The T helper (Th) T Cytotoxic (Tc) Ratio in Hemophilia Disease

Background: and Objectives:In this study, we investigated the T helper (Th) to T cytotoxic (Tc) ratio in children suffered from hemophilia disease. 80 diagnostic subjects referred to Ali Asghar hospital of Zahedan city, Zahedan-Iran, were selected and the ratio of these cells were analyzed by analytic descriptive methods.Method of study:Two mls of EDTA anti coagulated whole blood was collected. Immunophenotyping of lymphocytes count was carried out by FACS analysis using a double CD4 and CD8 kit. The mean ± SD of absolute numbers of CD4 and CD8 lymphocytes/ml was calculated and the ratio of CD4/CD8 was evaluated by statistical method. Results: We found 100% of patients were type A hemophilia. Among of them 66 (82.5%) were male. The mean age was 15±3.51 years. 12 (15%) of them had mild disease intensity and 68 (85%) had sever disease intensity. The ratio of CD4 and CD8 was obtained between 0.45 and 1.44 with mean1.79 ±0.78 and correlation with the gender and disease intesivity was 0.095 and 0.019 respectively. Conclusions: The results showed that the ratio of T helper (Th) to T cytotoxic (Tc) has significant correlation with