Molecular Docking used as an advanced tool to determine novel compounds on emerging infectious diseases: A systematic review

Abstract Emerging infectious diseases (EIDs) are among the major problems impacted on global economics and healthful living. EIDs have long been perceive as a predominant conclusion of host-pathogen adaptation. Hence, in this analysis, influence by the appearance of major factors that impact emerging infectious diseases and explicate some extensive EIDs like HIV/AIDs, H1N1 and Coronavirus. A wealth of new trends, especially in applied science is fetching progressively for the fast molecular recognizable proof of microorganisms and the more precise checking of infectious disease movement. Atomic docking is one of the prominent computational tools, involving in construction put together medication disclosure with respect to EIDs to evaluate the limiting affinities between little particles and macromolecule that can further, used as a target of HIV/AIDs, H1N1, and coronavirus. Molecular approach of influenza neuraminidase, HIV-1 protease and Spike protein of corona virus result shows Zanamivir, Nelfinavir, Saquinavir, Erythromycin and Spiramycin are favourable interaction against the selected target proteins. These novel drug compounds approved in vivo studies with reaffirm results, it is clear that the computational methods (mainly molecular docking) are found to be an effective technique for drug discovery.