The Age of Natural Menopause and Related Factors among the Population of the Tabari Cohort.

Abstract Background: Age of menopause is affected by several factors. In this study we aimed to identify the age of natural menopause and its related factors in a large-scaled population-based cohort study in Iran. Methods: In this study, we utilized a subset of data collected in enrollment phase of Tabari cohort study (TCS). Reproductive history and other related data were collected using structural questionnaire. Blood samples were collected form all participants. We analyzed data using chi-square, independent t-test and ANOVA as well as multivariate linear regression model. Results: Among all participants of Tabari cohort, 2753 were menopause women. The mean age of natural and induced menopause was 49.2±4.7 and 43.2 ± 6.4 respectively (P = 0.001). Our finding showed that number of pregnancy, breastfeeding duration, education, residency, thyroid disease and body mass index affect age of menopause. After adjustment for confounding variables, number of pregnancy remained significantly associated with late menopause. Conclusion: Results of the present study showed that number of pregnancy was positively associated with menopausal age.