Management of atypical polypoid adenomyomas. A case series

Grigoris Grimbizis, Themistoklis Mikos, Dimosthenis Miliaras, George Kioussis, Theodoros D. Theodoridis, Dimitrios Tsolakidis, Basil C. Tarlatzis
In: European Journal of Obstetrics & Gynecology and Reproductive Biology · 2017 · vol. 215 , pp. 1–5 · doi:10.1016/j.ejogrb.2017.05.017 · PMID:28578202 · W2618636492
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This case series describes the management and outcomes for patients diagnosed with atypical polypoid adenomyomas.

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Abstract

ObjectiveAtypical polypoid adenomyomas (APAs) are endometrial, non-malignant, focal, and non-invasive lesions that are intriguing for their histological resemblence to invasive endometrioid adenocarcinoma or malignant mixed Müllerian tumor. The aim of this study was to present our clinical experience, regarding the reproductive outcome, the recurrence rate, and the association with hyperplasia and cancer, in a small series of patients with APA.Study designRetrospective case series of patients treated for APA in a single private hospital setting from 1998 to 2016. All patients underwent diagnostic hysteroscopy and hysteroscopic removal of the lesion. Follow-up was performed annually with endovaginal ultrasonography and hysteroscopy when necessary.ResultsNine patients (mean age: 37.9 years-old ±8.3years) were treated because of menorrhagia, infertility, and incidental asymptomatic endometrial lesions with operative hysteroscopy. Mean follow-up was 10.0 years (±5.8years). Three patients intended for pregnancy and 2 of them had achieved a full term delivery. There were 2 recurrences (22.2%), two cases of atypical endometrial hyperplasia (22.2%), and 2 patients with endometrioid adenocarcinoma (22.2%), all within the first 5 years.ConclusionsIt appears that APAs exhibit a significant recurrence rate and they may be related both to atypical endometrial hyperplasia and endometrial adenocarcinoma; therefore, clinicians should be aware of these lesions in order to individualize treatment according to the patent's age and fertility history.

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