Хронічний ендометрит у жінок фертильного віку з непліддям та оперативним втручанням на матці

Chronic endometritis (CE) is known to have a negative impact on decidualization, and therefore is the cause of implantation failure, miscarriage and placentation disorders with the formation of both placental insufficiency and pathological placental invasion. Aim - to determine the frequency of CE in women of childbearing age without a history of cesarean section (CS), with infertility requiring the use of assisted reproductive technologies (IVF) or uterine surgery, who are planning pregnancy in the short term. Materials and methods. The study included 309 women of childbearing age, who were divided into 2 groups: the first - 152 women with IVF and without a history of CS; the second - 157 women of childbearing age without a history of CS, who underwent elective uterine surgery. The control group was 54 women without ART and uterine surgery in history, who applied for a scheduled examination. The presence of HE was established when 5 or more plasma cells were found in the endometrial stroma, determining the specific marker of plasma cells - CD138 by immunohistochemical method. Endometrial tissue samples were taken by Pipelle biopsy using a device (Pipelle de Cornier, CCD). Results. According to the results of the study, HE was detected in 79 (52.0%) women of the first, 73 (46.5%) of the second and in 2 (3.7%) of the control group. Conclusions. The results of the study showed that in the groups of women with IVF and gynecological surgical interventions on the uterus, a high frequency of HE was observed (52% and 46.5%, respectively), which suggests that HE may be one of the factors contributing to the development of placental disorders. However, further studies are necessary to confirm this hypothesis. The study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the local ethics committee of the participating institution. Informed consent of the patients was obtained for the study. The authors declare that there is no conflict of interest.