Predictors of Unacceptable Pain With and Without Low Inflammation Over 5 Years in Early Rheumatoid Arthritis - an Inception Cohort Study

Abstract Objectives: Pain is a major symptom in patients with rheumatoid arthritis (RA). In early RA, pain is usually due to synovitis, but can also persist despite effective anti-inflammatory treatment. The objective of this study was to investigate the pain course over time, and predictors of unacceptable pain and unacceptable pain with low inflammation, in patients with early RA.Methods: An inception cohort of 232 patients with early RA, recruited in 1995-2005, was followed in a structured program for 5 years. Pain was assessed using a visual analogue scale (VAS; 0-100). Unacceptable pain was defined as VAS pain>40 based on the patient acceptable symptom state (PASS), and low inflammation as CRP<10 mg/l. Baseline predictors of unacceptable pain were evaluated using logistic regression analysis. Results: Pain improved significantly during the first 6 months, but then remained basically unchanged. Thirty-four percent of the patients had unacceptable pain 5 years after inclusion. Baseline predictors of unacceptable pain after 5 years were lower swollen joint counts [Odds ratio (OR) 0.71 per standard deviation (95% confidence interval (CI) 0.51–0.99)], and higher VAS for pain and global assessment of disease activity. Unacceptable pain with low inflammation after 5 years was negatively associated with anti-CCP antibodies [OR 0.50 (95% CI 0.22–0.98)].Conclusion: Over one third of the patients had unacceptable pain 5 years after inclusion. Extensive synovitis was associated with reduced risk of unacceptable pain at 5 years, likely due to positive effects of treatment on pain related to inflammation. Non-inflammatory long-lasting pain appears to be a greater problem in anti-CCP negative patients.