Клініко-патогенетичні паралелі перебігу різних форм ендометріоїдної хвороби

A comparative analysis of the clinical manifestations of adenomyosis and external endometriosis showed the dependence of the intensity lesion on the duration of disease, presence of concomitant gynecological pathology, chronic virus infection and burdened genetic history. The role of polymorphisms of genes VEGF, GSTM1, ІL-8, IL-6 and TNF-α in the determination of risk external genital endometriosis (RR 2.31, CI 95% 1,1-3,6, p < 0.05). It was shown that the cytokine balance in women with adenomyosis and external endometriosis characterized by changes in the form of overproduction of proinflammatory cytokines TNF-α, IL-6, which correlates with the severity of clinical symptoms (r = 0,74, p < 0,01). In a clinical study demonstrated the effectiveness of the use of drugs with severe procytokine activity in treatment of endometriosis.