Transcranial Direct Current Stimulation Does Not Increase Auditory False Perceptions in Healthy Participants

Transcranial Direct Current Stimulation Does Not Increase Auditory False Perceptions in Healthy Participants | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 26 March 2025 V1 Latest version Share on Transcranial Direct Current Stimulation Does Not Increase Auditory False Perceptions in Healthy Participants Authors : Tine Tronrud 0009-0004-5976-3413 [email protected] , Isabella Kusztrits 0000-0003-3678-2860 , Julien Laloyaux , and Marco Hirnstein Authors Info & Affiliations https://doi.org/10.22541/au.174301760.03306436/v1 Published European Journal of Neuroscience Version of record Peer review timeline 260 views 112 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract not-yet-known not-yet-known not-yet-known unknown We aimed to test a neurocognitive model positing that auditory hallucinations arise from a hyperactive left temporoparietal cortex and a hypoactive left dorsolateral prefrontal cortex. Specifically, 104 healthy individuals completed a signal detection task that induces auditory false perceptions whilst receiving transcranial direct current stimulation (tDCS). All participants were tested twice, once with real and once with sham tDCS. However, in half of the participants, the electrode montage mimicked the hypertemporal/hypofrontal model (anode over temporoparietal cortex, cathode over dorsolateral prefrontal cortex). In the other half, electrodes were reversed as in treatments of auditory verbal hallucinations. We hypothesised that these montages would lead to increased and decreased rates of auditory false perceptions, respectively. Moreover, we expected that auditory false perceptions would be triggered more often when participants expected certain words (top-down effect) and when these words were masked by human noise (bottom-up effect). The results revealed robust top-down and bottom-up interactions, but they were neither modulated by electrode montage nor by whether real or sham tDCS was administered. The results thus support the notion that auditory-verbal hallucinations arise from an interaction of bottom-up and top-down processes but do not support the hypertemporal/hypofrontal model. Possible explanations for the lack of tDCS effects are discussed, including the idea that the tDCS electrodes might not have stimulated the targeted areas. Supplementary Material File (transcranial direct current stimulation does not increase auditory false perceptions in healthy participants_manuscript_ejn_2025.docx) Download 477.39 KB Information & Authors Information Version history V1 Version 1 26 March 2025 Peer review timeline Published European Journal of Neuroscience Version of Record 25 Dec 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords bottom-up/top-down processing hypertemporal/hypofrontal model neurostimulation signal detection task Authors Affiliations Tine Tronrud 0009-0004-5976-3413 [email protected] University of Bergen Institute of Biological and Medical Psychology View all articles by this author Isabella Kusztrits 0000-0003-3678-2860 University of Bergen Institute of Biological and Medical Psychology View all articles by this author Julien Laloyaux Psyliège View all articles by this author Marco Hirnstein University of Bergen Institute of Biological and Medical Psychology View all articles by this author Metrics & Citations Metrics Article Usage 260 views 112 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Tine Tronrud, Isabella Kusztrits, Julien Laloyaux, et al. Transcranial Direct Current Stimulation Does Not Increase Auditory False Perceptions in Healthy Participants. Authorea . 26 March 2025. DOI: https://doi.org/10.22541/au.174301760.03306436/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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