An Elevated High-Density Lipoprotein Cholesterol Levels Is Associated with Favorable Outcomes of Patients with Small-Artery Occlusion

An Elevated High-Density Lipoprotein Cholesterol Levels Is Associated with Favorable Outcomes of Patients with Small-Artery Occlusion | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article An Elevated High-Density Lipoprotein Cholesterol Levels Is Associated with Favorable Outcomes of Patients with Small-Artery Occlusion Hao Ruixiao, Liu Peipei, Wang Yajing, Jialing Wu This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.294/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: The relationship between high-density lipoprotein (HDL) cholesterol and small-artery occlusion (SAO) is not well understood. Methods: A total of 3067 consecutive patients with SAO were recruited from Tianjin Huanhu Hospital between January 01, 2008, and December 31, 2015. HDL values at admission were classified into four groups according to quartiles (<0.92, 0.92–1.08, 1.08–1.28, and ≥1.28). Patients were followed up to 12 months after stroke. Prognoses, represented by modified Rankin scale (mRS), were estimated via HDL quartiles upon admission utilizing multivariate logistic regression analysis. Meanwhile, we conducted additional subgroup analyses to investigate associations according to age. Results: Among 3067 patients, 2284(74.5%) were classified as having favorable outcomes, 783(25.5%) had a composite of poor outcomes,recurrent stroke, myocardial infarction or vascular death within 12 months. After adjustment for possible confounders, HDL levels in the two highest quartiles (1.08–1.28 and ≥1.28) were correlated with the 12-month primary outcome of patients with SAO (1.08–1.28 , 0.587; 95% CI,0.394-0.873; P = 0.009; ≥1.28, 0.448; 95% CI, 0.291-0.688; P < 0.001). However, a direct correlation was found in patients aged 45–75 years (1.08–1.28, P = 0.033; ≥1.28, P = 0.001).Similar to the primary outcome,a direct correlation was also found in patients aged 45–75 years with a 12-month secondary outcomes(≥1.28 mmol/L, p = 0.001). Conclusions: An elevated HDL cholesterol level in patients with SAO is an independent predictor of a favorable prognosis 12 months after SAO. However, the association was only present in patients aged 45–75 years. Keywords: High-Density Lipoprotein Cholesterol, Stroke, Outcome, Small-Artery Occlusion. Internal Medicine Specialties High-Density Lipoprotein Cholesterol Stroke Outcome Small-Artery Occlusion Figures Figure 1 Background Stroke is a disease with high mortality and incidence rates worldwide; thus, it is an important health topic and is associated with an increased global economic burden [1,2]. Ischemic stroke events account for 71% of global stroke cases, and are classified into five subtypes according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) [3,4]. Small-artery occlusion (SAO), one subtype caused by the occlusion of the branches of small penetrating arteries, accounts for 25% of ischemic stroke cases [5]. Despite its association with lower mortality and disability rates, the prevalence and progression of SAO is associated with motor dysfunction, including falls, as well as progressive cognitive decline, vascular dementia, and vascular parkinsonism. Furthermore, cerebral small vessel diseases such as SAO present a risk that can impair the quality of life. [6-8]. Although the pathophysiology of SAO is not clear, it is crucial to identify risk factors and explore ways to improve the quality of life for patients and reduce stroke burden [5,9]. Several studies have identified risk factors strongly associated with SAO prognoses including irregular glucose metabolism, fibrinogen abnormalities, and lipid metabolism disorders [7,10,11,12]. In particular, studies evaluated the role of dyslipidemia factors, including elevated low density lipoprotein (LDL) cholesterol, triglycerides (TG), total cholesterol (TC), and decreased high-density lipoprotein (HDL) cholesterol. A strong correlation between LDL cholesterol level, coronary heart disease, and stroke has been demonstrated by numerous studies [11-13]. While reports have revealed that TG and TC levels are associated with lacunar infarction [14,15,16], there have been few investigations evaluating HDL cholesterol levels that can predict ischemic stroke; moreover, the outcomes are inconsistent. It is imperative to clarify this association and provide appropriate clinical guidance. The aim of this study was to investigate the association between HDL levels and SAO prognoses in patients with stroke categorized by age. Methods Study population Consecutive patients with stroke were chosen from a hospital-based registry established in Tianjin Huanhu Hospital, a specialized neurology hospital in Tianjin, China. We reviewed and extracted detailed information on patients from the registry between January 01, 2008, and December 31, 2015. Patients who had their first ischemic stroke event within 7 days of onset and whose medical history, behavioral factors, family history, neurological examination, standard 12-lead echocardiography, standardized blood tests, and imaging (magnetic resonance imaging or computed tomography) results led to a subsequent SAO diagnosis were included in our study; in addition, our inclusion criteria also required HDL values to be provided upon admission. Patients with a stroke classification of atherothrombotic, cardioembolic, and other or undetermined causes according to TOAST criteria were excluded from our analysis. Other exclusion factor included no data on lipids and lack of follow-up. Among the 17,980 patients diagnosed with ischemic stroke according to World Health Organization criteria [17], 3483 were diagnosed with SAO upon admission; thus, the 14,497 patients with non-SAO strokes were excluded from our study. After excluding patients that did not have HDL data on blood lipids collected upon admission,missing follow-up reports or other reasons, 3067 patients with SAO remained that met all the inclusion criteria and were analyzed in the present study (Figure 1). Patients were classified into three subgroups according to age (<45 years, n = 140; ≥45 and <75 years, n = 2054; ≥75 years, n = 312). Patients were evaluated for SAO by two experienced neurologists. SAO cases categorized as lacunar infarcts using other classification systems [18] were diagnosed based on the following criteria: The patient exhibited one of the traditional clinical lacunar syndromes without evidence of cerebral cortical dysfunction. Patients also had a relevant brain stem or subcortical hemispheric lesion < 1.5 cm in diameter detected via computed tomography or magnetic resonance imaging. Additionally, no potential cardiac sources for embolism were present and stenosis was less than 50% in an ipsilateral artery. A history of diabetes mellitus or hypertension further supported the clinical diagnosis. All patients included in present study were diagnosed with Small-artery occlusion,those with a poor prognosis for survival (loss of consciousness or severe comorbidities), those with preexisting disabilities of the extremities were excluded from this study. Demographic and clinical assessment Baseline information and stroke risk factors were obtained from a record of clinical history within 24 hours of admission; information included age, sex, medical history, and detailed demographic data. Biochemical variables in the blood were measured following a fasting period of at least eight hours on the first day after admission and were analyzed in a certified central laboratory. HDL values were classified into four quartiles (<0.92, 0.92–1.08, 1.08–1.28，and ≥1.28 mmol/L), since quartile classification is the most common statistical layering method. Hypertension was documented for patients with a systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥ 90 mmHg on the seventh day after stroke onset, systolic and diastolic blood pressures of 140/90 mmHg, and for patients taking antihypertensive medications [15]. Diabetes mellitus was identified in patients with fasting blood glucose levels ≥ 7.0 mmol/L, non-fasting glucose levels ≥ 11.1 mmol/L, a previous diagnosis of diabetes, and/or the use of hypoglycemic agents with a glycated hemoglobin (HbA1c) level ≥ 6.5% at the time of admission [19,20]. Dyslipidemia was characterized in patients being treated with cholesterol-reducing agents as well as in patients with a TG level > 2.26 mmol/L (200 mg/dL) or a TC level > 6.21 mmol/L (240 mg/dL). Individuals who had smoked tobacco products every day for more than a year were defined as current smokers. Alcohol drinkers were defined as those who consumed alcohol at least once per week for more than 1 year. Body mass index (kg/m 2 ) was calculated at the time of admission, and obesity was defined as a body mass index ≥ 30 kg/m 2 [21]. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) [22]. Functional outcome and follow-up The primary outcome was prognoses of patients with SAO (favorable or poor prognoses) during a 12-month period after stroke onset.Secondary outcomes included poor prognoses, and composite of recurrent stroke,myocardial infarction (MI) or vascular death within 12 months. The 12-month follow-up was done by telephone interviews or in-person interviews; all results were recorded into our electronic stroke database immediately to ensure reliability. The modified Rankin scale (mRS) was used to evaluate functional outcomes: mRS scores of 0–2 represented favorable prognoses and mRS scores of 3–5 indicated poor prognoses. Statistical analysis In this study, continuous variables are presented as means ± standard deviations and categorical variables are reported as counts and proportions. We assessed the significance of intergroup differences using t-tests and one-way analysis of variance tests; chi-squared tests or Fisher’s exact tests were used to determine differences between groups. A multiple logistic regression analysis was used to evaluate the relationship between HDL levels and stroke prognoses with mRS scores. Statistical analyses were performed using the Statistical Package SPSS 24.0. All tests were two-sided, and p values < 0.05 were considered statistically significant. Results Baseline demographics and clinical characteristics of study participants Table 1 outlines the baseline demographics and clinical characteristics according to the HDL quartiles. The mean HDL level of all patients was 1.126 ± 0.31 mmol/L (range, 0.25–6.11 mmol/L). NIHSS scores ranged from 0 to 14. In the present study, we collected data on 3067 patients (2134 men [69.6%]; 933 women [30.4%]). Mean age was 61.94±11.08 years. Among them, 29.5% had diabetes and 64.7% had hypertension. There was a statistically significant difference among the stratifications regarding HDL levels and lipid metabolism disorders (p < 0.05). Patients with HDL levels in the highest quartile were less likely to have diabetes (n = 164, 21.2%) and to smoke (n = 267, 34.5%). Evaluation of risk factors between groups classified by outcomes Table 2 describes the comparison of risk factors between different groups classified by outcomes. Among patients, 2284 (74.5%) had an favorable outcome. As it shows the following factors to be independently associated with the 12-month primary outcomes: age, HDL levels, and NIHSS scores (p < 0.001,p = 0.006,p < 0.001,respectively).Younger patients(60.87±10.82) had more favorable outcomes than older patients(64.23±11.00).However, there were no significant associations with other risk factors (sex, hypertension, diabetes, smoking, alcohol consumption, and obesity). In addition,of 3067 patients,783(25.5%) had a composite of poor outcomes,recurrent stroke, MI or vascular death within 12 months. Similar to the primary outcome predictors,secondary outcomes were significantly correlated with age, HDL levels, and NIHSS scores(all p values < 0.05).Patiets with favorable outcomes were more likely to be the younger(60.87±10.82). Multivariate logistical regression analyses of HDL groups and outcomes Table 3 presents the results of the logistic regression analyses of HDL levels and outcome variables. As shown in the table, HDL levels in the two higher quartiles (1.08–1.28 , ≥1.28) were significantly associated with the 12-month primary outcome as compared with the reference of HDL levels in the lowest quartile (adjusted odds ratio, 1.08–1.28 , 0.587; 95% CI,0.394-0.873; P = 0.009; ≥1.28, 0.448; 95% CI, 0.291-0.688; P < 0.001). Similar to the primary outcome,with 12-month secondary outcomes, patients with HDL levels in the two higher quartiles (1.08–1.28 , ≥1.28) had more favorable outcomes(adjusted odds ratio, 1.08–1.28 , 0.788; 95% CI, 0.621-0.999; P = 0.049; ≥1.28, 0.713; 95% CI, 0.560-0.909; P = 0.006).Meanwhile, there was a statistically significant association between age and SAO primary and secondary outcome (both P values < 0.001). Table 4 further shows the association between HDL levels and outcomes according to age. We found a statistically significant direct correlation for the age range of 45–75 years with the primary outcome of stroke(1.08–1.28 mmol/L, p = 0.033; ≥1.28 mmol/L, p = 0.001, respectively).Furthermore,the similar association was found for patients with the secondary outcomes(≥1.28 mmol/L, p = 0.001). However, no association was found between outcomes and the lower HDL stratification with the age range of 45–75 years, neither the primary outcome(0.92–1.08; p = 0.064) nor the secondary outcomes(0.92–1.08; p = 0.305). Discussion The present study analyzed the clinical data of patients with SAO according to different age groups using data obtained from a hospital-based stroke registry from Tianjin, located in northern China. The higher HDL stratification levels (1.08–1.28, ≥1.28) were strongly correlated with favorable outcomes of patients with SAO; this clear positive association was observed in patients from 45 to 75 years of age. Our results indicated that elevated HDL cholesterol levels may facilitate a favorable prognosis for patients with SAO. Previous studies have demonstrated that low HDL cholesterol levels were not only associated with the risk of incident stroke, but also with cerebral small vessel disease [19,23,24,25,26]. In addition, both the Japan Public Health Center study (2017) and the Holmes (2018) study reported an inverse relationship between HDL cholesterol levels and SAO. Furthermore, the Holmes (2018) study provided evidence demonstrating that cholesterol ester transfer proteins mediated higher HDL cholesterol levels and were associated with a lower risk of SAO, genetically [19,25,26]. Our results support these study findings; however, a meta-analysis of randomized controlled trials did not show that raising HDL levels will reduce the risk of stroke, but these results could have been affected by off-target effects of the drugs [27]. Moreover, a Framingham study provided no evidence to support a causal relationship between the role of 47 HDL cholesterol single nucleotide polymorphisms and ischemic stroke [28]; however, compared with the 3067 patients in our study, this previous study only involved 301 participants with ischemic stroke. Differences between our study results and previous studies may be due to patient race, age, and analytic strategies; for instance, the percentage of women was higher in the aforementioned Framingham study, 56% [28], compared with the 30.4% of women in our study. Our analysis revealed an inconsistent association between HDL and stroke similar to previous findings concerning cardiovascular disease [29]. Some randomized controlled trials explored the clinical benefits of elevated HDL cholesterol levels for patients diagnosed with cardiovascular disease by adding niacin to statin therapy. One study showed that elevated HDL levels contributed to the regression of angiographic coronary-artery stenoses [30]; however, another study surprisingly reported no clinical benefits after increasing HDL cholesterol levels for patients with cardiovascular disease and failed to provide evidence for a causal link between extended-release niacin and ischemic stroke [29]. Nevertheless, there are no reported clinical studies analyzing the relationship between elevated HDL levels and ischemic stroke or ischemic stroke subtypes; thus, further evaluation is needed to clarify these contradictory findings. Nevertheless, our results are valid and may be used to provide clinical guidance in northern China. Additionally, our previous studies found that hemoglobin A1c levels and high-sensitivity C-reactive proteins (hs-CRPs) were associated with SAO outcomes [10,31]. Although, hyperglycemia and hs-CRPs may be related to endothelial damage and inflammatory responses, thus leading to the occlusion of deep penetrating vessels, dysglycemia may also intensify lipid disorders that can aggravate the inflammatory responses of vessels. Therefore, these risk factors are independent and interrelated, further signifying the importance of evaluating risk factors related to dyslipidemia in clinical practice. Although there is a significant relationship between HDL cholesterol and SAO, the underlying mechanism is not clear. HDL plays a key role in promoting reverse cholesterol transport from the periphery to the liver. Furthermore, mounting evidence has demonstrated that the reverse cholesterol transport process may provide protection from atherosclerosis, which can lead to lacunar infarcts through artery occlusion [26,32]; in fact, some studies found impaired carbon dioxide (CO 2 ) vasoreactivity in lacunar infarct patients. While serum HDL cholesterol affects cerebral vasculature CO 2 reactivity by increasing the permeability of the blood-brain barrier, the increased permeability may lead to glial and neuronal damage by allowing blood products to diffuse into the perivascular space[26]. Also, some evidence suggests that HDL cholesterol may activate endothelial nitric oxide synthase to promote endothelial repair, induce angiogenesis, and increase platelet reactivity, anti-inflammatory reactions, and hypercoagulability functions[19,33,34]. Furthermore, modulating HDL levels may be implicated in vascular remodeling and functional recovery [34,35,36]. Our study also found that elevated HDL cholesterol levels were associated with favorable prognoses only in patients aged from 45 to 75 years after multivariate adjustment, and this association was presented both in the primary outcome group and the secondary outcomes.Similar to our study,Aleksandra et al found that lower HDL cholesterol levels was significant in middle-aged and elderly persons[23],which may be strongly correlated with the HDL cholesterol’s above-mentioned anti-inflammatory and anti-atherogenic pathophysiology。No association was presented between HDL cholesterol levels with SAO outcomes in the oldest-old patients(≥ 75 years).That might be associate with a higher risk of comorbidity with increasing age, and multiple risk factors acting together may attenuate the impact of any one independent risk or protective factor,such as the protection of HDL cholesterol.Studies have indicated hypertension,hyperglycemia and dyslipidemia were the major risk factors of small artery occlusion in young adults.Nevertheless,the young people have less complication,higher compensatory function and adjustable life style.Controlling weight and alcohol,quit smoking,exercise and good medication compliance can regulate blood pressure,blood glucose and lipid metabolism,which contribute to favorable outcomes in the young. The clinical information that was collected for a large number of SAO cases, promptly drawn blood samples, and inclusion of adults of any age enhanced the robustness of our study. Our findings suggest the importance of maintaining HDL cholesterol values in higher stratifications using lipid-regulating drugs or proper exercise for patients with SAO. However, there were several limitations to our study. First, we collected clinical information for SAO cases from one hospital in Tianjin; thus the patient population does not represent the general population of China that may otherwise vary by region, diet, lifestyle, and other factors. Furthermore, we did not consider the use of lipid-lowering medications such as statins. The influence of statins on HDL cholesterol values during the follow-up period is unclear and may have affected the outcomes of patients with SAO. In addition, patients without HDL cholesterol data upon at admission were not included in this study, which may have presented a selection bias. Finally, other limitations were those particularly inherent to retrospective studies. Abbreviations CI, confidence interval; HbA1c, hemoglobin A1c; HDL-C, High-Density Lipoprotein Cholesterol; hs-CRP, High-Sensitivity C-Reactive Protein; LAA, large-artery atherosclerosis ; LDL-C, Low-Density Lipoprotein Cholesterol; mRS, modified Rankin scale; NIHSS ,National Institutes of Health Stroke Scale; OR, odds ratio; SAO, Small-artery occlusion; TOAST, Trial of ORG10172 in Acute Stroke Treatment; TC, Total Cholesterol; TG, Triglycerides Declarations Ethics approval and consent to participate The Ethics Committee of Tianjin Huanhu Hospital approved the study protocol. All patients consent to participate in this observational study. Written informed consent was obtained from each participant according to the demand of Local Ethics Committee of Tianjin Huanhu Hospital. A written consent could be obtained directly from the patient. In some circumstances that the patient was unable to sign because of hemiplegia, a written consent could be obtained from a family member. The ethics committee approved this procedure. Consent for publication Not applicable. Availability of data and materials The datasets analysed during the current study are available from the corresponding author on reasonable request. Competing interests All authors declare that they have no competing interests. Funding This study was generously supported by the National Natural Science Foundation of China (81671169, to J.W), Tianjin Municipal Science and Technology Commission (17JCZDJC36500, to J.W), and Grants from General Administration of Sport of China (2015B098, to J.W). The former two grants supported the design, data collection and analysis of this study, and the latter one supported the interpretation of data and in writing the manuscript. Authors’ contributions JW took part in design of the study, funding obtained, interpretation of the data and revising the manuscript. RH, PL and YW carried out the studies, participated in collecting data. RH, and PL drafted the manuscript.RH and YW performed the statistical analysis and participated in its design. All authors read and approved the final manuscript. Acknowledgements The authors acknowledge the invaluable participation of the patients. References Krishnamurthi RV, Feigin VL, Forouzanfar MH, Mensah GA,Connor M, Bennett DA,Moran AE,Sacco RL, Anderson LM,Truelsen T, O'Donnell M, Venketasubramanian N,Barker-Collo S, Lawes CM, Wang W, Shinohara Y, Witt E,Ezzati M, Naghavi M,Murray C; Global Burden of Diseases,Injuries, Risk Factors Study 2010 (GBD 2010); GBD Stroke Experts Group. 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Tables Table 1 - Baseline demographics and clinical characteristics according to HDL groups Quartile of HDL , mmol/L <0.92 ( n =733) 0.92 to < 1.08 ( n =768) 1.08 to < 1.28 ( n = 791) ≥ 1.28 ( n =775) P Age, years (median values) 61.42±11.28 62.39±11.26 61.98±10.89 61.95±10.87 0.409 Male sex, n(%)* 542(73.9) 511(66.5) 528(66.8) 553(71.4) 0.003 Risk factors Hypertension, n(%) 490(66.8) 479(62.4) 525(66.4) 489(63.1) 0.162 Diabetes, n(%)* 305(41.6) 213(27.7) 223(28.2) 164(21.2) <0.001 Smokers, n(%)* 305(41.6) 297(38.7) 302(38.2) 267(34.5) 0.040 Alcohol drinkers, n(%) 120(16.4) 116(15.1) 126(15.9) 125(16.1) 0.915 Obesity, n(%) 54(7.4) 48(6.3) 53(6.7) 37(4.8) 0.194 Laboratory findings TG, mmol/L(median values)* 2.09±1.48 1.76±1.00 1.58±0.88 1.46±0.96 <0.001 TC, mmol/L(median values)* 4.59±1.82 4.87±0.95 5.05±0.98 5.39±1.06 <0.001 HDL-C, mmol/L(median values)* 0.79 ± 0.97 0.99 ± 0.45 1.17 ± 0.56 1.53 ± 0.30 <0.001 LDL-C, mmol/L(median values)* 2.68±0.79 2.90±0.78 2.96±0.79 3.02±0.85 <0.001 NIHSS, n(%) 0.526 0-6 538(73.4) 548(71.4) 570(72.1) 577(74.5) 7-14 195(26.6) 220(28.6) 221(27.9) 198(25.5) * Indicates P< 0.05 when comparing between four groups. TC, total cholesterol; TG, triglyceride; HDL, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol;NIHSS, National Institute of Health stroke scale Table 2 - Comparison of the risk factors between different groups classified by outcomes mRS≤2 mRS≥3 P Value mRS≤2 Composite endpoints P Value ( n =2284) ( n =222) ( n =2284) ( n =783) Age, years (median values) 60.87±10.82 64.23±11.00 <0.001 60.87±10.82 65.08±11.23 <0.001 Male sex, n(%) 1596(69.9) 142(64.0) 0.068 1596 （ 69.9 ） 538 （ 68.7 ） 0.540 Hypertension, n(%) 1482(64.9) 135(60.8) 0.226 1482 （ 64.9 ） 501 （ 64.0 ） 0.649 Diabetes, n(%) 660(28.9) 74(33.3) 0.166 660 （ 28.9 ） 245 （ 31.3 ） 0.205 Smokers, n(%) 868(38.0) 78(35.1) 0.400 868 （ 38.0 ） 303 （ 38.7 ） 0.730 Alcohol drinkers, n(%) 366(16.0) 34(15.3) 0.783 366 （ 16.0 ） 121 （ 15.5 ） 0.706 Obesity, n(%) 151(6.6) 13(5.9) 0.664 151 （ 6.6 ） 41 （ 5.2 ） 0.171 HDL, n(%) 0.006 0.037 <0.92 527(23.1) 69(31.1) 527 （ 23.1 ） 206 （ 26.3 ） ≥0.92 558(24.4) 60(27.0) 558 （ 24.4 ） 210 （ 26.8 ） ≥1.08 597(26.1) 54(24.3) 597 （ 26.1 ） 194 （ 24.8 ） ≥1.28 602(26.4) 39(17.6) 602 （ 26.4 ） 173 （ 22.1 ） NIHSS, n(%) <0.001 <0.001 0-6 1795(78.6) 75(33.8) 1795 （ 78.6 ） 438 （ 55.9 ） ≥ 7 489(21.4) 147(66.2) 489 （ 21.4 ） 345 （ 44.1 ） mRS: modified Rankin scale; NIHSS: National Institute of Health stroke scale;HDL, high-density lipoprotein cholesterol; Table 3 - Multivariate logistical regression analyses of HDL groups and the outcome variables Primary outcome Secondary outcome OR ( 95% CI ) P Value OR ( 95% CI ) P Value Age 1.026(1.012-1.039) <0.001 1.034 （ 1.026-1.042 ） <0.001 HDL <0.92 index index index index ≥0.92 0.706(0.478-1.042) 0.079 0.901 （ 0.712-1.140 ） 0.386 ≥1.08 0.587(0.394-0.873) 0.009 0.788 （ 0.621-0.999 ） 0.049 ≥1.28 0.448(0.291-0.688) <0.001 0.713 （ 0.560-0.909 ） 0.006 NIHSS 0-6 index index index index ≥ 7 7.165(5.314-9.660) <0.001 2.796 （ 2.345-3.333 ） <0.001 mRS: modified Rankin scale; NIHSS: National Institute of Health stroke scale;HDL, high-density lipoprotein cholesterol; Table 4 - Multivariate logistical regression analyses of HDL groups classified by age and outcomes OR(95%CI) P Value OR(95%CI) P Value OR(95%CI) P Value < 45 ( n =140) 45 to <75 ( n =2054) ≥ 75 ( n =312) Primary outcome HDL < 0.92 index index index ≥ 0.92 0.585(0.049-6.971) 0.672 0.650(0.411-1.026) 0.064 0.977(0.434-2.202) 0.956 ≥ 1.08 2.788(0.404-19.243) 0.298 0.615(0.393-0.963) 0.033 0.380(0.145-0.998) 0.049 ≥ 1.28 0.000(0.000-) 0.998 0.452(0.278-0.734) 0.001 0.496(0.188-1.307) 0.156 NIHSS 0-6 index index index ≥ 7 4.573 （ 0.810-25.832) 0.085 8.501(6.010-12.024) <0.001 3.937(2.060-7.524) <0.001 < 45 ( n =156) 45 to <75 ( n =2462) ≥ 75 ( n =449) Secondary outcome Age 0.984 （ 0.889-1.089 ） 0.756 1.026(1.013-1.038) <0.001 1.056(1.001-1.115) 0.046 HDL < 0.92 index index index ≥ 0.92 0.742(0.189-2.911) 0.668 0.868(0.663-1.137) 0.305 1.091(0.639-1.863) 0.750 ≥ 1.08 2.664(0.803-8.844) 0.109 0.788(0.602-1.030) 0.081 0.639(0.365-1.119) 0.118 ≥ 1.28 0.691(0.156-3.065) 0.627 0.684(0.520-0.901) 0.007 0.830(0.473-1.456) 0.516 NIHSS 0-6 index index index ≥ 7 2.706(0.983-7.448) 0.054 2.995(2.451-3.659) <0.001 2.119(1.424-3.155) <0.001 mRS: modified Rankin scale; NIHSS: National Institute of Health stroke scale;HDL, high-density lipoprotein cholesterol; Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-294","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":4899,"identity":"3705725e-ebc8-414b-a1d9-2f7b638138df","order_by":1,"name":"Hao Ruixiao","email":"","orcid":"","institution":"Tianjin Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Hao","middleName":"","lastName":"Ruixiao","suffix":""},{"id":4900,"identity":"2c9a1ad6-7956-4924-8c98-1731c89b76ed","order_by":2,"name":"Liu Peipei","email":"","orcid":"","institution":"Tianjin Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Liu","middleName":"","lastName":"Peipei","suffix":""},{"id":4901,"identity":"bbcbbaa5-669c-497d-9a8d-5168255283e8","order_by":3,"name":"Wang Yajing","email":"","orcid":"","institution":"Tianjin Huanhu Hospital\t","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Wang","middleName":"","lastName":"Yajing","suffix":""},{"id":4902,"identity":"85065f5f-d0d9-49e8-a362-30de5db86e69","order_by":4,"name":"Jialing Wu","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA4klEQVRIie3RMQrCMBSA4UAgLsE6VhTP8CTQSfQqCUKnKI6Kg4Kgi7h7C6fOLRlc4l5xqTqLegGxcXNpOgrm31LeR5oEIZfrR4Ns7FOvsv4saLUU4brTqq81QnFOSKltxDJkkMoPQVaST8KIEyV2x1tyfcpukyB8vqQWApwqsT0N+5BE/fzHCGOygATpYAfcV2JzkoGfRDgnlDTsBJSYH7Uhs7KEh6yWUkOUnfT0/QE8NpcsGRyiPSXYcpb6Kgzh+TJPqdvZJJr2vMrifC0iqMYJfH/BReMmL8aZbcblcrn+vDd0ok33PM7TjQAAAABJRU5ErkJggg==","orcid":"","institution":"Tianjin Huanhu Hospital","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Jialing","middleName":"","lastName":"Wu","suffix":""}],"badges":[],"createdAt":"2019-02-04 22:39:48","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.2.294/v1","doiUrl":"https://doi.org/10.21203/rs.2.294/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":2606441,"identity":"4be044c3-c59d-4da2-af62-ce11dfb00f80","added_by":"dbe1c910-fa3f-4a3a-a5c6-af99624d3e99","created_at":"2020-09-25 20:48:57","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":48059,"visible":true,"origin":"","legend":"Flowchart for patient selection.","description":"","filename":"figure1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-294/v1/figure_1.jpg"},{"id":13465937,"identity":"7326c5bf-9d99-4a0a-ad7f-055212bbf739","added_by":"auto","created_at":"2021-09-16 20:48:51","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":684574,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-294/v1/e414ec90-033a-45e6-baa4-a106e25ecaf7.pdf"}],"financialInterests":"","formattedTitle":"An Elevated High-Density Lipoprotein Cholesterol Levels Is Associated with Favorable Outcomes of Patients with Small-Artery Occlusion","fulltext":[{"header":"Background","content":"\u003cp\u003eStroke is a disease with high mortality and incidence rates worldwide; thus, it is an important health topic and is associated with an increased global economic burden [1,2]. Ischemic stroke events account for 71% of global stroke cases, and are classified into five subtypes according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) [3,4]. Small-artery occlusion (SAO), one subtype caused by the occlusion of the branches of small penetrating arteries, accounts for 25% of ischemic stroke cases [5]. Despite its association with lower mortality and disability rates, the prevalence and progression of SAO is associated with motor dysfunction, including falls, as well as progressive cognitive decline, vascular dementia, and vascular parkinsonism. Furthermore, cerebral small vessel diseases such as SAO present a risk that can impair the quality of life. [6-8]. Although the pathophysiology of SAO is not clear, it is crucial to identify risk factors and explore ways to improve the quality of life for patients and reduce stroke burden [5,9].\u003c/p\u003e\n\u003cp\u003eSeveral studies have identified risk factors strongly associated with SAO prognoses including irregular glucose metabolism, fibrinogen abnormalities, and lipid metabolism disorders [7,10,11,12]. In particular, studies evaluated the role of dyslipidemia factors, including elevated low density lipoprotein (LDL) cholesterol, triglycerides (TG), total cholesterol (TC), and decreased high-density lipoprotein (HDL) cholesterol. A strong correlation between LDL cholesterol level, coronary heart disease, and stroke has been demonstrated by numerous studies [11-13]. While reports have revealed that TG and TC levels are associated with lacunar infarction [14,15,16], there have been few investigations evaluating HDL cholesterol levels that can predict ischemic stroke; moreover, the outcomes are inconsistent. It is imperative to clarify this association and provide appropriate clinical guidance. The aim of this study was to investigate the association between HDL levels and SAO prognoses in patients with stroke categorized by age.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003eStudy population\u003c/p\u003e\n\u003cp\u003eConsecutive patients with stroke were chosen from a hospital-based registry established in Tianjin Huanhu Hospital, a specialized neurology hospital in Tianjin, China. We reviewed and extracted detailed information on patients from the registry between January 01, 2008, and December 31, 2015. Patients who had their first ischemic stroke event within 7 days of onset and whose medical history, behavioral factors, family history, neurological examination, standard 12-lead echocardiography, standardized blood tests, and imaging (magnetic resonance imaging or computed tomography) results led to a subsequent SAO diagnosis were included in our study; in addition, our inclusion criteria also required HDL values to be provided upon admission. Patients with a stroke classification of atherothrombotic, cardioembolic, and other or undetermined causes according to TOAST criteria were excluded from our analysis. Other exclusion factor included no data on lipids and lack of follow-up.\u003c/p\u003e\n\u003cp\u003eAmong the 17,980 patients diagnosed with ischemic stroke according to World Health Organization criteria [17], 3483 were diagnosed with SAO upon admission; thus, the 14,497 patients with non-SAO strokes were excluded from our study. After excluding patients that did not have HDL data on blood lipids collected upon admission,missing follow-up reports or other reasons, 3067 patients with SAO remained that met all the inclusion criteria and were analyzed in the present study (Figure 1). Patients were classified into three subgroups according to age (\u0026lt;45 years, n = 140; \u0026ge;45 and \u0026lt;75 years, n = 2054; \u0026ge;75 years, n = 312).\u003c/p\u003e\n\u003cp\u003ePatients were evaluated for SAO by two experienced neurologists. SAO cases categorized as lacunar infarcts using other classification systems [18] were diagnosed based on the following criteria: The patient exhibited one of the traditional clinical lacunar syndromes without evidence of cerebral cortical dysfunction. Patients also had a relevant brain stem or subcortical hemispheric lesion \u0026lt; 1.5 cm in diameter detected via computed tomography or magnetic resonance imaging. Additionally, no potential cardiac sources for embolism were present and stenosis was less than 50% in an ipsilateral artery. A history of diabetes mellitus or hypertension further supported the clinical diagnosis. All patients included in present study were diagnosed with Small-artery occlusion,those with a poor prognosis for survival (loss of consciousness or severe comorbidities), those with preexisting disabilities of the extremities were excluded from this study.\u003c/p\u003e\n\u003cp\u003eDemographic and clinical assessment\u003c/p\u003e\n\u003cp\u003eBaseline information and stroke risk factors were obtained from a record of clinical history within 24 hours of admission; information included age, sex, medical history, and detailed demographic data. Biochemical variables in the blood were measured following a fasting period of at least eight hours on the first day after admission and were analyzed in a certified central laboratory.\u003c/p\u003e\n\u003cp\u003eHDL values were classified into four quartiles (\u0026lt;0.92, 0.92\u0026ndash;1.08, 1.08\u0026ndash;1.28，and \u0026ge;1.28 mmol/L), since quartile classification is the most common statistical layering method. Hypertension was documented for patients with a systolic blood pressure \u0026ge;140 mmHg and/or diastolic blood pressure \u0026ge; 90 mmHg on the seventh day after stroke onset, systolic and diastolic blood pressures of 140/90 mmHg, and for patients taking antihypertensive medications [15]. Diabetes mellitus was identified in patients with fasting blood glucose levels \u0026ge; 7.0 mmol/L, non-fasting glucose levels \u0026ge; 11.1 mmol/L, a previous diagnosis of diabetes, and/or the use of hypoglycemic agents with a glycated hemoglobin (HbA1c) level \u0026ge; 6.5% at the time of admission [19,20]. Dyslipidemia was characterized in patients being treated with cholesterol-reducing agents as well as in patients with a TG level \u0026gt; 2.26 mmol/L (200 mg/dL) or a TC level \u0026gt; 6.21 mmol/L (240 mg/dL). Individuals who had smoked tobacco products every day for more than a year were defined as current smokers. Alcohol drinkers were defined as those who consumed alcohol at least once per week for more than 1 year. Body mass index (kg/m\u003csup\u003e2\u003c/sup\u003e) was calculated at the time of admission, and obesity was defined as a body mass index \u0026ge; 30 kg/m\u003csup\u003e2\u003c/sup\u003e [21]. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) [22].\u003c/p\u003e\n\u003cp\u003eFunctional outcome and follow-up\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eThe primary outcome was prognoses of patients with SAO (favorable or poor prognoses) during a 12-month period after stroke onset.Secondary outcomes included poor prognoses, and composite of recurrent stroke,myocardial infarction (MI) or vascular death within 12 months. The 12-month follow-up was done by telephone interviews or in-person interviews; all results were recorded into our electronic stroke database immediately to ensure reliability. The modified Rankin scale (mRS) was used to evaluate functional outcomes: mRS scores of 0\u0026ndash;2 represented favorable prognoses and mRS scores of 3\u0026ndash;5 indicated poor prognoses.\u003c/p\u003e\n\u003cp\u003eStatistical analysis\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eIn this study, continuous variables are presented as means \u0026plusmn; standard deviations and categorical variables are reported as counts and proportions. We assessed the significance of intergroup differences using t-tests and one-way analysis of variance tests; chi-squared tests or Fisher\u0026rsquo;s exact tests were used to determine differences between groups. A multiple logistic regression analysis was used to evaluate the relationship between HDL levels and stroke prognoses with mRS scores. Statistical analyses were performed using the Statistical Package SPSS 24.0. All tests were two-sided, and p values \u0026lt; 0.05 were considered statistically significant.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eBaseline demographics and clinical characteristics of study participants\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTable 1 outlines the baseline demographics and clinical characteristics according to the HDL quartiles. The mean HDL level of all patients was 1.126 \u0026plusmn; 0.31 mmol/L (range, 0.25\u0026ndash;6.11 mmol/L). NIHSS scores ranged from 0 to 14. In the present study, we collected data on 3067 patients (2134 men [69.6%]; 933 women [30.4%]). Mean age was 61.94\u0026plusmn;11.08 years. Among them, 29.5% had diabetes and 64.7% had hypertension. There was a statistically significant difference among the stratifications regarding HDL levels and lipid metabolism disorders (p \u0026lt; 0.05). Patients with HDL levels in the highest quartile were less likely to have diabetes (n = 164, 21.2%) and to smoke (n = 267, 34.5%).\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEvaluation of risk factors between groups classified by outcomes\u003c/strong\u003e\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eTable 2 describes the comparison of risk factors between different groups classified by outcomes. Among patients, 2284 (74.5%) had an favorable outcome. As it shows the following factors to be independently associated with the 12-month primary outcomes: age, HDL levels, and NIHSS scores (p \u0026lt; 0.001,p = 0.006,p \u0026lt; 0.001,respectively).Younger patients(60.87\u0026plusmn;10.82) had more favorable outcomes than older patients(64.23\u0026plusmn;11.00).However, there were no significant associations with other risk factors (sex, hypertension, diabetes, smoking, alcohol consumption, and obesity). In addition,of 3067 patients,783(25.5%) had a composite of poor outcomes,recurrent stroke, MI or vascular death within 12 months. Similar to the primary outcome predictors,secondary outcomes were significantly correlated with age, HDL levels, and NIHSS scores(all p values \u0026lt; 0.05).Patiets with favorable outcomes were more likely to be the younger(60.87\u0026plusmn;10.82).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMultivariate logistical regression analyses of HDL groups and outcomes\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTable 3 presents the results of the logistic regression analyses of HDL levels and outcome variables. As shown in the table, HDL levels in the two higher quartiles (1.08\u0026ndash;1.28 , \u0026ge;1.28) were significantly associated with the 12-month primary outcome as compared with the reference of HDL levels in the lowest quartile (adjusted odds ratio, 1.08\u0026ndash;1.28 , 0.587; 95% CI,0.394-0.873; P = 0.009; \u0026ge;1.28, 0.448; 95% CI, 0.291-0.688; P \u0026lt; 0.001). Similar to the primary outcome,with 12-month secondary outcomes, patients with HDL levels in the two higher quartiles (1.08\u0026ndash;1.28 , \u0026ge;1.28) had more favorable outcomes(adjusted odds ratio, 1.08\u0026ndash;1.28 , 0.788; 95% CI, 0.621-0.999; P = 0.049; \u0026ge;1.28, 0.713; 95% CI, 0.560-0.909; P = 0.006).Meanwhile, there was a statistically significant association between age and SAO primary and secondary outcome (both P values \u0026lt; 0.001).\u003c/p\u003e\n\u003cp\u003eTable 4 further shows the association between HDL levels and outcomes according to age. We found a statistically significant direct correlation for the age range of 45\u0026ndash;75 years with the primary outcome of stroke(1.08\u0026ndash;1.28 mmol/L, p = 0.033; \u0026ge;1.28 mmol/L, p = 0.001, respectively).Furthermore,the similar association was found for patients with the secondary outcomes(\u0026ge;1.28 mmol/L, p = 0.001). However, no association was found between outcomes and the lower HDL stratification with the age range of 45\u0026ndash;75 years, neither the primary outcome(0.92\u0026ndash;1.08; p = 0.064) nor the secondary outcomes(0.92\u0026ndash;1.08; p = 0.305).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThe present study analyzed the clinical data of patients with SAO according to different age groups using data obtained from a hospital-based stroke registry from Tianjin, located in northern China. The higher HDL stratification levels (1.08\u0026ndash;1.28, \u0026ge;1.28) were strongly correlated with favorable outcomes of patients with SAO; this clear positive association was observed in patients from 45 to 75 years of age.\u003c/p\u003e\n\u003cp\u003eOur results indicated that elevated HDL cholesterol levels may facilitate a favorable prognosis for patients with SAO. Previous studies have demonstrated that low HDL cholesterol levels were not only associated with the risk of incident stroke, but also with cerebral small vessel disease [19,23,24,25,26]. In addition, both the Japan Public Health Center study (2017) and the Holmes (2018) study reported an inverse relationship between HDL cholesterol levels and SAO. Furthermore, the Holmes (2018) study provided evidence demonstrating that cholesterol ester transfer proteins mediated higher HDL cholesterol levels and were associated with a lower risk of SAO, genetically [19,25,26]. Our results support these study findings; however, a meta-analysis of randomized controlled trials did not show that raising HDL levels will reduce the risk of stroke, but these results could have been affected by off-target effects of the drugs [27]. Moreover, a Framingham study provided no evidence to support a causal relationship between the role of 47 HDL cholesterol single nucleotide polymorphisms and ischemic stroke [28]; however, compared with the 3067 patients in our study, this previous study only involved 301 participants with ischemic stroke. Differences between our study results and previous studies may be due to patient race, age, and analytic strategies; for instance, the percentage of women was higher in the aforementioned Framingham study, 56% [28], compared with the 30.4% of women in our study.\u003c/p\u003e\n\u003cp\u003eOur analysis revealed an inconsistent association between HDL and stroke similar to previous findings concerning cardiovascular disease [29]. Some randomized controlled trials explored the clinical benefits of elevated HDL cholesterol levels for patients diagnosed with cardiovascular disease by adding niacin to statin therapy. One study showed that elevated HDL levels contributed to the regression of angiographic coronary-artery stenoses [30]; however, another study surprisingly reported no clinical benefits after increasing HDL cholesterol levels for patients with cardiovascular disease and failed to provide evidence for a causal link between extended-release niacin and ischemic stroke [29]. Nevertheless, there are no reported clinical studies analyzing the relationship between elevated HDL levels and ischemic stroke or ischemic stroke subtypes; thus, further evaluation is needed to clarify these contradictory findings. Nevertheless, our results are valid and may be used to provide clinical guidance in northern China.\u003c/p\u003e\n\u003cp\u003eAdditionally, our previous studies found that hemoglobin A1c levels and high-sensitivity C-reactive proteins (hs-CRPs) were associated with SAO outcomes [10,31]. Although, hyperglycemia and hs-CRPs may be related to endothelial damage and inflammatory responses, thus leading to the occlusion of deep penetrating vessels, dysglycemia may also intensify lipid disorders that can aggravate the inflammatory responses of vessels. Therefore, these risk factors are independent and interrelated, further signifying the importance of evaluating risk factors related to dyslipidemia in clinical practice.\u003c/p\u003e\n\u003cp\u003eAlthough there is a significant relationship between HDL cholesterol and SAO, the underlying mechanism is not clear. HDL plays a key role in promoting reverse cholesterol transport from the periphery to the liver. Furthermore, mounting evidence has demonstrated that the reverse cholesterol transport process may provide protection from atherosclerosis, which can lead to lacunar infarcts through artery occlusion [26,32]; in fact, some studies found impaired carbon\u0026nbsp;\u003cem\u003edioxide\u003c/em\u003e(CO\u003csub\u003e2\u003c/sub\u003e) vasoreactivity in lacunar infarct patients. While serum HDL cholesterol affects cerebral vasculature CO\u003csub\u003e2\u003c/sub\u003e reactivity by increasing the permeability of the blood-brain barrier, the increased permeability may lead to glial and neuronal damage by allowing blood products to diffuse into the perivascular space[26]. Also, some evidence suggests that HDL cholesterol may activate endothelial nitric oxide synthase to promote endothelial repair, induce angiogenesis, and increase platelet reactivity, anti-inflammatory reactions, and hypercoagulability functions[19,33,34]. Furthermore, modulating HDL levels may be implicated in vascular remodeling and functional recovery [34,35,36].\u003c/p\u003e\n\u003cp\u003eOur study also found that elevated HDL cholesterol levels were associated with favorable prognoses only in patients aged from 45 to 75 years after multivariate adjustment, and this association was presented both in the primary outcome group and the secondary outcomes.Similar to our study,Aleksandra et al found that lower HDL cholesterol levels\u0026nbsp; was significant in middle-aged and elderly persons[23],which may be strongly correlated with the HDL cholesterol\u0026rsquo;s above-mentioned anti-inflammatory and anti-atherogenic pathophysiology。No association was presented between HDL cholesterol levels with SAO outcomes in the oldest-old patients(\u0026ge; 75 years).That might be associate with a higher risk of comorbidity with increasing age, and multiple risk factors acting together may attenuate the impact of any one independent risk or protective factor,such as the protection of HDL cholesterol.Studies have indicated hypertension,hyperglycemia and dyslipidemia were the major risk factors of small artery occlusion in young adults.Nevertheless,the young people have less complication,higher compensatory function and adjustable life style.Controlling weight and alcohol,quit smoking,exercise and good medication compliance can regulate blood pressure,blood glucose and lipid metabolism,which contribute to favorable outcomes in the young.\u003c/p\u003e\n\u003cp\u003eThe clinical information that was collected for a large number of SAO cases, promptly drawn blood samples, and inclusion of adults of any age enhanced the robustness of our study. Our findings suggest the importance of maintaining HDL cholesterol values in higher stratifications using lipid-regulating drugs or proper exercise for patients with SAO. However, there were several limitations to our study. First, we collected clinical information for SAO cases from one hospital in Tianjin; thus the patient population does not represent the general population of China that may otherwise vary by region, diet, lifestyle, and other factors. Furthermore, we did not consider the use of lipid-lowering medications such as statins. The influence of statins on HDL cholesterol values during the follow-up period is unclear and may have affected the outcomes of patients with SAO. In addition, patients without HDL cholesterol data upon at admission were not included in this study, which may have presented a selection bias. Finally, other limitations were those particularly inherent to retrospective studies.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eCI, confidence interval;\u003c/p\u003e\n\u003cp\u003eHbA1c, hemoglobin A1c;\u003c/p\u003e\n\u003cp\u003eHDL-C, High-Density Lipoprotein Cholesterol;\u003c/p\u003e\n\u003cp\u003ehs-CRP, High-Sensitivity C-Reactive Protein;\u003c/p\u003e\n\u003cp\u003eLAA, large-artery atherosclerosis ;\u003c/p\u003e\n\u003cp\u003eLDL-C, Low-Density Lipoprotein Cholesterol;\u003c/p\u003e\n\u003cp\u003emRS, modified Rankin scale;\u003c/p\u003e\n\u003cp\u003eNIHSS ,National Institutes of Health Stroke Scale;\u003c/p\u003e\n\u003cp\u003eOR, odds ratio; \u0026nbsp;\u003c/p\u003e\n\u003cp\u003eSAO, Small-artery occlusion;\u003c/p\u003e\n\u003cp\u003eTOAST, Trial of ORG10172 in Acute Stroke Treatment;\u003c/p\u003e\n\u003cp\u003eTC, Total Cholesterol;\u003c/p\u003e\n\u003cp\u003eTG, Triglycerides\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe Ethics Committee of\u0026nbsp; Tianjin Huanhu Hospital approved the study protocol. All patients consent to participate in this observational study. Written informed consent was obtained from each participant according to the demand of Local Ethics Committee of Tianjin Huanhu Hospital. A written consent could be obtained directly from the patient. In some circumstances that the patient was unable to sign because of hemiplegia, a written consent could be obtained from a family member. The ethics committee approved this procedure.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe datasets analysed during the current study are available from the corresponding author on reasonable request.\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll authors declare that they have no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was generously supported by the National Natural Science Foundation of China\u0026nbsp;(81671169, to J.W), Tianjin Municipal Science and Technology Commission (17JCZDJC36500, to J.W), and Grants from General Administration of Sport of China (2015B098, to J.W). The former two grants supported the design, data collection and analysis of this study, and the latter one supported the interpretation of data and in writing the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors\u0026rsquo; contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eJW took part in design of the study, funding obtained, interpretation of the data and revising the manuscript. RH, PL and YW carried out the studies, participated in collecting data. RH, and PL drafted the manuscript.RH and YW performed the statistical analysis and participated in its design. All authors read and approved the final manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors acknowledge the invaluable participation of the patients.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eKrishnamurthi RV, Feigin VL, Forouzanfar MH, Mensah GA,Connor M, Bennett DA,Moran AE,Sacco RL, Anderson LM,Truelsen T, O'Donnell M, Venketasubramanian N,Barker-Collo S, Lawes CM, Wang W, Shinohara Y, Witt E,Ezzati M, Naghavi M,Murray C; Global Burden of Diseases,Injuries, Risk Factors Study 2010 (GBD 2010); GBD Stroke Experts Group. Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990-2010: findings from the Global Burden of Disease Study 2010. Lancet Glob Health. 2013 Nov;1(5):e259-81.\u003c/li\u003e\n\u003cli\u003eHata J, Kiyohara Y. Epidemiology of stroke and coronary artery disease in Asia. 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Cerebrovasc Dis. 2009;27(5):519-26.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003eTable 1 - Baseline demographics and clinical characteristics according to\u003c/strong\u003e\u003cstrong\u003e HDL \u0026nbsp;\u003c/strong\u003e\u003cstrong\u003egroups\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; margin-left: 6.0pt; margin-right: 6.0pt;\" width=\"710\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 171.85pt; border: none; border-top: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; border: none; border-top: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 439.45pt; border: none; border-top: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"7\" width=\"439\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eQuartile of HDL , mmol/L\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; border: none; border-top: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 23.25pt;\"\u003e\n\u003ctd style=\"width: 171.85pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 23.25pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 23.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.25pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026lt;0.92 (\u003cem\u003en \u003c/em\u003e=733)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.25pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.92 to \u0026lt; 1.08 (\u003cem\u003en \u003c/em\u003e=768)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.25pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e1.08 to \u0026lt; 1.28 (\u003cem\u003en \u003c/em\u003e= 791)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 23.25pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026ge; 1.28 (\u003cem\u003en \u003c/em\u003e=775)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 23.25pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eP\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 171.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eAge, years (median values)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e61.42\u0026plusmn;11.28\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e62.39\u0026plusmn;11.26\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e61.98\u0026plusmn;10.89\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e61.95\u0026plusmn;10.87\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.409\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 171.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eMale sex, n(%)*\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e542(73.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e511(66.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e528(66.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e553(71.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.003\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 171.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eRisk factors\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 171.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eHypertension, n(%)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e490(66.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e479(62.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e525(66.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e489(63.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.162\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 171.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003eDiabetes, n(%)*\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e305(41.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e213(27.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e223(28.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e164(21.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 171.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eSmokers, n(%)*\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e305(41.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e297(38.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e302(38.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e267(34.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.040\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 171.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eAlcohol drinkers, n(%)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e120(16.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e116(15.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e126(15.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e125(16.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.915\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 171.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eObesity, n(%)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e54(7.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e48(6.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e53(6.7)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e37(4.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.194\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 171.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eLaboratory findings\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 171.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eTG, mmol/L(median values)*\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.09\u0026plusmn;1.48\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.76\u0026plusmn;1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.58\u0026plusmn;0.88\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.46\u0026plusmn;0.96\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 171.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eTC, mmol/L(median values)*\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4.59\u0026plusmn;1.82\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4.87\u0026plusmn;0.95\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e5.05\u0026plusmn;0.98\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e5.39\u0026plusmn;1.06\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 171.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eHDL-C, mmol/L(median values)*\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: red; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.79\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.97\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.99\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.45\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e1.17\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.56\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e1.53\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.30\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 171.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eLDL-C, mmol/L(median values)*\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.68\u0026plusmn;0.79\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.90\u0026plusmn;0.78\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.96\u0026plusmn;0.79\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e3.02\u0026plusmn;0.85\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 171.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eNIHSS, n(%)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: red; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.526\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 171.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: right; line-height: 150%; tab-stops: 91.65pt 93.9pt;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 0-6\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: red; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e538(73.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e548(71.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e570(72.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e577(74.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 171.85pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"172\"\u003e\n\u003cp style=\"text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; 7-14\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: red; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e195(26.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e220(28.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 113.4pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"113\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e221(27.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e198(25.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.0pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u0026nbsp;* Indicates P\u0026lt; 0.05 when comparing between four groups.\u0026nbsp;TC, total cholesterol; TG, triglyceride; HDL, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol;NIHSS, National Institute of Health stroke scale\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003eTable 2 - Comparison of the risk factors between different groups classified by outcomes\u003c/strong\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse;\" width=\"730\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 155.7pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" rowspan=\"2\" width=\"156\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; border: none; border-top: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003emRS\u0026le;2\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003emRS\u0026ge;3\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" rowspan=\"2\" width=\"71\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cem\u003eP\u003c/em\u003e Value\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; border: none; border-top: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.35pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003emRS\u0026le;2\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eComposite endpoints\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" rowspan=\"2\" width=\"71\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cem\u003eP\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e Value\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 14.15pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e(\u003cem\u003en\u003c/em\u003e=2284)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e(\u003cem\u003en\u003c/em\u003e=222)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.35pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e(\u003cem\u003en\u003c/em\u003e=2284)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e(\u003cem\u003en\u003c/em\u003e=783)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 155.7pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"156\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eAge, years (median values)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e60.87\u0026plusmn;10.82\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e64.23\u0026plusmn;11.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.35pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e60.87\u0026plusmn;10.82\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e65.08\u0026plusmn;11.23\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 155.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"156\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eMale sex, n(%)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1596(69.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e142(64.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.068\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.35pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e1596\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e69.9\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e538\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e68.7\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.540\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 155.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"156\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eHypertension, n(%)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1482(64.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e135(60.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.226\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.35pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e1482\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e64.9\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e501\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e64.0\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.649\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 155.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"156\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eDiabetes, n(%)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e660(28.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e74(33.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.166\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.35pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e660\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e28.9\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e245\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e31.3\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.205\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 155.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"156\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eSmokers, n(%)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e868(38.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e78(35.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.400\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.35pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e868\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e38.0\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e303\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e38.7\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.730\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 155.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"156\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eAlcohol drinkers, n(%)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e366(16.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e34(15.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.783\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.35pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e366\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e16.0\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e121\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e15.5\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.706\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 155.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"156\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eObesity, n(%)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e151(6.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e13(5.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.664\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.35pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e151\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e6.6\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e41\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e5.2\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.171\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 155.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"156\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eHDL, n(%)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.006\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.35pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.037\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 155.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"156\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026lt;0.92\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e527(23.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e69(31.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.35pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e527\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e23.1\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e206\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e26.3\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 155.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"156\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026ge;0.92\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e558(24.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e60(27.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.35pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e558\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e24.4\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e210\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e26.8\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 155.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"156\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026ge;1.08\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e597(26.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e54(24.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.35pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e597\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e26.1\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e194\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e24.8\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 155.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"156\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026ge;1.28\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e602(26.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e39(17.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.35pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e602\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e26.4\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e173\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e22.1\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 155.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"156\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eNIHSS, n(%)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.35pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 155.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"156\"\u003e\n\u003cp style=\"text-align: right; line-height: 150%; tab-stops: 91.65pt 93.9pt;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e0-6\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1795(78.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e75(33.8)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.35pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e1795\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e78.6\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e438\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e55.9\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 155.7pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"156\"\u003e\n\u003cp style=\"text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026ge; 7\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.25pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e489(21.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e147(66.2)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.15pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.35pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e489\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e21.4\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 99.2pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e345\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e44.1\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-indent: 27.0pt; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003emRS: modified Rankin scale; \u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003eNIHSS: \u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003eNational Institute of Health stroke scale;HDL, high-density lipoprotein cholesterol;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-indent: 27.0pt; line-height: 150%;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003eTable 3 - Multivariate logistical regression analyses of HDL groups and the outcome variables\u003c/strong\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse;\" width=\"517\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 104.05pt; border: none; border-top: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 13.85pt; border: none; border-top: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 185.85pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"186\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003ePrimary outcome\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 11.8pt; border: none; border-top: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.8in; border: none; border-top: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" colspan=\"2\" width=\"202\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eSecondary outcome\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 104.05pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 13.85pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.65pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"107\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eOR ( 95% CI )\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.1in; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"79\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 150%;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e Value\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 11.8pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.55pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"117\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eOR ( 95% CI )\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 150%;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e Value\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 104.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eAge\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 13.85pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"107\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.026(1.012-1.039)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.1in; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"79\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 11.8pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.55pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"117\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e1.034\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e1.026-1.042\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 104.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003eHDL\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 13.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.65pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"107\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.1in; padding: 0in 5.4pt 0in 5.4pt;\" width=\"79\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 11.8pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.55pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"117\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 104.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: right;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u0026lt;0.92\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 13.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.65pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"107\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eindex\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.1in; padding: 0in 5.4pt 0in 5.4pt;\" width=\"79\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eindex\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 11.8pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.55pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"117\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eindex\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eindex\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 104.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: right;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u0026ge;0.92\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 13.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.65pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"107\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.706(0.478-1.042)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.1in; padding: 0in 5.4pt 0in 5.4pt;\" width=\"79\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.079\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 11.8pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.55pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"117\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.901\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.712-1.140\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.386\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 104.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: right;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u0026ge;1.08\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 13.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.65pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"107\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.587(0.394-0.873)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.1in; padding: 0in 5.4pt 0in 5.4pt;\" width=\"79\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.009\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 11.8pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.55pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"117\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.788\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.621-0.999\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.049\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 104.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: right;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u0026ge;1.28\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 13.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.65pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"107\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.448(0.291-0.688)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.1in; padding: 0in 5.4pt 0in 5.4pt;\" width=\"79\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 11.8pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.55pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"117\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.713\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.560-0.909\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.006\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 104.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eNIHSS\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 13.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.65pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"107\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.1in; padding: 0in 5.4pt 0in 5.4pt;\" width=\"79\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 11.8pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.55pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"117\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 104.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e0-6\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 13.85pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.65pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"107\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eindex\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.1in; padding: 0in 5.4pt 0in 5.4pt;\" width=\"79\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eindex\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 11.8pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.55pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"117\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eindex\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eindex\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 104.05pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026ge; 7\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 13.85pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"14\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.65pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"107\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e7.165(5.314-9.660)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 1.1in; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"79\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 11.8pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"12\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 116.55pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"117\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e2.796\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e2.345-3.333\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003emRS: modified Rankin scale; NIHSS: National Institute of Health stroke scale;HDL, high-density lipoprotein cholesterol;\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003eTable 4 - Multivariate logistical regression analyses of HDL groups classified by age and outcomes\u003c/strong\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; margin-left: 6.0pt; margin-right: 6.0pt;\" width=\"733\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 17.25pt;\"\u003e\n\u003ctd style=\"width: 70.65pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.95pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.3pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eOR(95%CI)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 150%;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e Value\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"120\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eOR(95%CI)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 150%;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e Value\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 109.4pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"109\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eOR(95%CI)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border-top: solid windowtext 1.5pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 150%;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e Value\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.25pt;\"\u003e\n\u003ctd style=\"width: 70.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 163.0pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" colspan=\"2\" width=\"163\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026lt; 45 (\u003cem\u003en\u003c/em\u003e=140)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 184.25pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" colspan=\"2\" width=\"184\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e45 to \u0026lt;75 (\u003cem\u003en\u003c/em\u003e=2054)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 173.2pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" colspan=\"2\" width=\"173\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026ge; 75 (\u003cem\u003en\u003c/em\u003e=312)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.25pt;\"\u003e\n\u003ctd style=\"width: 70.65pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" rowspan=\"8\" width=\"71\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003ePrimary outcome\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.95pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eHDL\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"120\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 109.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"109\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.25pt;\"\u003e\n\u003ctd style=\"width: 98.95pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026lt; 0.92\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eindex\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"120\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eindex\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 109.4pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"109\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eindex\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.25pt;\"\u003e\n\u003ctd style=\"width: 98.95pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026ge; 0.92\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.585(0.049-6.971)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.672\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"120\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.650(0.411-1.026)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.064\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 109.4pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"109\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.977(0.434-2.202)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; 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border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 34.2pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 34.2pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 109.4pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 34.2pt;\" width=\"109\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e3.937(2.060-7.524)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 34.2pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.25pt;\"\u003e\n\u003ctd style=\"width: 70.65pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"71\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%; color: red;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.95pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%; color: red;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 163.0pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" colspan=\"2\" width=\"163\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026lt; 45 (\u003cem\u003en\u003c/em\u003e=156)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 184.25pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" colspan=\"2\" width=\"184\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e45 to \u0026lt;75 (\u003cem\u003en\u003c/em\u003e=2462)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 173.2pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" colspan=\"2\" width=\"173\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026ge; 75 (\u003cem\u003en\u003c/em\u003e=449)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.25pt;\"\u003e\n\u003ctd style=\"width: 70.65pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" rowspan=\"9\" width=\"71\"\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eSecondary outcome\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 98.95pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eAge\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.3pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.984\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e（\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.889-1.089\u003c/span\u003e\u003cspan style=\"line-height: 150%;\"\u003e）\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.756\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"120\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.026(1.013-1.038)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 109.4pt; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"109\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.056(1.001-1.115)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.046\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.25pt;\"\u003e\n\u003ctd style=\"width: 98.95pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eHDL\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"120\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 109.4pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"109\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.25pt;\"\u003e\n\u003ctd style=\"width: 98.95pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"99\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026lt; 0.92\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.3pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"106\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eindex\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"57\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.45pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"120\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eindex\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 14.2pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"14\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; 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border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"109\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.119(1.424-3.155)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.8pt; border: none; border-bottom: solid windowtext 1.5pt; padding: 0in 5.4pt 0in 5.4pt; height: 17.25pt;\" width=\"64\"\u003e\n\u003cp style=\"text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-indent: 13.5pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003emRS: modified Rankin scale; NIHSS: National Institute of Health stroke scale;HDL, high-density lipoprotein cholesterol;\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"High-Density Lipoprotein Cholesterol, Stroke, Outcome, Small-Artery Occlusion","lastPublishedDoi":"10.21203/rs.2.294/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.294/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground: \u003c/strong\u003eThe relationship between high-density lipoprotein (HDL) cholesterol and small-artery occlusion (SAO) is not well understood.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e \u0026nbsp;A total of 3067 consecutive patients with SAO were recruited from Tianjin Huanhu Hospital between January 01, 2008, and December 31, 2015. HDL values at admission were classified into four groups according to quartiles (\u0026lt;0.92, 0.92–1.08, 1.08–1.28, and ≥1.28). Patients were followed up to 12 months after stroke. Prognoses, represented by modified Rankin scale (mRS), were estimated via HDL quartiles upon admission utilizing multivariate logistic regression analysis. Meanwhile, we conducted additional subgroup analyses to investigate associations according to age.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003eAmong 3067 patients, 2284(74.5%) were classified as having favorable outcomes, 783(25.5%) had a composite of poor outcomes,recurrent stroke, myocardial infarction or vascular death within 12 months. After adjustment for possible confounders, HDL levels in the two highest quartiles (1.08–1.28 and ≥1.28) were correlated with the 12-month primary outcome of patients with SAO (1.08–1.28 , 0.587; 95% CI,0.394-0.873; P = 0.009; ≥1.28, 0.448; 95% CI, 0.291-0.688; P \u0026lt; 0.001). However, a direct correlation was found in patients aged 45–75 years (1.08–1.28, P = 0.033; ≥1.28, P = 0.001).Similar to the primary outcome,a direct correlation was also found in patients aged 45–75 years with a 12-month secondary outcomes(≥1.28 mmol/L, p = 0.001).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions: \u003c/strong\u003eAn elevated HDL cholesterol level in patients with SAO is an independent predictor of a favorable prognosis 12 months after SAO. However, the association was only present in patients aged 45–75 years.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eKeywords:\u003c/strong\u003e High-Density Lipoprotein Cholesterol, Stroke, Outcome, Small-Artery Occlusion.\u003c/p\u003e","manuscriptTitle":"An Elevated High-Density Lipoprotein Cholesterol Levels Is Associated with Favorable Outcomes of Patients with Small-Artery Occlusion","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2019-03-06 12:49:20","doi":"10.21203/rs.2.294/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"c105cb67-3bd6-4046-a92b-be191035c818","owner":[],"postedDate":"March 6th, 2019","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":650,"name":"Internal Medicine Specialties"}],"tags":[],"updatedAt":"","versionOfRecord":[],"versionCreatedAt":"2019-03-06 12:49:20","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-294","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-294","version":["v1"]},"buildId":"7rjqhiLT3MXkJMwkYKINL","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}