TGF-beta stimulation of endometrial and breast-cancer cell growth
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Abstract
Growth of the human endometrial carcinoma Ishikawa cell line was stimulated by transforming growth factor-beta1 when cultured in serum-containing and chemically defined culture medium. This response was not unique to endometrial carcinoma cells, as the breast-cancer cell line, T47-D, was similarly stimulated by TGF-beta 1. TGF-beta 1 stimulated growth of MCF-7 breast-cancer cells in chemically defined medium but inhibited growth of this cell line in serum-containing medium. The data provide a demonstration of a positive growth response to TGF-beta 1 in oestrogen-receptor-positive cells and do not support the hypothesis that this growth factor is simply a negative growth regulator in epithelial-cancer cell lines.
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- europepmc
- last seen: 2026-09-27T09:11:36.575535+00:00
- pubmed
- last seen: 2026-05-13T22:11:49.821429+00:00
- unpaywall
- last seen: 2026-10-02T06:31:42.897446+00:00
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Courtesy of the U.S. National Library of Medicine
Courtesy of the U.S. National Library of Medicine