Genetic Profiling and Performance Optimization in Elite Combat Sport Athletes: Insights from Total Genetic Score Analysis

The interplay between genetics and athletic performance has garnered significant at-tention, emphasizing the role of Performance-Enhancing Polymorphisms (PEPs) in determining traits critical for athletic success. This study investigates the genetic pre-dispositions related to PPARα, ACE, and CKM gene variants and their influence on elite Point-Fighting (PF) athletes. Twenty-four elite PF athletes underwent genetic analysis using saliva samples collected for DNA extraction. Genotyping revealed the prevalen-ceof key genetic markers, including the D allele (58.33%) and ID genotype for the ACE variant, the G allele (77.08%) and GG genotype (54.17%) for PPARα, and the A allele (77.08%) with an AA genotype (62.50%) for CKM. The Total Genetic Score (TGS) analysis highlighted a mixed-oriented predisposition among athletes, contrasting with their training practices, which are predominantly focused on strength development. These findings suggest the importance of a more balanced training approach, incorporating both aerobic and power components. Preliminary results indicate that applying TGS could enhance early talent identification and support the development of personalized training programs, ultimately improving individual performance in disciplines like PF.