Status of sentinel lymph node biopsy in gynecological cancers.

Levenback CF

doi:10.1245/s10434-007-9516-3

Status of sentinel lymph node biopsy in gynecological cancers.

Levenback CF

Annals of surgical oncology · 2008 · doi:10.1245/s10434-007-9516-3 · PMID:17943389 · PMC2190338

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Sentinel lymph node biopsy has been extensively studied for gynecological cancers like endometrial, vulvar, and cervical cancer, but has not replaced lymphadenectomy as the standard surgical management.

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This review examines the application and limitations of sentinel lymph node biopsy across gynecological malignancies, including endometrial, vulvar, and cervical cancers. While the technique has become standard in breast cancer and melanoma to reduce morbidity like lymphedema, its adoption in gynecologic oncology remains limited by complex lymphatic drainage patterns and concerns regarding false-negative rates. The author notes that for cervical cancer, factors such as prior pelvic inflammation or trauma may alter drainage, though specific data on endometriosis is not provided. Relevance to endometriosis: listed as one potential factor affecting lymphatic drainage in cervical cancer patients, though the paper's main focus is surgical staging of gynecological cancers.

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References

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Results

of NSABP B-32, a randomized phase III clinical trial to compare sentinel node resection to conventional axillary dis- section in clinically node-negative breast cancer patients San Antonio, TX: San Antonio Breast Cancer Symposium; 2004. STATUS OF SENTINEL LYMPH NODE BIOPSY 19 Ann. Surg. Oncol. Vol. 15, No. 1, 2008 2. Singletary SE, Connolly JL. Breast cancer staging: working with the sixth edition of the AJCC Cancer Staging Manual. CA Cancer J Clin 2006; 56:37–47; quiz 50–1. 3. Balch CM, Buzaid AC, Soong SJ, et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol 2001; 19:3635–48. 4. Burke TW, Levenback C, Tornos C, et al. Intraabdominal lymphatic mapping to direct selective pelvic and paraaortic lymphadenectomy in women with high-risk endometrial can- cers: results of a pilot study. Gynecol Oncol 1996; 62:169–73. 5. Niikura H, Okamura C, Akahira J, et al. Sentinel lymph node detection in early cervical cancer with combination 99mTc phytate and patent blue. Gynecol Oncol 2004; 94:528–32. 6. Van der Zee AG, Oonk MH, de Hullu JA, et al. On the safety of implementation of the sentinel node procedure in vulvar cancer, an observational study. Int J Gynecol Cancer 2006; 16:608. 7. Coutant C, Morel O, Delpech Y, et al. Laparoscopic sentinel node procedure for cervical cancer: impact of neoadjuvant chemoradiotherapy. Ann Surg Oncol 2007; 14:2392–99. 8. Hauspy J, Beiner M, Harley I, et al. Sentinel lymph nodes in early stage cervical cancer. 2007; Gynecol Oncol 104. 9. Rob L, Strnad P, Robova H, et al. Study of lymphatic map- ping and sentinel node identiﬁcation in early stage cervical cancer. Gynecol Oncol 2005; 98:281–8. C. F. LAVENBACK ET AL.20 Ann. Surg. Oncol. Vol. 15, No. 1, 2008

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