Nociceptor-macrophage crosstalk in endometriosis: insights into pain and disease progression

Michael S. Rogers
In: The Biomedical & Life Sciences Collection · 2025 · vol. 2025(8) , pp. e1008360 · doi:10.69645/djrk7223 · W4413856106
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This multimedia lecture explores the interaction between nociceptors and macrophages in endometriosis, providing insights into pain mechanisms and disease progression.

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This presentation by Dr. Michael S. Rogers explores the molecular mechanisms linking nociceptors and macrophages in endometriosis, specifically focusing on neuroimmune communication and pain pathways. The work highlights the role of Calcitonin Gene–related Peptide (CGRP) signaling through the RAMP1 receptor in driving pathological angiogenesis and associated disease progression. While the talk covers broader topics such as gynecological inflammatory diseases and potential therapeutic targets like pomalidomide, the central narrative examines how these cellular interactions contribute to the clinical symptoms of endometriosis. This paper is centrally about endometriosis — specifically investigating the crosstalk between nociceptors and macrophages that drives pain and disease progression.

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Abstract

Click to launch & play an online audio visual presentation by Dr. Michael S. Rogers on Nociceptor-macrophage crosstalk in endometriosis: insights into pain and disease progression, part of a collection of multimedia lectures.
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We noted you are experiencing viewing problems - Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443. - Check the following talk links to see which ones work correctly: Auto Mode HTTP Progressive Download Send us your results from the above test links at [email protected] and we will contact you with further advice on troubleshooting your viewing problems. - No luck yet? More tips for troubleshooting viewing issues - Contact HST Support [email protected] - Please review our troubleshooting guide for tips and advice on resolving your viewing problems. - For additional help, please don't hesitate to contact HST support [email protected] We hope you have enjoyed this limited-length demo Topics Covered - Gynecological inflammatory disease - Endometriosis - Neuroimmune communication - Calcitonin Gene–related Peptide (CGRP) - Receptor Activity Modifying Protein 1 (RAMP1) - CGRP/RAMP1 signalling Biography Dr. Michael S. Rogers is an Assistant Professor of Surgery at Harvard Medical School and a Principal Investigator in the Vascular Biology Program at Boston Children’s Hospital. His research focuses on the molecular mechanisms of angiogenesis, particularly in diseases such as cancer and endometriosis. He is noted for his contributions to the development of pomalidomide, an FDA-approved drug for multiple myeloma, and for uncovering roles of the anthrax toxin receptor CMG2 in blood vessel growth and pain pathways. Dr. Rogers earned his Ph.D. from the Mayo Clinic and has been a key educator in Harvard’s medical curriculum, where he is recognized for his teaching and mentorship. His laboratory continues to explore novel therapeutic targets aimed at controlling pathological angiogenesis and associated pain. Links Series: Categories: Therapeutic Areas: External Links Talk Citation Rogers, M.S. (2025, August 31). Nociceptor-macrophage crosstalk in endometriosis: insights into pain and disease progression [Audio file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 27, 2026, from https://doi.org/10.69645/DJRK7223.Export Citation (RIS) Publication History - Published on August 31, 2025 Financial Disclosures - Dr. Michael S. Rogers has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.

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endometriosis

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