Reproduction and gynaecological manifestations in women with primary Sjögren's syndrome: a case‐control study

Haga HJ, H J Haga, C Gram Gjesdal, Clara Gram Gjesdal, Gjesdal CG, Irgens LM, L M Irgens, Lorentz M. Irgens, Monika Østensen, M Ostensen, Ostensen M
Scandinavian journal of rheumatology · 2005 · vol. 34(1) , pp. 45–48 · doi:10.1080/03009740510017959 · PMID:15903025 · W2140658643
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Women with primary Sjögren's syndrome experience more gynaecological issues like amenorrhoea, menorrhagia, vaginal dryness, and endometriosis compared to controls.

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Abstract

BACKGROUND: The impact of primary Sjögren's syndrome (pSS) on reproduction and gynaecological manifestations has seldom been explored. AIM OF STUDY: Assess gynaecological aspects, gynaecological interventions, and use of contraceptives in a population of pSS-patients versus controls. METHODS: In a case-control study, 58 pSS-patients and 157 controls answered a self-administered questionnaire, covering demographic data, reproductive events, gynaecological problems, and gynaecological interventions. RESULTS: Significantly more patients than controls reported episodes of amenorrhoea lasting for more than 3 months, and more patients suffered from menorrhagia/metrorrhagia compared with controls (54.5% versus 35.7%; p = 0.012). Complaints of vaginal dryness were common among the patients (52.9% versus 28.3%; p = 0.005). Endometriosis was reported to occur more frequently in the patients (8.5% versus 2.1%; p = 0.03), and 6.3% of pSS-patients reported having undergone surgical intervention for endometriosis versus 0.7% of the controls (p = 0.009). Positive information about surgery for endometriosis correlated with the presence of the autoantibodies anti-SSA (r = 0.322; p = 0.008) and anti-SSB (r = 0.313; p = 0.01). Among the pSS-patients, 5.9% had chosen not to have children due to the disease, but there was no indication of reduced fertility as judged by the number of pregnancies. CONCLUSION: Patients with pSS reported more gynaecological problems than controls, including vaginal sicca symptoms, endometriosis, several episodes of amenorrhoea, and menorrhagia/metrorrhagia.

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Condition tags

endometriosis

MeSH descriptors

Genital Diseases, Female Menstruation Disturbances Sjogren's Syndrome Adult Aged Amenorrhea Amenorrhea Case-Control Studies Endometriosis Endometriosis Female Genital Diseases, Female Humans Menorrhagia Menorrhagia Menstruation Disturbances Metrorrhagia Metrorrhagia Middle Aged Sjogren's Syndrome

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Cited by (9)

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