Shorter ovarian stimulation is detrimental to fresh embryo transfer outcomes in PCOS women undergoing GnRH antagonist protocol 

Shorter ovarian stimulation is detrimental to fresh embryo transfer outcomes in PCOS women undergoing GnRH antagonist protocol | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Help Center Sign In Submit a Preprint Cite Share Download PDF Article Shorter ovarian stimulation is detrimental to fresh embryo transfer outcomes in PCOS women undergoing GnRH antagonist protocol Shan Xiao, Ling Hong, Zhiqiang Liu, Rui Jia, Hongzhan Zhang, Meilan Mo, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4116372/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 01 Jul, 2025 Read the published version in Scientific Reports → Version 1 posted 9 You are reading this latest preprint version Abstract Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder with dysfunctional ovulation affecting female fertility. The purpose of this study was to determine the association between gonadotropin(Gn) duration and in vitro fertilization (IVF) outcomes in PCOS women undergoing GnRH antagonist treatment. Methods: Retrospective cohort study at a large private fertility practice. Patients with PCOS undergoing the GnRH-antagonist treatment between January 1, 2017, and July 31, 2021 were included. Patients were classified into two groups depending on their Gn duration, ≤8 days （ n=501 ） and ＞ 8 days （ n=1326). The primary outcomes measures included the clinical pregnancy, ongoing pregnancy and live birth rate between the two groups after fresh embryo transfer. In addition, the embryo quality was also evaluated. Result(s): There was no significant difference in baseline characteristics between groups. However, the total Gn dosage was lower in PCOS women in the ≤8 days group. In addition, the oocytes retrieved,2PN embryos and D3 high quality embryos were compared between groups. The clinical pregnancy rate, ongoing pregnancy and live birth rate were significantly decreased in the ≤8 days group in fresh embryo transfer（50.00% vs % 66.20%, 45.56% vs 59.08%,40.00% vs 56.49% ). After logistic regression, PCOS women with Gn duration ≤8 days were associated with poor clinical pregnancy，ongoing pregnancy and live birth rate. Conclusion(s): PCOS women with shorter Gn duration(≤8 days) were not associated with impaired embryo outcomes in GnRH antagonist protocol. However, the shorter Gn stimulation was detrimental to clinical pregnancy outcomes in fresh embryo transfer cycle. Health sciences/Endocrinology/Endocrine system and metabolic diseases Health sciences/Risk factors Biological sciences/Physiology/Reproductive biology PCOS in vitro fertilization GnRH- antagonist ovarian stimulation pregnancy outcomes Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 01 Jul, 2025 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Revision requested 08 Nov, 2024 Reviews received at journal 17 May, 2024 Reviewers agreed at journal 16 May, 2024 Reviewers agreed at journal 16 May, 2024 Reviewers invited by journal 16 May, 2024 Editor assigned by journal 16 May, 2024 Editor invited by journal 12 May, 2024 Submission checks completed at journal 12 May, 2024 First submitted to journal 17 Mar, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4116372","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":303835573,"identity":"db71551b-a31b-45b0-95ec-b3bccbccc878","order_by":0,"name":"Shan Xiao","email":"","orcid":"","institution":"Shenzhen Zhongshan Obstetrics \u0026 Gynecology Hospital (formerly Shenzhen Zhongshan Urology Hospital)","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Shan","middleName":"","lastName":"Xiao","suffix":""},{"id":303835574,"identity":"8ae2ed31-0466-4d77-975b-4ee4f26a2ad1","order_by":1,"name":"Ling 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The purpose of this study was to determine the association between gonadotropin(Gn) duration and in vitro fertilization (IVF) outcomes in PCOS women undergoing GnRH antagonist treatment.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e Retrospective cohort study at a large private fertility practice. Patients with PCOS undergoing the GnRH-antagonist treatment between January 1, 2017, and July 31, 2021 were included. Patients were classified into two groups depending on their Gn duration, ≤8 days （ n=501 ） and ＞ 8 days （ n=1326). The primary outcomes measures included the clinical pregnancy, ongoing pregnancy and live birth rate between the two groups after fresh embryo transfer. In addition, the embryo quality was also evaluated.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResult(s):\u003c/strong\u003e There was no significant difference in baseline characteristics between groups. However, the total Gn dosage was lower in PCOS women in the ≤8 days group. 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