Administration of a gonadotropin-releasing hormone agonist during pregnancy: follow-up of 28 pregnancies exposed to triptoreline

Elefant E, E Elefant, B Biour, Biour B, Blumberg-Tick J, J Blumberg-Tick, C Roux, Roux C, F. Thomas, Thomas F
Fertility and sterility · 1995 · vol. 63(5) , pp. 1111–3 · doi:10.1016/s0015-0282(16)57557-8 · PMID:7720926
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This prospective follow-up of 28 pregnancies exposed to triptoreline, primarily for endometriosis or IVF, found no teratogenic or fetal toxic effects among newborns after inadvertent administration during the first twenty weeks.

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Abstract

OBJECTIVE: To evaluate the teratogenic or fetal risk of a long-acting GnRH agonist (GnRH-a) triptoreline acetate (Decapeptyl; Ipsen-Biotech, Inc., Paris, France), inadvertently administrated in the first weeks of pregnancy. DESIGN: Prospective follow-up of exposed pregnancies and case reports. SETTING: Teratology information service of a public hospital and pharmacovigilance department of the firm. PATIENTS: Inadvertent pregnant women receiving a treatment, mainly for endometriosis or IVF. INTERVENTIONS: Case by case, individual estimations of the risks have been provided. MAIN OUTCOME MEASURE: Each pregnancy issue has been analyzed. RESULTS: No teratogenic or fetal toxic effect has been noted. CONCLUSION: No specific hazard has been observed among newborns after inadvertent exposures to a GnRH-a during the first 20 weeks of pregnancy.

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Condition tags

endometriosis

MeSH descriptors

Maternal-Fetal Exchange Maternal-Fetal Exchange Triptorelin Pamoate Abnormalities, Drug-Induced Abnormalities, Drug-Induced Female Female Fetal Death Fetal Death Fetal Death Humans Humans Infant, Newborn Infant, Newborn Male Male Pregnancy Pregnancy Prospective Studies Prospective Studies

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