Mefenamic acid treatment to ward follicles development and progesterone level

Abstract Mefenamic acid is anti-inflammation non-steroid, which can hamper prostaglandin synthesis in the body tissue by hampering the siklooxigen enzyme. The purpose of this research is to find out the influence of Mefenamic acid toward the follicles development and progesterone level. This research is an experimental laboratory method. The subject of the research divided into five groups randomly selected and have been homogenized — one group as a control group and others as an experimental group with various dosages of Mefenamic acid treatment. The data is analyzed using a one-way Anova test. The results of this research are confirmed the significant difference of Grafian follicles, yellowish corpus luteum and progesterone level as the influence of Mefenamic acid. While there was no significant difference in tertiary follicles development. The decrease of corpus luteum is caused by Mephenamic acid activity to hamper the prostaglandin synthesis in the body tissue by hampering the siklooxigen enzyme. The prostaglandin can make follicles swelling and cause follicles fracture and make ovulation. The granulosis cell will make corpus luteum, which secreted progesterone hormone. Mefenamic acid was proven to avoid ovulation that blocked the formation of yellowish corpus luteum resulting in decreased blood progesterone level.