Bladder Endometriosis: A Great Masquerader

In: Annals of Pathology and Laboratory Medicine · 2025 · vol. 12(1) , pp. C1–6 · doi:10.21276/apalm.3456 · W4409688219
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This paper presents two cases of bladder endometriosis, highlighting the diagnostic utility of imaging, histopathology, and immunohistochemistry in differentiating it from other conditions.

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This paper presents two clinical cases of bladder endometriosis in women with urinary symptoms that began around the menstrual cycle, including painful urination, frequent urination, hematuria, and recurrent urinary tract infection history. In both cases, imaging showed bladder lesions, and diagnosis was confirmed by histopathology demonstrating endometrial glands and hemosiderin-laden macrophages, with immunohistochemistry showing estrogen and progesterone receptor positivity (and CD10-positive stromal cells in one case). The authors note that a combined approach using imaging, histopathology, and IHC helps differentiate bladder endometriosis from malignancies or other gynecologic conditions, reducing misdiagnosis risk, though the evidence is limited to case reports. This paper is centrally about endometriosis — it focuses specifically on bladder endometriosis presenting as a diagnostic “masquerader” with ER/PR-positive tissue confirmed by immunohistochemistry.

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Abstract

Endometriosis is a chronic condition presenting with the presence of endometrium outside the uterus. Case 1: A 29-year-old woman presented with abdominal pain and painful urination for 15 days, beginning after her menstrual cycle. She had a history of frequent urination, recurrent urinary tract infections, hematuria, and two uneventful cesarean sections. Ultrasound revealed a lobulated soft tissue lesion in the posterior bladder wall. Microscopy revealed endometrial glands and hemosiderin-laden macrophages. Immunohistochemistry (IHC) confirmed bladder endometriosis with positive estrogen and progesterone receptors (ER/PR) and CD10-positive stromal cells. Case 2: A 33-year-old woman with menorrhagia, dysmenorrhea, and burning urination underwent surgery for a fibroid and ovarian cyst. During surgery, a 6.5 cm firm mass adhered to the bladder and uterus was found. Histopathology confirmed bladder endometriosis with ER-positive glands. The diagnosis of bladder endometriosis is aided by imaging techniques along with histopathology and IHC. This comprehensive approach helps differentiate bladder endometriosis from malignancies or other gynecological conditions, thus reducing the risk of misdiagnosis. Early and precise diagnosis facilitates targeted treatment, improving patient outcomes and preventing unnecessary interventions.
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Bladder Endometriosis: A Great Masquerader DOI: https://doi.org/10.21276/apalm.3456Keywords: Bladder, endometriosis, estrogen receptors, progesterone receptorsAbstract Endometriosis is a chronic condition presenting with the presence of endometrium outside the uterus. Case 1: A 29-year-old woman presented with abdominal pain and painful urination for 15 days, beginning after her menstrual cycle. She had a history of frequent urination, recurrent urinary tract infections, hematuria, and two uneventful cesarean sections. Ultrasound revealed a lobulated soft tissue lesion in the posterior bladder wall. Microscopy revealed endometrial glands and hemosiderin-laden macrophages. Immunohistochemistry (IHC) confirmed bladder endometriosis with positive estrogen and progesterone receptors (ER/PR) and CD10-positive stromal cells. Case 2: A 33-year-old woman with menorrhagia, dysmenorrhea, and burning urination underwent surgery for a fibroid and ovarian cyst. During surgery, a 6.5 cm firm mass adhered to the bladder and uterus was found. Histopathology confirmed bladder endometriosis with ER-positive glands. The diagnosis of bladder endometriosis is aided by imaging techniques along with histopathology and IHC. This comprehensive approach helps differentiate bladder endometriosis from malignancies or other gynecological conditions, thus reducing the risk of misdiagnosis. Early and precise diagnosis facilitates targeted treatment, improving patient outcomes and preventing unnecessary interventions. References 1. Parasar P, Ozcan P, Terry KL. Endometriosis: epidemiology, diagnosis and clinical management. Curr Obstet Gynecol Rep. 2017;6(1):34–41. 2. Seracchioli R, Mabrouk M, Montanari G, Manuzzi L, Concetti S, Venturoli S. Conservative laparoscopic management of urinary tract endometriosis (UTE): surgical outcome and long-term follow-up. Fertil Steril. 2010;94(3):856–61. 3. Chapron C, Chopin N, Borghese B, Foulot H, Dousset B, Vacher-Lavenu MC, et al. Deeply infiltrating endometriosis: pathogenetic implications of the anatomical distribution. Hum Reprod. 2006;21(7):1839–45. 4. Aliramaji A, Darzi AA, Shafi H, Ramezani MS. Bladder endometriosis: a case report. World Appl Sci J. 2011;15(12):1758–60. 5. Nezhat C, Nezhat F, Nezhat CH, Nasserbakht F, Rosati M, Seidman DS. Urinary tract endometriosis treated by laparoscopy. Fertil Steril. 1996;66(6):920–4. 6. Guerriero S, Condous G, van den Bosch T, Valentin L, Leone FP, Van Schoubroeck D, Exacoustos C, et al. Systematic approach to sonographic evaluation of the pelvis in women with suspected endometriosis, including terms, definitions and measurements: a consensus opinion from the International Deep Endometriosis Analysis (IDEA) group. Ultrasound Obstet Gynecol. 2016;48(3):318–32. 7. Nisenblat V, Bossuyt PM, Shaikh R, Farquhar C, Jordan V, Scheffers CS, Mol BW, et al. Blood biomarkers for the non-invasive diagnosis of endometriosis. Cochrane Database Syst Rev. 2016;2016(5):CD012179. 8. Fuentes Pastor J, Ballestero Diego R, Correas Gómez MÁ, Torres Díez E, Fernández Flórez A, Ballesteros Olmos G, et al. Bladder endometriosis and endocervicosis: presentation of 2 cases with endoscopic management and review of literature. Case Rep Urol. 2014;2014:296908. 9. Wellbery C. Diagnosis and treatment of endometriosis. Am Fam Physician. 1999 Oct 15;60(6):1753–62, 1767–8. 10. Trigui M, Ouanes Y, Chaker K, Zehani A, Chelly I, Nouira Y. Bladder endometriosis: a serious disease. Urol Case Rep. 2023;48:102400. 11. Bloom R, LaRusso S. Endometriosis with bladder involvement. J Diagn Med Sonogr. 2010;26(5):260–2. 12. Töz E, Ince O, Apaydın N, Gürbüz T, Dayanıklı N, Ayaz D. A case of bladder endometriosis that became symptomatic during the third trimester. Case Rep Womens Health. 2015;6:1–3. 13. Nishikawa A, Kondoh E, Hamanishi J, Yamaguchi K, Ueda A, Sato Y, et al. Ileal perforation and massive intestinal haemorrhage from endometriosis in pregnancy: case report and literature review. Eur J Obstet Gynecol Reprod Biol. 2013;170(1):20–4. Downloads Published Issue Section License Copyright (c) 2025 Parveen Rana, Sunaina Hooda, Ruchi Agarwal, Parul, Monika Gathwal, Vishal Rohilla, Swaran Kaur Saluja This work is licensed under a Creative Commons Attribution 4.0 International License. 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endometriosisbladder_endometriosisdysmenorrhea

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