Cribriform polypoid adenomatous (atypical) hyperplasia of the endocervical glands of the uterus under hormonal contraception

L. Moltz, K Becker, Kenneth L. Becker
European Journal of Obstetrics & Gynecology and Reproductive Biology · 1977 · vol. 7(5) , pp. 331–336 · doi:10.1016/0028-2243(77)90018-1 · PMID:264059 · W1991308752
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This study examined cribriform adenomatous hyperplasia of the endocervical glands in women using hormonal contraception, finding significantly higher lesion prevalence in hormone-treated groups compared to controls.

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Abstract

The occurrence of cribriform adenomatous hyperplasia of the endocervical glands of the uterus was examined in 92 women, in whom punch biopsies of the ecto-endocervical line were taken during the second half of their cycle. Of these, 79 women had taken combined estrogen-progestogen preparations, 9 women had taken progestogens alone, while 14 patients formed a control group. There was a significant difference only between the control group without hormones and the groups treated with hormones. The groups of patients under the various regimens of hormonal treatment displayed a varying percentage of cribriform adenomatous hyperplasia. There was a clear tendency for such lesions to be observed more frequently under the combined type of contraception than under the sequential type. These differences were not, however, significant. A correlation with specific exogenous groups of steroids could not be established.

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MeSH descriptors

Cervix Uteri Contraceptives, Oral, Hormonal Precancerous Conditions Uterine Cervical Neoplasms Adolescent Adult Cervix Uteri Contraceptives, Oral, Hormonal Female Humans Hyperplasia Middle Aged Precancerous Conditions Precancerous Conditions Uterine Cervical Neoplasms Uterine Cervical Neoplasms

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