo quality and the outcome of pregnancy.
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Pakistan Journal of Medical Research (Apr 2025) To Investigate the Effect of Endometriosis on Intracytoplasmic Sperm Injection Outcome Among Infertile Women without Previous History of Ovarian Surgery Abstract Objective: This study aimed to determine the impact of endometriosis on oocyte maturation in stimulated In-vitro Fertilization/Intra Cytoplasmic Sperm Injection (IVF/ICSI) outcomes. Study type, settings & duration: This retrospective study was conducted at Hameed Latif Hospital, Lahore from March 2021 to March 2023. Methodology: About 180 women were included in this study. All the study subjects were categorized into two groups in equal, where Group A presented with ovarian endometriosis and Group B presented women without endometriosis. Infertility parameters in both groups were same like age, body mass index (BMI), and infertility duration. Outcome parameters (ovarian reserve, fertilization rate, embryo quality, implantation rate and pregnancy outcomes) were compared in both groups. Results: The mean age was 38 years in both groups. In group A, BMI and the Antral Follicle Count was lower as compared to group B. (p-value =0.04) The number of oocytes retrieved, matured, and fertilized was higher in group B (14±5.31, 13±4.60, 12.5±4.79) as compared to group A (5±2.52, 4.83±2.40, 3.66±1.03). All the variables were statistically significant with the p-value <0.05. The pregnancy rate in Group A was 30% and in Group B, it was 29%. Conclusion: Oocyte number and quality are affected by endometriosis. However, ovarian endometrioma does not affect the embryo quality and the outcome of pregnancy.

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endometriosisendometriomainfertility

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