Hemodynamic Impact of Stenting on Carotid Bifurcation: A Potential Role in the Stented Segment and External Carotid Artery

Hemodynamic Impact of Stenting on Carotid Bifurcation: A Potential Role in the Stented Segment and External Carotid Artery | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Hemodynamic Impact of Stenting on Carotid Bifurcation: A Potential Role in the Stented Segment and External Carotid Artery Zhenmin Fan, Xiao Liu, Yingying Zhang, Nan Zhang, Xia Ye, Xiaoyan Deng This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-636853/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 25 Nov, 2021 Read the published version in Computational and Mathematical Methods in Medicine → Version 1 posted You are reading this latest preprint version Abstract Carotid stenting near the bifurcation carina is associated with adverse events, especially in-stent restenosis, in-stent thrombosis, and side branch occlusion in clinical data. This study aims to determine the potential biomechanical mechanisms for these adverse events after carotid stenting. The patient-specific carotid models were constructed with different stenting scenarios to study the flow distribution and hemodynamic parameters, such as wall shear stress (WSS), flow velocity, relative residence time (RRT), and oscillating shear index (OSI) in the carotid bifurcation. The results suggested that existing stent obviously reduced blood flow to external carotid artery (ECA) but enhanced local flow disturbance both in ECA and stented internal carotid artery (ICA), and the inner-posterior wall of stented ICA and the outer-posterior wall of ECA might endure a relatively low level of WSS and remarkably elevated OSI and RRT. In addition, the implanted stent leads to more ECA adverse flow than stented ICA. While disturbed flow in the vicinity of strut increased as stent length increased, blood flow and areas of local flow disturbance in ECA slightly decreased as stent length increased. In conclusion, the results revealed that ECA might be in relatively high levels of abnormal local hemodynamics after stenting, followed by stented ICA, leading to potential adverse events after interventions. Biomedical Engineering Carotid Bifurcation Stent Hemodynamics Restenosis Occlusion Full Text Cite Share Download PDF Status: Published Journal Publication published 25 Nov, 2021 Read the published version in Computational and Mathematical Methods in Medicine → Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-636853","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research","associatedPublications":[],"authors":[{"id":36922290,"identity":"c900bf72-ac39-4a0e-8b6a-1107480685b5","order_by":0,"name":"Zhenmin Fan","email":"","orcid":"","institution":"Jiangsu University of Technology","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Zhenmin","middleName":"","lastName":"Fan","suffix":""},{"id":36922291,"identity":"2336fb15-a1a5-4835-8dc2-f9e538069f1b","order_by":1,"name":"Xiao Liu","email":"","orcid":"","institution":"Beihang 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