Haemodynamic Analysis of Single And Double Bare-metal Stents For Coronary Artery Aneurysm

Abstract Background The aim of this study was to investigate a novel method to treat coronary artery aneurysms(CAAs).Methods Three CAAs patients who underwent single or double bare-metal stent implantation were recruited. The CAAs and parent artery diameters were measured for model construction. Single- and double-stent implantation were simulated, and the changes in the CAAs haemodynamics after stenting were analysed. Results In Case 1, the flow velocity in the single-stent model was significantly lower than that in the double-stent model (0.0046±0.013 vs 0.0050±0.011, p<0.001), while the pressure (127.33±18.03 vs 121.19±26.92, p<0.001) and wall shear stress (WSS, 0.28±1.19 vs 0.22±1.13, p<0.001) were significantly higher. In Case 2, the flow velocity (0.005±0.011 vs 0.007±0.01, p<0.001) and WSS (0.17±0.82 vs 0.23±0.88, p<0.001) in the double-stent model were significantly lower than those in the single-stent model, while the pressure was significantly higher(117.70±10.07 vs 110.64±6.34, p<0.001). The same tendency was also observed in Case 3. All CAAs occluded during the follow-up period without obvious in-stent restenosis.Conclusion Application of the single or double bare-metal stent technique, according to the neck diameter of the coronary artery aneurysms, can effectively change the flow in vessels and aneurysm haemodynamics to achieve occlusion.Trail registration: Clinicaltrails, NCT04265989. Registered 12 February 2020, https://clinicaltrials.gov/ct2/show/NCT04265989?term=NCT04265989&draw=2&rank=1