Energy metabolism of the human fallopian tube

I A Brewis, Ian A. Brewis, R.M.L. Winston, R M Winston, Henry J. Leese, H J Leese
Journal of reproduction and fertility · 1992 · vol. 95(1) , pp. 257–262 · doi:10.1530/jrf.0.0950257 · PMID:1320696 · W1996852982
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Analysis of human oviductal mucosa reveals that glucose serves as a major metabolic fuel, supported by high hexokinase activity and oxygen consumption stimulated by glucose.

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Abstract

The consumption of oxygen (QO2), the production of lactate and the profile of four key metabolic enzymes were measured in small samples of human oviductal mucosa (endosalpinx) removed at surgery. The QO2 in the absence of substrate was 3.4 microliters O2 (mg dry wt)-1 h-1, a value typical of quiescent tissue. The QO2 was stimulated by glucose, but diminished by glutamine and acetoacetate. Tissue lactate production was low and not increased by glucose. Hexokinase had the highest activity of the enzymes measured, followed by 2-oxoglutarate dehydrogenase; 6-phosphofructokinase and glycogen phosphorylase had low activities. The data are consistent with the proposition that glucose is a major metabolic fuel for human endosalpinx.

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MeSH descriptors

Energy Metabolism Fallopian Tubes Acetoacetates Acetoacetates Culture Techniques Energy Metabolism Fallopian Tubes Fallopian Tubes Female Glucose Glucose Glutamine Glutamine Hexokinase Hexokinase Humans Ketoglutarate Dehydrogenase Complex Ketoglutarate Dehydrogenase Complex Lactates Lactates

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SciLite annotations

organisms 3
human human human
chemicals 8
oxygen lactate glucose glutamine acetoacetate lactate glucose glucose

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