Effectiveness and Safety Evaluation of Microresection of Vestibular Schwannoma After Gamma Knife Treatment

Abstract PURPOSEWe aimed to explored the influence of preoperative gamma knife treatment on the clinical effect of microsurgical resection of vestibular schwannoma.METHODSThe patients who underwent vestibular schwannoma resection in our hospital between November 2010 and December 2019 were retrospectively collected. According to retrospectively collected data, the patients who met the inclusion and exclusion criteria were defined as group A. The 1:3 ratio design was adopted in this study to select the group B that was not subjected to gamma knife treatment in the same period. The pre/postoperative clinical manifestations, neurological function grade, postoperative complications, tumor recurrence and increase were collected and compared between the two groups.RESULTSThere were 40 patients in group A and 120 patients in group B. At the last follow-up, the number of patients with poor facial nerve function was 15 (39.5%) in group A and 25 (21.2%) in group B (P = 0.025). In group A and group B, disequilibrium occurred in 14 patients and 17 patients respectively after operation (P=0.003). 7 patients caught the pulmonary infection in group A and 3 patients had a pulmonary infection in group B (P=0.03) after operation. CONCLUSIONSwhen a patient with vestibular schwannoma undergoes microsurgical surgery, the preoperative history of gamma knife treatment will make a recovery from postoperative facial paralysis difficult for the patients, making them more prone to suffer from postoperative disequilibrium and postoperative pulmonary infection.