Female Infertility: Cardiovascular Disease Risk Factor or Marker of a Population at Cardiovascular Risk?

Agnaldo Lopes da Silva Filho, Rivera IR, de Oliveira GMM
Arquivos brasileiros de cardiologia · 2026 · doi:10.36660/abc.20250250 · PMID:42484207 · PMC13399457
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This paper examines whether female infertility serves as a cardiovascular disease risk factor or a marker for a population at increased cardiovascular risk, noting its global prevalence and multiple identifiable causes.

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This paper reviews the global prevalence of female infertility, noting that approximately 17.5% of adults are affected and identifying identifiable causes in 85% of cases. It examines whether infertility serves as an independent risk factor for cardiovascular disease or merely acts as a marker indicating a population with heightened cardiovascular risk. The text highlights that while many causes are treatable, the relationship between reproductive health and long-term cardiac outcomes remains a critical area of public health investigation. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Arq. Bras. Cardiol. 2026; 123(5): e20250250 Infertilidade Feminina: Fator de Risco para Doenças Cardiovasculares ou Marcador de uma População com Risco Cardiovascular? Segundo a Organização Mundial da Saúde, aproximadamente 17,5% da população adulta (1 em cada 6 pessoas ao redor do mundo) é afetada pela infertilidade, definida como a incapacidade de conceber após 12 meses de relações sexuais regulares sem proteção. A prevalência varia pouco entre as regiões mundiais, com taxas semelhantes em países de alta, média e baixa renda, constituindo um problema global de saúde pública. Aproximadamente 85% dos casais inférteis têm uma causa identificável para a infertilidade, enquanto os 15% restantes apresentam infertilidade inexplicada. Conforme ilustrado na , a infertilidade pode ser atribuída a múltiplas causas e fatores de risco, cujo tratamento pode eventualmente contribuir para a fertilidade do casal. […] Palavras-chave: Doença Cardiovascular; Fator de Risco; Infertilidade; Sexo Feminino 103

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last seen: 2026-09-27T09:11:36.575535+00:00
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