The influence of socio-psychological factors, adverse effects of hormone therapy on the refusal of patients from its implementation or interruption of therapy after surgical treatment of ovarian endometriosis

E. Yu. Zhilnio, И. А. Салов, В. М. Кулешов, Iuliia Naumova
In: Russian Bulletin of Obstetrician-Gynecologist · 2026 · vol. 26(4) , pp. 55 · doi:10.17116/rosakush20262604155 · W7204270044
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This study investigates the socio-psychological factors and adverse effects of hormone therapy that lead patients to refuse or interrupt treatment following surgical intervention for ovarian endometriosis. The research highlights how emotional regulation difficulties, such as alexithymia, and side effects significantly impact medication adherence in this specific patient population. A key limitation noted is the reliance on self-reported data regarding adherence and psychological status, which may introduce bias into the findings. This paper is centrally about endometriosis — specifically focusing on post-surgical hormonal management and patient compliance issues related to ovarian lesions.

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Abstract

Objective. To analyze the role of socio-psychological factors and undesirable effects of hormone therapy on the patient’s refusal to undergo it or discontinue therapy after surgical treatment for ovarian endometriosis. Materials and methods. A prospective study is presented in which the frequency of refusals of patients and the frequency of interruption of anti-relapse hormone therapy after surgical treatment for ovarian endometriosis in the gynecological department of Saratov City Clinical Hospital No. 8 during the period from 2021 to 2025 was evaluated. The study included 133 patients aged 18 to 35 years who underwent surgery for ovarian endometriosis. Combined oral contraceptives were used to prevent the recurrence of endometriosis, according to existing recommendations (ROAG Clinical Recommendations, 2024). Before starting the study, all patients had the severity of alexithymia (Toronto Alexithymia Scale), adherence to treatment (KOP-25 questionnaire), and the indicator of autonomic dysfunction syndrome according to the Wein’s questionnaire. During the first 6 months of taking the drug, patients contacted a doctor who determined the tactics of further treatment when adverse events occurred during treatment. The Statistics IBM SPSS software package for Windows, version 28.0 (Armonk, NY, IBM Corp.) is used for statistical processing of the research results. Results. The risk of adverse events of hormone therapy in the group of women over 30 years of age compared with younger age was comparable: 35.7% and 28.5% (p=0.449). In the absence of autonomic dysfunction syndrome, undesirable phenomena were reported in 18.5% of cases, and in 55.7% of cases with the syndrome (p<0.001). The incidence of complications of hormone therapy did not significantly differ in the subjects with low and high alexithymia values and amounted to 28.5% and 42.8%, respectively (p=0.116). The frequency of treatment failure for subjective and objective reasons in the group of low adherence and high alexithymia was statistically significantly higher than in the groups with high adherence and low alexithymia (p=0.030 and p=0.016, respectively). Conclusion. The presence of signs of autonomic dysfunction syndrome is a significant risk factor for the development of adverse events of anti-relapse hormone therapy. An analysis of the reasons for refusal and interruption of hormone therapy after surgery shows that they are associated with low adherence to treatment (52 units).
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Сайт издательства «Медиа Сфера» содержит материалы, предназначенные исключительно для работников здравоохранения. Закрывая это сообщение, Вы подтверждаете, что являетесь дипломированным медицинским работником или студентом медицинского образовательного учреждения. Результаты поиска: 0 Влияние социально-психологических факторов, нежелательных явлений гормональной терапии на отказ пациенток от ее проведения или прерывание ими терапии после хирургического лечения эндометриоза яичников Журнал: Российский вестник акушера-гинеколога. 2026;26(4): 55‑61 Прочитано: 51 раз Как цитировать: Литература / References: - Vannuccini S, Clemenza S, Rossi M, Petraglia F. Hormonal treatments for endometriosis: The endocrine background. Rev Endocr Metab Disord. 2022;23:3:333-355. https://doi.org/10.1007/s11154-021-09666-w - Thiel PS, Donders F, Kobylianskii A, Maheux-Lacroix S, Matelski J, Walsh C, Murji A. The effect of hormonal treatment on ovarian endometriomas: A Systematic review and meta-analysis. 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