Bladder Endometriosis: A Great Masquerader

Parveen Rana, Sunaina Hooda, Ruchi Agarwal, Parul Parul, Monika Gathwal, Vishal Rohilla, Swaran Kaur Saluja
In: Annals of Pathology and Laboratory Medicine · 2025 · vol. 12(1) , pp. C1–6 · doi:10.21276/apalm.3456 · W4409688219
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper presents two cases of bladder endometriosis, highlighting the diagnostic utility of imaging, histopathology, and immunohistochemistry in differentiating it from other conditions.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This paper presents two clinical cases of bladder endometriosis in women with urinary symptoms that began around the menstrual cycle, including painful urination, frequent urination, hematuria, and recurrent urinary tract infection history. In both cases, imaging showed bladder lesions, and diagnosis was confirmed by histopathology demonstrating endometrial glands and hemosiderin-laden macrophages, with immunohistochemistry showing estrogen and progesterone receptor positivity (and CD10-positive stromal cells in one case). The authors note that a combined approach using imaging, histopathology, and IHC helps differentiate bladder endometriosis from malignancies or other gynecologic conditions, reducing misdiagnosis risk, though the evidence is limited to case reports. This paper is centrally about endometriosis — it focuses specifically on bladder endometriosis presenting as a diagnostic “masquerader” with ER/PR-positive tissue confirmed by immunohistochemistry.

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Abstract

Endometriosis is a chronic condition presenting with the presence of endometrium outside the uterus. Case 1: A 29-year-old woman presented with abdominal pain and painful urination for 15 days, beginning after her menstrual cycle. She had a history of frequent urination, recurrent urinary tract infections, hematuria, and two uneventful cesarean sections. Ultrasound revealed a lobulated soft tissue lesion in the posterior bladder wall. Microscopy revealed endometrial glands and hemosiderin-laden macrophages. Immunohistochemistry (IHC) confirmed bladder endometriosis with positive estrogen and progesterone receptors (ER/PR) and CD10-positive stromal cells. Case 2: A 33-year-old woman with menorrhagia, dysmenorrhea, and burning urination underwent surgery for a fibroid and ovarian cyst. During surgery, a 6.5 cm firm mass adhered to the bladder and uterus was found. Histopathology confirmed bladder endometriosis with ER-positive glands. The diagnosis of bladder endometriosis is aided by imaging techniques along with histopathology and IHC. This comprehensive approach helps differentiate bladder endometriosis from malignancies or other gynecological conditions, thus reducing the risk of misdiagnosis. Early and precise diagnosis facilitates targeted treatment, improving patient outcomes and preventing unnecessary interventions.

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Condition tags

endometriosisbladder_endometriosisdysmenorrhea

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (11)

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last seen: 2026-06-10T17:14:06.276822+00:00
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