The acute effect of progestational compounds on intact rabbit myometrium

B M SCHOFIELD, Brenda M. Schofield
The Journal of physiology · 1961 · vol. 157(1) , pp. 117–123 · doi:10.1113/jphysiol.1961.sp006709 · PMID:13748429 · PMC1359920 · W2146611901
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This research investigated the acute effects of progestational compounds on the contractility of intact rabbit myometrium, building upon foundational studies regarding hormonal control and temperature-dependent muscle behavior.

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This study investigated the acute physiological effects of various progestational compounds on isolated, intact rabbit myometrium. The researchers measured changes in isometric tension and isotonic shortening to determine how these hormones influence uterine muscle contractility under controlled conditions. Results indicated that specific progestins significantly altered myometrial behavior, demonstrating a direct pharmacological impact on smooth muscle tone. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Full text PDFSelected References These references are in PubMed. This may not be the complete list of references from this article. - CSAPO A. Dependence of isometric tension and isotonic shortening of uterine muscle on temperature and on strength of stimulation. Am J Physiol. 1954 Jun;177(3):348–354. doi: 10.1152/ajplegacy.1954.177.3.348. [DOI] [PubMed] [Google Scholar] - CSAPO A. Progesterone block. Am J Anat. 1956 Mar;98(2):273–291. doi: 10.1002/aja.1000980206. [DOI] [PubMed] [Google Scholar] - SCHOFIELD B. M. Hormonal control of pregnancy by the ovary and placenta in the rabbit. J Physiol. 1960 Jun;151:578–590. doi: 10.1113/jphysiol.1960.sp006461. [DOI] [PMC free article] [PubMed] [Google Scholar] - SCHOFIELD B. M. The hormonal control of myometrial function during pregnancy. J Physiol. 1957 Aug 29;138(1):1–10. doi: 10.1113/jphysiol.1957.sp005833. [DOI] [PMC free article] [PubMed] [Google Scholar] - SCHOFIELD B. M. The influence of the ovarian hormones on myometrial behavior in the intact rabbit. J Physiol. 1955 Aug 29;129(2):289–304. doi: 10.1113/jphysiol.1955.sp005354. [DOI] [PMC free article] [PubMed] [Google Scholar]

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MeSH descriptors

Myometrium Progesterone Progestins Uterus Animals Female Humans Progesterone Rabbits Uterus

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