Evaluation of Routine Liver Biomarkers among Type 2 Diabetic Patients with or without Chronic Kidney Disease Attending Jimma Medical Center, Jimma southwest, Ethiopia, 2025

Evaluation of Routine Liver Biomarkers among Type 2 Diabetic Patients with or without Chronic Kidney Disease Attending Jimma Medical Center, Jimma southwest, Ethiopia, 2025 | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Evaluation of Routine Liver Biomarkers among Type 2 Diabetic Patients with or without Chronic Kidney Disease Attending Jimma Medical Center, Jimma southwest, Ethiopia, 2025 Mr. Negewo kebede, Dr. zerihun Assefa, Mr. Bati Leta, Mr.Behonegn Birhan, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-9409289/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 4 You are reading this latest preprint version Abstract Background: Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia resulting from defective insulin action, secretion or both. Liver disorders are known to be a risk factor for diabetes, and diabetic patients are prone to both liver and kidney disorders. However, the association between these diseases has not yet been thoroughly studied in Ethiopia. Materials and Methods: An institution based comparative cross-sectional study was conducted among 142 individuals at Jimma Medical Center. The data were collected using consecutive sampling techniques. The data were entered into EpiData v: 4.6 and was exported to statical package for social science (SPSS) v: 26 for analysis and statistically tested at a confidence level of 95%. The mean difference was tested independently and the correlation between the explanatory and outcome variables was examined using Pearson’s correlation analysis. Bivariate and multivariate logistic regressions were used to test the predictors of the outcome variables in the study participants. Result s: In total 142 patients diagnosed with type 2 diabetes mellitus were recruited for this study. Mean values of alkaline phosphatase was higher and statically significant (115.27±22.41 vs. 97.42±29.57 P<0.001). However, mean value of, Total bilirubin (0.86 ± 0.47 vs. 1.03 ± 0.48, P =0.028,) and direct bilirubin (0 .16 ± 0.083 vs. 0.21 ±0.09 P= 0.003), were significantly lower in diabetic kidney disease patients. Waist circumference has positive correlated with direct bilirubin level (r= 0.243 , p =0.004) and the duration of diabetic follow up was positively correlated alanine aminotransferase concentration (r=0.168 P=0.045). Conclusion: Mean of ALP was significantly higher in patients type 2 diabetes with chronic kidney disease than in those without chronic kidney disease. The mean value of direct and total bilirubin value were, lower in type two diabetic patients with chronic kidney disease. Type two DM Chronic kidney diseases liver Biomarkers Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Revision requested 20 Apr, 2026 Editor assigned by journal 20 Apr, 2026 Submission checks completed at journal 18 Apr, 2026 First submitted to journal 18 Apr, 2026 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-9409289","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":625334526,"identity":"db02371d-3c35-441b-86f1-52cb28ee2f58","order_by":0,"name":"Mr. Negewo kebede","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA7UlEQVRIiWNgGAWjYHACZgbGBiDibz74AMjj4SNei8SxZAOQFjbitTDkmEmAuAS1mPOvMTb4uMNGtp/hWFrl1xw7GTYG5oePbuDRYjnjjXHizDNpxjObm4/dlt2WDHQYm7FxDh4tBjfObj7M23Y4ccOBY2m3JbcxA7XwsEkT1PK37X/i/gM5ZsWS2+qJ0HK+d3MyY9uBxA1A7zN+3HaYGFv4Pxv2nkk2nnHjWLI047bjPGzMhPxy/liyxM8ddrL9/c0HP/7cVm3Pz9788DE+LQwSCQg2Mw+YxKccBPgPINiMPwipHgWjYBSMghEJAC52UQj3Kr6+AAAAAElFTkSuQmCC","orcid":"","institution":"Madda Walabu University","correspondingAuthor":true,"prefix":"Mr.","firstName":"Negewo","middleName":"","lastName":"kebede","suffix":""},{"id":625334527,"identity":"0928c990-2925-434e-99b3-e3cc7aa662c7","order_by":1,"name":"Dr. zerihun Assefa","email":"","orcid":"","institution":"Jimma University","correspondingAuthor":false,"prefix":"Dr.","firstName":"zerihun","middleName":"","lastName":"Assefa","suffix":""},{"id":625334528,"identity":"1e9ea8e8-c141-485c-aaa9-9729391a41af","order_by":2,"name":"Mr. Bati Leta","email":"","orcid":"","institution":"Jimma University","correspondingAuthor":false,"prefix":"Mr.","firstName":"Bati","middleName":"","lastName":"Leta","suffix":""},{"id":625334529,"identity":"127e5d8a-4b67-4076-9ad9-9a60b8eae4c5","order_by":3,"name":"Mr.Behonegn Birhan","email":"","orcid":"","institution":"Jimma University","correspondingAuthor":false,"prefix":"Mr.","firstName":"Behonegn","middleName":"","lastName":"Birhan","suffix":""},{"id":625334530,"identity":"9cd4b9d6-5717-4e84-b43a-b0ed73243105","order_by":4,"name":"Mr. Abebe Dukessa","email":"","orcid":"","institution":"Jimma University","correspondingAuthor":false,"prefix":"Mr.","firstName":"Abebe","middleName":"","lastName":"Dukessa","suffix":""}],"badges":[],"createdAt":"2026-04-14 01:53:10","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-9409289/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-9409289/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":107486601,"identity":"4401e526-3ecb-4197-a808-68d971695f42","added_by":"auto","created_at":"2026-04-22 02:38:27","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":308857,"visible":true,"origin":"","legend":"","description":"","filename":"Publishableresearch.pdf","url":"https://assets-eu.researchsquare.com/files/rs-9409289/v1_covered_1d3ad258-f52a-4fd6-8bd9-84e8c99791cf.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Evaluation of Routine Liver Biomarkers among Type 2 Diabetic Patients with or without Chronic Kidney Disease Attending Jimma Medical Center, Jimma southwest, Ethiopia, 2025","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-endocrine-disorders","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bend","sideBox":"Learn more about [BMC Endocrine Disorders](http://bmcendocrdisord.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bend/default.aspx","title":"BMC Endocrine Disorders","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Type two DM, Chronic kidney diseases, liver Biomarkers ","lastPublishedDoi":"10.21203/rs.3.rs-9409289/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-9409289/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground: \u003c/strong\u003eDiabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia resulting from defective insulin action, secretion or both. Liver disorders are known to be a risk factor for diabetes, and diabetic patients are prone to both liver and kidney disorders. However, the association between these diseases has not yet been thoroughly studied in Ethiopia.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMaterials and Methods: \u003c/strong\u003eAn institution based comparative cross-sectional study was conducted among 142 individuals at Jimma Medical Center. The data were collected using consecutive sampling techniques. The data were entered into EpiData v: 4.6 and was exported to statical package for social science (SPSS) v: 26 for analysis and statistically tested at a confidence level of 95%. The mean difference was tested independently and the correlation between the explanatory and outcome variables was examined using Pearson’s correlation analysis. Bivariate and multivariate logistic regressions were used to test the predictors of the outcome variables in the study participants.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResult\u003c/strong\u003es: In total 142 patients diagnosed with type 2 diabetes mellitus were recruited for this study. Mean values of alkaline phosphatase was higher and statically significant (115.27±22.41 vs. 97.42±29.57 P\u0026lt;0.001). However, mean value of, Total bilirubin (0.86 ± 0.47 vs. 1.03 ± 0.48, P =0.028,) and direct bilirubin (0 .16 ± 0.083 vs. 0.21 ±0.09 P= 0.003), were significantly lower in diabetic kidney disease patients. Waist circumference has positive correlated with direct bilirubin level (r= 0.243\u003csup\u003e,\u003c/sup\u003e p =0.004) and the duration of diabetic follow up was\u0026nbsp;\u0026nbsp; positively correlated alanine aminotransferase concentration (r=0.168 P=0.045).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion:\u003c/strong\u003e Mean of ALP was significantly higher in patients type 2 diabetes with chronic kidney disease than in those without chronic kidney disease. The mean value of direct and total bilirubin value were, lower in type two diabetic patients with chronic kidney disease.\u003c/p\u003e","manuscriptTitle":"Evaluation of Routine Liver Biomarkers among Type 2 Diabetic Patients with or without Chronic Kidney Disease Attending Jimma Medical Center, Jimma southwest, Ethiopia, 2025","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-04-20 18:27:42","doi":"10.21203/rs.3.rs-9409289/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2026-04-20T08:26:56+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2026-04-20T08:13:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2026-04-18T07:35:47+00:00","index":"","fulltext":""},{"type":"submitted","content":"BMC Endocrine Disorders","date":"2026-04-18T07:30:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-endocrine-disorders","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bend","sideBox":"Learn more about [BMC Endocrine Disorders](http://bmcendocrdisord.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bend/default.aspx","title":"BMC Endocrine Disorders","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"93493336-10fc-4922-bdab-75703c73c041","owner":[],"postedDate":"April 20th, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2026-04-22T09:38:14+00:00","versionOfRecord":[],"versionCreatedAt":"2026-04-20 18:27:42","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-9409289","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-9409289","identity":"rs-9409289","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}