Vertebral body height changes in acute symptomatic osteoporotic vertebral compression fractures treated with vertebral cement augmentation. Which factors affect vertebral body height?

Vertebral body height changes in acute symptomatic osteoporotic vertebral compression fractures treated with vertebral cement augmentation. 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Which factors affect vertebral body height? Jesús Payo-Ollero, Rafael Llombart-Blanco, Carlos Villas, Matías Alfonso This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-430234/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Changes in vertebral body height depend on various factors which were analyzed in isolation and not as a whole. The aim of this study is to analyze what factors might influence restoration of vertebral body height after vertebral augmentation. We analyzed 48 patients (108 vertebrae) with osteoporotic vertebral fractures underwent vertebral augmentation when conservative treatment proved unsatisfactory. Analyses were carried out at the time of the fracture, during surgery (pre-cementation and post-cementation), at first medical check-up (6 weeks post-surgery) and at last medical check-up. Average vertebral height was measured and differences from preoperative values calculated at each timepoint. Pearson correlation coefficient and linear multivariable regression were carried out at the different timepoints. The time since vertebral fracture was 60.4 ± 41.7 days. Patients’ average age was 70.9 ± 9.3-years. The total follow-up was 1.43 ± 1-year. After vertebral cementation there was an increase in vertebral body height of + 0.3cm (13.6%). During post-operative follow-up, there was a progressive collapse of the vertebral body and pre-surgical height was reached. The factors that most influenced vertebral height restoration were: grade III collapse, intervertebral-vacuum-cleft (IVVC), and use of a flexible trocar before cement augmentation. The factor that negatively influenced vertebral body height restoration was location in the thoracolumbar spine. Rheumatology Orthopedics Vertebroplasty Osteoporosis Vertebral compression fractures Radiography Pain Figures Figure 1 Figure 2 Introduction Different meta-analyzes compared percutaneous vertebroplasty (PVP) with conservative treatment for osteoporotic vertebral compression fractures (OVCFs), reaching the conclusion that PVP achieves greater pain relief, greater functional recovery and better quality of life during the first post-operative year 1 – 3 . Although vertebral height restoration is not an objective of PVP, numerous studies showed that there is an increase in vertebral body height after PVP of 1.2-2.3mm 4 – 9 . However, increase in vertebral body height is frequently calculated comparing pre and postsurgical measurements, which means that changes because of the patient's position (standing to prone position) are not taken into account, and could bias the vertebral augmentation effect 4,7,9−11 . Increase in vertebral body height depends on different factors. Dynamic mobility, conditioned by the patient’s position, is the change in the vertebral body height when the patient goes from standing to supine or prone position, and constitutes one of the most important factors 8,12−16 . The type of vertebral fracture (wedge, biconcave or burst) determines which area of ​​the vertebral body (anterior, middle, or posterior) experiences greater mobility 7 , 9 , 15 . Vertebral fractures of the thoracolumbar region have greater mobility than those in the thoracic region or lumbar region 14 , 15 . Percutaneous kyphoplasty (PKP) achieves greater restoration of vertebral height than PVP 5 , 6 . The presence of intervertebral vacuum cleft (IVVC) is another important factor 8 , 9 , and these clefts are usually located in the thoracolumbar region. All these factors are generally analyzed in isolation and not as a whole, so the surgeon does not really know when these factors may exert an influence during patient follow-up. The aim of this study is to specify the factors influencing restoration of vertebral body height after PVP, from the vertebral body fracture until the patient is definitively discharged. Materials And Methods Approval for this prospective study was given by the Regional Ethical Review Board at our institution (University of Navarra, reference code, 2018.044). Before participating, all patients gave written consent to participate in this study after having received oral and written information. In addition, the study was conducted in accordance with the 1975 Helsinky Declaration, revised in 2013. Patient selection Our cohort consisted of patients who had been treated for acute painful OVCFs and who met the inclusion criteria over the period February 2015 to February 2020. Recruitment criteria were: acute painful OVCFs, failure of conservative treatment (non-steroidal anti-inflammatory drugs, soft orthosis and lumbar exercises), progressive collapse of the vertebral body, reproducible pain at the level of the fractured vertebra, with either current MRI showing bone edema on the STIR sequence or cement augmentation without instrumentation. The patients were excluded if they did not meet inclusion criteria, if they had a vertebral fracture secondary to oncological disease, or if cement augmentation was associated with instrumentation. Of 50 patients (117 vertebrae) treated with cement augmentation, 2 (9 vertebrae) were excluded because they were lost to follow-up. Finally, 48 patients (108 vertebrae) were included. Eighty-eight vertebrae were treated with percutaneous vertebroplasty (DePuy Synthes, Oberdorf, Switzerland) and twenty vertebrae were treated with a flexible trocar StabiliT® MX System (DFine, San José, USA). All patients underwent conventional AP/Lateral X-Rays as well as MRI pre-surgery. The location of the treated vertebrae was as follows: T5 (n = 2), T6 (n = 9), T7 (n = 9), T8 (n = 10), T9 (n = 6), T10 (n = 6), T11 (n = 5), T12 (n = 10), L1 (n = 10), L2 (n = 12), L3 (n = 10), L4 (n = 10) and L5 (n = 9). The demographic parameters of our cohort are shown in Table 1 . Table 1 Demographic characteristics. Gender Male 14 (29.2%) Female 34 (70.8%) Age , SD 70.9 ± 9.3 BMI (kg/m 2 ), SD 26.5 ± 4 T-Score , SD -1.9 ± 1.1 Vertebral fracture age 6 weeks 59 (54.6%) Vertebral segment treated Thoracic (T1 - T10) 42 (38.9%) Thoracolumbar (T11 – L2) 37 (34.3%) Lumbar (L3 – L5) 29 (26.8%) Type of fracture* Wedge 33 (30,6%) Biconcave 75 (69.4%) Severity of fracture* Grade I 39 (36.1%) Grade II 29 (26.9%) Grade III 40 (37%) IVVC No 85 (78.7%) Yes 23 (21.3%) Volume of cement injected 3.5 ± 1.18 BMI: Body Mass Index SD: Standard Deviation IVVC: Intervertebral vacuum cleft *According Genant classification 17 Description of the surgical technique Surgical treatment was performed under general anesthesia in prone position. We did not perform any maneuver to restore vertebral height before or during the procedure. Two imaging systems (SIEMENS Arcadis Orbic and SIEMENS Arcadis Varic) perpendicular to each other and centered on each vertebra were used. All vertebroplasties were performed through a bilateral transpedicular approach. Under fluoroscopic guidance, cement was injected. The cement injection continued until the vertebral body was filled toward the posterior 25% of the vertebral body or until leakage occurred. After cement injection, the patient remained prone on the table for approximately 20 minutes. The differences between using the StabiliT® MX System and PVP are: before injecting cement, a path is created with a flexible trocar, administration of cement is carried out with a remote control and cement viscosity is controlled by radiofrequency. The main benefit of this system is to try to reduce the volume of injected cement. Collected data All patients were studied pre-surgery, pre-cementation, post-cementation, at first medical check-up (6 weeks post-surgery) and at last medical check-up (minimum 6 months). Lateral X-ray was used to take the measurements. All images were taken at a distance of one meter from the patients ensuring that the upper and lower plate were properly aligned. In each vertebral body, anterior, middle (most collapsed zone and least collapsed zone) and posterior edge heights were measured (Fig. 1 ). Average vertebral height was measured and the difference calculated, in each period, from preoperative values. The posterior edge of one adjacent nonfractured vertebral body was also measured in each study period to validate the measurements. The first author made the measurements using a digital PACS caliper and he was blinded to clinical context in each case. Other assessed parameters were demographic data (age, gender, body mass index – BMI-, T-Score), vertebral fracture evolution time (less or more than 6 weeks), the type and severity of vertebral fracture according to the Genant classification 17 , IVVC presence, vertebral augmentation technique and volume of cement injected. The vertebral fracture location was classified as follows: thoracic (T1-T10), thoracolumbar (T11-L2) or lumbar (L3-L5). Statistical analysis of data Sample size was determined by two means, taking into account the data published in the article by Röllinghoff et al. 18 This study was chosen because the methodology was similar to our study. The mean and standard deviation of pre-surgical and post-surgical vertebral body height were chosen for vertebroplasty and StabiliT® system (vertebroplasty, 14.1 ± 5.1mm and 17.9 ± 4.2mm; StabiliT® system, 14.7 ± 5.6mm and 19.5 ± 4.5mm). Beta was 0.2 (80% power) and alpha (two-tailed) 0.05. We determined that a minimum of 24 vertebrae was needed if we took into account the results of PVP, or 18 vertebrae if we took into account the results of StabiliT® system. Descriptive statistics about the sample were obtained. The Shapiro-Wilk test confirmed normal distribution of the variables. Initially, a Pearson correlation coefficient was carried out between the demographic quantitative variables (age, BMI, T-Score) and the difference in overall height of the vertebral body at the different study timepoints regarding pre-surgical status. The gender variable was analyzed using Student’s T test at the different timepoints. Subsequently, we performed multiple linear regression to determine if vertebral fracture time, vertebral segment treated, type of fracture treated, severity of the fracture, IVVC presence or vertebral augmentation technique performed could influence the restoration or loss of vertebral height at each timepoint. Finally, to verify the validity of our model, we checked that the residuals followed a normal distribution. A 0.05 level of probability was accepted as criterion for statistical significance for all statistical tests. All statistical tests were carried out using Stata software 12.0 version for Macintosh (Data Analysis and Statistical Software, Texas, USA). Results Patients Average time from diagnosis to surgery was 60.4 ± 41.7 days. Specifically, 49 vertebrae (45.4%) were treated before the sixth week and 59 vertebrae (54.6%) were treated after the sixth week. Average age of patients was 70.9 ± 9.3-years. BMI was 26.5 ± 4kg/m 2 , and mean T-score was − 1.9 ± 1.1 (Table 1 ). Thoracic injury predominated, being found in 42 vertebrae (38.9%). According to the Genant classification 17 , 75 vertebral injuries were biconcave type (69.4%) and 33 vertebral injuries were wedge type (30.6%). A grade III collapse was the most frequent (Table 1 ). Average volume of injected cement was 3.5 ± 1.18ml. Radiological measurement. Pre-surgical radiography was performed 5.8 ± 3.6 days before the procedure. After surgery X-rays were performed at 46.5 ± 18.1 days (first medical check-up) and 17.1 ± 12 months post-surgery (last medical check-up). There were no differences, at each timepoint in the height of the posterior edge of one adjacent nonfractured vertebral body compared to the pre-surgical moment. (pre-surgery: 3.12 ± 0.04cm; pre-cementation: 3.11 ± 0.04cm, difference − 0.013 cm, P = 0.277; post-cementation: 3.1 ± 0.04cm, difference − 0.019cm, P = 0.264; first medical check-up: 3.1 ± 0.04cm, difference − 0.023, P = 0.079; last medical check-up: 3.12 ± 0.04cm, difference − 0.001cm, P = 0.911). Average pre-surgical vertebral body height was 2.2 ± 0.6 and increased to 2.3 ± 0.5 (difference with pre-surgical status of + 0.1 cm, + 4.5%, P = < 0.001) with the patient's position change on the surgical table (from standing to prone position). Post-cementation, vertebral body height increased to 2.5 ± 0.5 (difference with pre-surgical status of + 0.3 cm, + 13.6%, P = < 0.001). At the first medical check-up, vertebral body height increased to 2.3 ± 0.5 (difference with pre-surgical status of + 0.1 cm, + 4.5%, P = < 0.001). Finally, at the last medical check-up, vertebral body height had decreased to pre-surgical levels (2.2 ± 0,5 versus 2.2 ± 0,6, difference of + 0.009cm, + 0%, P = 0.7233) (Fig. 2 ). Multiple linear regression A Pearson correlation coefficient was performed between the quantitative demographic variables (age, BMI, T-Score) and the difference in vertebral body height at each timepoint with respect to the pre-surgical moment. No variable was statistically correlated (P = > 0.05) and they presented a weak association, so they were excluded from the multiple linear regression. The gender variable also had no statistical differences when the height difference of the vertebral body was compared at the different timepoints (P = > 0.05), and so this was also excluded from the multivariate analysis. We performed four multiple linear regression models, one for each timepoint (Table 2 ). As a dependent variable, the global difference in vertebral body height at the time of study analyzed with respect to the pre-surgical moment was used. The vertebral segment treated, type and severity of vertebral fracture, vertebral fracture time, vertebral augmentation technique and volume of cement injected were used as independent variables. Table 2 Multiple linear regression for the estimation of the overall vertebral body height at each timepoint with respect to the pre-surgical timepoint. Coefficient SD t P value 95% IC Pre-cementation model Vertebral segment treated Thoracic (T1-T10) Ref. Thoracolumbar (T11-L2) -0.03 0.05 -0.64 0.524 -0.14 to 0.72 Lumbar (L3-L5) 0.03 0.06 0.48 0.633 -0.08 to 0.14 Type of fracture Wedge Ref. Biconcave -0.02 0.051 -0.50 0.617 -0.13 to 0.08 Severity of fracture Grade I Ref. Grade II -0.023 0.057 -0.41 0.686 -0.13 to 0.09 Grade III 0.155 0.05 2.83 0.006 0.045 to 0.26 IVVC No Ref. Yes 0.06 0.05 1.16 0.250 -0.05 to 0.18 Vertebral fracture age 6 weeks -0.04 0.05 -0.78 0.438 -0.13 to 0.06 Constant 0.05 0.07 0.73 0.465 -0.09 to 0.20 Post-cementation model Vertebral segment treated Thoracic (T1-T10) Ref. Thoracolumbar (T11-L2) -0.13 0.07 -1.82 0.072 -0.27 to 0.01 Lumbar (L3-L5) 0.006 0.07 0.08 0.939 -0.14 to 0.16 Type of fracture Wedge Ref. Biconcave -0.03 0.07 -0.47 0.641 -0.17 to 0.11 Severity of fracture Grade I Ref. Grade II 0.007 0.07 0.1 0.921 -0.14 to 0.16 Grade III 0.18 0.07 2.4 0.018 0.03 to 0.32 IVVC No Ref. Yes 0.19 0.07 2.4 0.018 0.03 to 0.34 Vertebral fracture age 6 weeks 0.03 0.06 0.46 0.647 -0.095 to 0.15 Vertebral augmentation technique Vertebroplasty Ref. StabiliT system 0.13 0.08 1.66 0.1 -0.02 to 0.29 Cement injected 0.05 0.03 1.69 0.095 -0.01 to 0.1 Constant -0.03 0.12 -0.22 0.826 -0.26 to 0.21 First medical check-up model Vertebral segment treated Thoracic (T1-T10) Ref. Thoracolumbar (T11-L2) -0.14 0.06 -2.44 0.017 -0.26 to -0.03 Lumbar (L3-L5) -0.05 0.06 -0.74 0.464 -0.17 to 0.08 Type of fracture Wedge Ref. Biconcave -0.05 0.06 -0.93 0.354 -0.16 to 0.06 Severity of fracture Grade I Ref. Grade II -0.05 0.06 -0.88 0.379 -0.17 to 0.07 Grade III 0.15 0.06 2.57 0.012 0.03 to 0.27 IVVC No Ref. Yes 0.03 0.06 0.53 0.595 -0.09 to 0.16 Vertebral fracture age 6 weeks -0.04 0.05 -0.68 0.496 -0.13 to 0.06 Vertebral augmentation technique Vertebroplasty Ref. StabiliT system 0.22 0.06 3.46 0.001 0.09 to 0.35 Cement injected 0.0007 0.02 0.03 0.972 -0.04 to 0.04 Constant 0.12 0.09 1.23 0.221 -0.07 to 0.31 First medical check-up model Vertebral segment treated Thoracic (T1-T10) Ref. Thoracolumbar (T11-L2) -0.08 0.06 -1.36 0.176 -0.21 to 0.04 Lumbar (L3-L5) -0.06 0.07 -0.92 0.358 -0.19 to 0.07 Type of fracture Wedge Ref. Biconcave -0.06 0.06 -0.97 0.334 -0.18 to 0.07 Severity of fracture Grade I Ref. Grade II -0.08 0.07 -1.24 0.219 -0.21 to 0.05 Grade III 0.11 0.06 1.65 0.102 -0.02 to 0.23 IVVC No Ref. Yes 0.03 0.07 0.42 0.675 -0.11 to 0.16 Vertebral fracture age 6 weeks 0.06 0.05 1.08 0.283 -0.05 to 0.17 Vertebral augmentation technique Vertebroplasty Ref. StabiliT system 0.21 0.07 3.04 0.003 0.07 to 0.36 Cement injected -0.01 0.02 -0.44 0.66 -0.06 to 0.04 Constant 0.03 0.11 0.35 0.726 -0.17 to 0.24 SD: Standard deviation IVVC: Intervertebral vacuum cleft 95% IC: 95% confidence interval Grade I : 41%. All differences were statistically significant (P = < 0.001). The coefficient of determination squared was 0.1516 at pre-cementation moment, 0.2616 at post-cementation moment, 0.2585 at first medical check-up and 0.2263 at last medical check-up. The different linear regression models performed showed that the main factors influencing vertebral body height restoration were: grade III collapse (at pre-cementation time, post-cementation time and the first post-surgical medical check-up time), IVVC (only at the post-cementation time), and StabiliT ® system (at the first and last post-surgical medical check-up). In contrast, a fracture located in the thoracolumbar region negatively influenced vertebral body height (at the first post-surgical medical check-up) (Tables 2 and 3 ). Table 3 Factors related to the restoration of the vertebral body height at different timepoints. Increase height Reduce height Questionable Not associated Pre-cementation Collapse grade III Demographic factor (age, gender, BMI, T-Score) Vertebral segment treated Type of fracture IVVC Vertebral fracture age Post-cementation Collapse grade III IVVC Thoracolumbar zone Cement injected Demographic factor (age, gender, BMI, T-Score) Type of fracture IVVC Vertebral fracture age Vertebral augmentation technique First medical check-up Collapse grade III StabiliT system Thoracolumbar zone Demographic factor (age, gender, BMI, T-Score) Type of fracture IVVC Vertebral fracture age Cement injected Last medical check-up StabiliT system Demographic factor (age, gender, BMI, T-Score) Vertebral segment treated Type of fracture Severity of fracture IVVC Vertebral fracture age Cement injected Discussion This prospective study focuses on factors that influence restoration of the vertebral body height during vertebral fracture treatment, quantifying these from diagnosis to discharge. We observed that some factors favor the restoration of the vertebral body height while others affect it negatively. Furthermore, these factors act concretely at different times during patient follow-up. Previously published studies that analyze the change in vertebral body height after vertebral augmentation have various limitations 4 , 6 , 7 , 9 , 19 , 20 . Irregularity of the vertebral fracture makes it difficult to select a reference point to carry out the measurements, there is no consensus on how to quantify changes in vertebral body height and studies take into account different factors (dynamic mobility, IVVC, vertebral augmentation technique) that are analyzed in isolation and not as a whole 4 , 8 , 9 , 12 – 14 , 16 , 19 , 21 . This means that surgeons do not know at what point in patient follow-up these factors influence vertebral restoration. Overall changes in vertebral body have previously been studied at two points in time: pre- and post-surgery 4 – 6 , 12 , 18 . To provide more detailed and accurate information, we analyzed the vertebral body at different timepoints: pre-surgery, intra-operatively (pre-cementation and post-cementation), at first medical check-up (6 weeks) and at last medical check-up (17.1 ± 12 months). To our knowledge our study is the first to analyze changes intraoperatively, establishing the changes due to patient position in order to differentiate the real effect of vertebral augmentation 4,6,7,9−11 . Some authors 12 , 16 concluded that vertebral height restoration depends more on dynamic mobility than vertebral augmentation. McKiernan et al. 8 observed that approximately 35% of vertebrae were mobile. In our study, we found that after vertebral augmentation there was an increase in vertebral height of + 0.3cm (13.6%). Specifically, the patient's position change (standing to prone position) led to an increase in vertebral height of + 0.1 cm (+ 4.5%) and vertebral cementation caused a further increase in the vertebral body height of + 0.2cm (+ 8.7%). These findings go against the conclusion of Chen et al. 12 and Yokoyama et al. 16 , since mobility of the vertebra contributed to a third of the height restoration, and the cementation was the cause of the rest. If we assess, as a whole, the factors that influence vertebral height restoration, we can see that the factors act at different times. We observed that having a severe collapse (grade III) had the greatest influence when the patient was in the prone position (Tables 2 and 3 ). This observation differed from the conclusions of McKiernan et al. 8 or Teng et al. 9 who suggested that the change in height was favored by the presence of an IVVC. However, our results show that IVVC had the greatest influence when the vertebral augmentation was performed (P = 0.018) and not as a result of the patient's position change (P = 0.250). Determining to what extent and when a factor most influences vertebral height restoration is only possible if intraoperative radiographic measurements are performed. Thoracolumbar zone has greater mobility than thoracic or lumbar fractures 8 , 14 , 15 . However, they do not specify whether this factor favors or disfavors vertebral height restoration. Our results show that location in the thoracolumbar area negatively influenced vertebral height restoration (Tables 2 and 3 ) Tang et al. 21 and Takahashi et al. 22 suggested that vertebral fracture time evolution influences clinical and radiological results. Vertebral height and vertebral kyphotic angle after kyphoplasty were better in patients treated in the first two months from onset of symptoms. Based on our results, we cannot affirm that the time since vertebral fracture influenced in vertebral body height. Outcomes in our cohort should be interpreted with some caution due to the potential limitations of the study. We did not compare PVP with PKP. Literature shows that PKP requires more surgical time (which is harmful in elderly patients) and is more expensive, which is why several studies recommend using PVP over PKP 21 , 23 , 24 . Measurements were made with radiographs. We used this technique because it is easy to use, it can be performed intra-operatively and it allows us to study the vertebral body in different positions (standing and prone position). The gold-standard technique for making measurements is CT-scan. However, few hospitals can perform intraoperative CT-scan, and, in addition, it would mean exposing the patient to high doses of ionizing radiation. There may be other factors which influence the restoration of vertebral height that we have not collected. To understand factors involved in changes in the vertebral body height better, it would be interesting to make a comparison between a conservatively treated group and a surgical group. However, our present aim was to focus exclusively on vertebrae treated with vertebral augmentation. Conclusion Our study found that the patient’s position change (from standing to prone position) and vertebral augmentation produced an increase in the vertebral body height. After surgery there is a progressive collapse of the vertebral body that returns to pre-surgical values. The main factors that favor vertebral height restoration are: grade III collapse, IVVC, and vertebral augmentation technique. In contrast, a thoracolumbar location influenced vertebral height restoration negatively. Declarations ACKNOWLEDGEMENTS We thank Ruth Breeze for the language editing of the manuscript. AUTHOR CONTRIBUTIONS J.P., M.A designed the study. J.P, R.L and M.A carried out data collection. 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Osteoporotic vertebral compression fractures: surgery versus non-operative management. J Int Med Res 39 , 1438–1447. https://doi.org/10.1177/147323001103900432 (2011). Takahashi S, et al. Differences in short-term clinical and radiological outcomes depending on timing of balloon kyphoplasty for painful osteoporotic vertebral fracture. J Orthop Sci 23 , 51–56. https://doi.org/0.1016/j.jos.2017.09.019 (2018). Liu JT, et al. Balloon kyphoplasty versus vertebroplasty for treatment of osteoporotic vertebral compression fracture: A prospective, comparative, and randomized clinical study. Osteoporos Int 21 , 359–364. https://doi.org/10.1007/s00198-009-0952-8 (2010). Chang X, et al. Vertebroplasty versus kyphoplasty in osteoporotic vertebral compression fracture: a meta-analysis of prospective comparative studies. Int Orthop 39 , 491–500. https://doi.org/10.1007/s00264-014-2525-5 (2015). Additional Declarations No competing interests reported. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-430234","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":22317869,"identity":"df3abe8b-8697-4820-a798-12e93920586e","order_by":0,"name":"Jesús Payo-Ollero","email":"","orcid":"","institution":"University of Navarra","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jesús","middleName":"","lastName":"Payo-Ollero","suffix":""},{"id":22317870,"identity":"6b9e9adb-34ba-4909-88c4-8d2eb6712821","order_by":1,"name":"Rafael Llombart-Blanco","email":"","orcid":"","institution":"University of Navarra","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Rafael","middleName":"","lastName":"Llombart-Blanco","suffix":""},{"id":22317871,"identity":"934f7265-5de2-4bb1-8f96-35258a9784aa","order_by":2,"name":"Carlos Villas","email":"","orcid":"","institution":"University of Navarra","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Carlos","middleName":"","lastName":"Villas","suffix":""},{"id":22317872,"identity":"07b191ec-5e31-4eed-8730-9dc76e847c37","order_by":3,"name":"Matías Alfonso","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAzElEQVRIiWNgGAWjYFAC5oYPYJqd+QCxWhgbZ0C0siWQrIXHgDgNuu0HGxs+7qiT42fm+SZdUHOYgZ+fgAPNziQ2Ns48c9hYspl3m/SMY4cZJGcQcKDZgcT2x7xtBxI3HAZq4WFLYzC4QcBhZucfNjbzttUBtfA8k+b5l8Zgf56Qw24kgrQwg7SwSfO22TAYMBBy2I2HQL+0gfzCZmzN22fDI3GDkJbzyQcbPrYBQ4y9+eFtnm8Scvz9BByGAXhIVD8KRsEoGAWjABsAAMhJQcLQP4kiAAAAAElFTkSuQmCC","orcid":"","institution":"University of Navarra","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Matías","middleName":"","lastName":"Alfonso","suffix":""}],"badges":[],"createdAt":"2021-04-16 19:14:08","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-430234/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-430234/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":8304089,"identity":"1ac2ab0e-b8d9-45c8-b178-9bc75d70f358","added_by":"auto","created_at":"2021-04-21 21:56:25","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":272235,"visible":true,"origin":"","legend":"Lateral X-ray showing the measurements performed in the anterior, middle (most collapsed zone and least collapsed zone) and posterior edge. ","description":"","filename":"Figure1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-430234/v1/28531c9a83a3449e1c1def15.jpg"},{"id":8303932,"identity":"77a82a8c-af86-462c-8850-372e81341ae3","added_by":"auto","created_at":"2021-04-21 21:53:25","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":360750,"visible":true,"origin":"","legend":"Changes in vertebral body height during follow-up. First medical check-up at 46.5±18.1 days from surgery. Last medical check-up at 17.1±12 months from surgery. ","description":"","filename":"Figure2.jpg","url":"https://assets-eu.researchsquare.com/files/rs-430234/v1/43db0c454f23cfae23d0dcea.jpg"},{"id":17367854,"identity":"efd1de8d-f994-4f08-9bd0-d67d7d134d33","added_by":"auto","created_at":"2022-01-17 06:44:20","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":765195,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-430234/v1/d415c214-a75b-40fc-a2f6-40f6d79b4bc1.pdf"},{"id":8303825,"identity":"a5d98269-5fb5-4823-a350-f5ad423b6892","added_by":"auto","created_at":"2021-04-21 21:50:24","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":15888,"visible":true,"origin":"","legend":"","description":"","filename":"Table1.docx","url":"https://assets-eu.researchsquare.com/files/rs-430234/v1/de232d3b1f7d035cdf1896b4.docx"},{"id":8303933,"identity":"f30e385e-50af-43e9-a192-357fd9846976","added_by":"auto","created_at":"2021-04-21 21:53:25","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":16374,"visible":true,"origin":"","legend":"","description":"","filename":"Table3.docx","url":"https://assets-eu.researchsquare.com/files/rs-430234/v1/51942ca40fdaa11ba6fb09b9.docx"},{"id":8303826,"identity":"a5ba0722-662a-4427-af18-53f2414e991f","added_by":"auto","created_at":"2021-04-21 21:50:25","extension":"docx","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":24940,"visible":true,"origin":"","legend":"","description":"","filename":"Table2.docx","url":"https://assets-eu.researchsquare.com/files/rs-430234/v1/7a374e2a4e326259cc7f8be2.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"Vertebral body height changes in acute symptomatic osteoporotic vertebral compression fractures treated with vertebral cement augmentation. Which factors affect vertebral body height?","fulltext":[{"header":"Introduction","content":" \u003cp\u003eDifferent meta-analyzes compared percutaneous vertebroplasty (PVP) with conservative treatment for osteoporotic vertebral compression fractures (OVCFs), reaching the conclusion that PVP achieves greater pain relief, greater functional recovery and better quality of life during the first post-operative year\u003csup\u003e\u003cspan additionalcitationids=\"CR2\" citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eAlthough vertebral height restoration is not an objective of PVP, numerous studies showed that there is an increase in vertebral body height after PVP of 1.2-2.3mm\u003csup\u003e\u003cspan additionalcitationids=\"CR5 CR6 CR7 CR8\" citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e\u003c/sup\u003e. However, increase in vertebral body height is frequently calculated comparing pre and postsurgical measurements, which means that changes because of the patient's position (standing to prone position) are not taken into account, and could bias the vertebral augmentation effect\u003csup\u003e4,7,9\u0026minus;11\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eIncrease in vertebral body height depends on different factors. Dynamic mobility, conditioned by the patient\u0026rsquo;s position, is the change in the vertebral body height when the patient goes from standing to supine or prone position, and constitutes one of the most important factors\u003csup\u003e8,12\u0026minus;16\u003c/sup\u003e. The type of vertebral fracture (wedge, biconcave or burst) determines which area of ​​the vertebral body (anterior, middle, or posterior) experiences greater mobility\u003csup\u003e\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e,\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e,\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e\u003c/sup\u003e. Vertebral fractures of the thoracolumbar region have greater mobility than those in the thoracic region or lumbar region\u003csup\u003e\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e,\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e\u003c/sup\u003e. Percutaneous kyphoplasty (PKP) achieves greater restoration of vertebral height than PVP\u003csup\u003e\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e,\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e\u003c/sup\u003e. The presence of intervertebral vacuum cleft (IVVC) is another important factor\u003csup\u003e\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e,\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e\u003c/sup\u003e, and these clefts are usually located in the thoracolumbar region. All these factors are generally analyzed in isolation and not as a whole, so the surgeon does not really know when these factors may exert an influence during patient follow-up. The aim of this study is to specify the factors influencing restoration of vertebral body height after PVP, from the vertebral body fracture until the patient is definitively discharged.\u003c/p\u003e "},{"header":"Materials And Methods","content":" \u003cp\u003eApproval for this prospective study was given by the Regional Ethical Review Board at our institution (University of Navarra, reference code, 2018.044). Before participating, all patients gave written consent to participate in this study after having received oral and written information. In addition, the study was conducted in accordance with the 1975 Helsinky Declaration, revised in 2013.\u003c/p\u003e \u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003ePatient selection\u003c/h2\u003e \u003cp\u003eOur cohort consisted of patients who had been treated for acute painful OVCFs and who met the inclusion criteria over the period February 2015 to February 2020. Recruitment criteria were: acute painful OVCFs, failure of conservative treatment (non-steroidal anti-inflammatory drugs, soft orthosis and lumbar exercises), progressive collapse of the vertebral body, reproducible pain at the level of the fractured vertebra, with either current MRI showing bone edema on the STIR sequence or cement augmentation without instrumentation. The patients were excluded if they did not meet inclusion criteria, if they had a vertebral fracture secondary to oncological disease, or if cement augmentation was associated with instrumentation. Of 50 patients (117 vertebrae) treated with cement augmentation, 2 (9 vertebrae) were excluded because they were lost to follow-up. Finally, 48 patients (108 vertebrae) were included. Eighty-eight vertebrae were treated with percutaneous vertebroplasty (DePuy Synthes, Oberdorf, Switzerland) and twenty vertebrae were treated with a flexible trocar StabiliT\u0026reg; MX System (DFine, San Jos\u0026eacute;, USA). All patients underwent conventional AP/Lateral X-Rays as well as MRI pre-surgery. The location of the treated vertebrae was as follows: T5 (n\u0026thinsp;=\u0026thinsp;2), T6 (n\u0026thinsp;=\u0026thinsp;9), T7 (n\u0026thinsp;=\u0026thinsp;9), T8 (n\u0026thinsp;=\u0026thinsp;10), T9 (n\u0026thinsp;=\u0026thinsp;6), T10 (n\u0026thinsp;=\u0026thinsp;6), T11 (n\u0026thinsp;=\u0026thinsp;5), T12 (n\u0026thinsp;=\u0026thinsp;10), L1 (n\u0026thinsp;=\u0026thinsp;10), L2 (n\u0026thinsp;=\u0026thinsp;12), L3 (n\u0026thinsp;=\u0026thinsp;10), L4 (n\u0026thinsp;=\u0026thinsp;10) and L5 (n\u0026thinsp;=\u0026thinsp;9). The demographic parameters of our cohort are shown in Table\u0026nbsp;\u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e1\u003c/span\u003e.\u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab1\" border=\"1\"\u003e \u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 1\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eDemographic characteristics.\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e \u003ccolgroup cols=\"2\"\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colname=\"c1\"\u003e \u003cp\u003eGender\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eMale\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e14 (29.2%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eFemale\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e34 (70.8%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eAge\u003c/b\u003e, SD\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e70.9\u0026thinsp;\u0026plusmn;\u0026thinsp;9.3\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eBMI\u003c/b\u003e (kg/m\u003csup\u003e2\u003c/sup\u003e), SD\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e26.5\u0026thinsp;\u0026plusmn;\u0026thinsp;4\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eT-Score\u003c/b\u003e, SD\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-1.9\u0026thinsp;\u0026plusmn;\u0026thinsp;1.1\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eVertebral fracture age\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u0026lt;\u0026thinsp;6 weeks\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e49 (45.5%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u0026gt;\u0026thinsp;6 weeks\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e59 (54.6%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eVertebral segment treated\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eThoracic (T1 - T10)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e42 (38.9%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eThoracolumbar (T11 \u0026ndash; L2)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e37 (34.3%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eLumbar (L3 \u0026ndash; L5)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e29 (26.8%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eType of fracture*\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eWedge\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e33 (30,6%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eBiconcave\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e75 (69.4%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eSeverity of fracture*\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eGrade I\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e39 (36.1%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eGrade II\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e29 (26.9%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eGrade III\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e40 (37%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eIVVC\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eNo\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e85 (78.7%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003eYes\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e23 (21.3%)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eVolume of cement injected\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e3.5\u0026thinsp;\u0026plusmn;\u0026thinsp;1.18\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003eBMI: Body Mass Index\u003c/p\u003e \u003cp\u003eSD: Standard Deviation\u003c/p\u003e \u003cp\u003eIVVC: Intervertebral vacuum cleft\u003c/p\u003e \u003cp\u003e*According Genant classification\u003csup\u003e\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec4\" class=\"Section2\"\u003e \u003ch2\u003eDescription of the surgical technique\u003c/h2\u003e \u003cp\u003eSurgical treatment was performed under general anesthesia in prone position. We did not perform any maneuver to restore vertebral height before or during the procedure. Two imaging systems (SIEMENS Arcadis Orbic and SIEMENS Arcadis Varic) perpendicular to each other and centered on each vertebra were used. All vertebroplasties were performed through a bilateral transpedicular approach. Under fluoroscopic guidance, cement was injected. The cement injection continued until the vertebral body was filled toward the posterior 25% of the vertebral body or until leakage occurred. After cement injection, the patient remained prone on the table for approximately 20 minutes.\u003c/p\u003e \u003cp\u003eThe differences between using the StabiliT\u0026reg; MX System and PVP are: before injecting cement, a path is created with a flexible trocar, administration of cement is carried out with a remote control and cement viscosity is controlled by radiofrequency. The main benefit of this system is to try to reduce the volume of injected cement.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec5\" class=\"Section2\"\u003e \u003ch2\u003eCollected data\u003c/h2\u003e \u003cp\u003eAll patients were studied pre-surgery, pre-cementation, post-cementation, at first medical check-up (6 weeks post-surgery) and at last medical check-up (minimum 6 months). Lateral X-ray was used to take the measurements. All images were taken at a distance of one meter from the patients ensuring that the upper and lower plate were properly aligned. In each vertebral body, anterior, middle (most collapsed zone and least collapsed zone) and posterior edge heights were measured (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e). Average vertebral height was measured and the difference calculated, in each period, from preoperative values. The posterior edge of one adjacent nonfractured vertebral body was also measured in each study period to validate the measurements. The first author made the measurements using a digital PACS caliper and he was blinded to clinical context in each case.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003eOther assessed parameters were demographic data (age, gender, body mass index \u0026ndash; BMI-, T-Score), vertebral fracture evolution time (less or more than 6 weeks), the type and severity of vertebral fracture according to the Genant classification\u003csup\u003e\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e\u003c/sup\u003e, IVVC presence, vertebral augmentation technique and volume of cement injected. The vertebral fracture location was classified as follows: thoracic (T1-T10), thoracolumbar (T11-L2) or lumbar (L3-L5).\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec6\" class=\"Section2\"\u003e \u003ch2\u003eStatistical analysis of data\u003c/h2\u003e \u003cp\u003eSample size was determined by two means, taking into account the data published in the article by R\u0026ouml;llinghoff et al.\u003csup\u003e\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e\u003c/sup\u003e This study was chosen because the methodology was similar to our study. The mean and standard deviation of pre-surgical and post-surgical vertebral body height were chosen for vertebroplasty and StabiliT\u0026reg; system (vertebroplasty, 14.1\u0026thinsp;\u0026plusmn;\u0026thinsp;5.1mm and 17.9\u0026thinsp;\u0026plusmn;\u0026thinsp;4.2mm; StabiliT\u0026reg; system, 14.7\u0026thinsp;\u0026plusmn;\u0026thinsp;5.6mm and 19.5\u0026thinsp;\u0026plusmn;\u0026thinsp;4.5mm). Beta was 0.2 (80% power) and alpha (two-tailed) 0.05. We determined that a minimum of 24 vertebrae was needed if we took into account the results of PVP, or 18 vertebrae if we took into account the results of StabiliT\u0026reg; system.\u003c/p\u003e \u003cp\u003eDescriptive statistics about the sample were obtained. The Shapiro-Wilk test confirmed normal distribution of the variables. Initially, a Pearson correlation coefficient was carried out between the demographic quantitative variables (age, BMI, T-Score) and the difference in overall height of the vertebral body at the different study timepoints regarding pre-surgical status. The gender variable was analyzed using Student\u0026rsquo;s T test at the different timepoints.\u003c/p\u003e \u003cp\u003eSubsequently, we performed multiple linear regression to determine if vertebral fracture time, vertebral segment treated, type of fracture treated, severity of the fracture, IVVC presence or vertebral augmentation technique performed could influence the restoration or loss of vertebral height at each timepoint. Finally, to verify the validity of our model, we checked that the residuals followed a normal distribution.\u003c/p\u003e \u003cp\u003eA 0.05 level of probability was accepted as criterion for statistical significance for all statistical tests. All statistical tests were carried out using Stata software 12.0 version for Macintosh (Data Analysis and Statistical Software, Texas, USA).\u003c/p\u003e \u003c/div\u003e "},{"header":"Results","content":" \u003cdiv id=\"Sec8\" class=\"Section2\"\u003e \u003ch2\u003ePatients\u003c/h2\u003e \u003cp\u003eAverage time from diagnosis to surgery was 60.4\u0026thinsp;\u0026plusmn;\u0026thinsp;41.7 days. Specifically, 49 vertebrae (45.4%) were treated before the sixth week and 59 vertebrae (54.6%) were treated after the sixth week. Average age of patients was 70.9\u0026thinsp;\u0026plusmn;\u0026thinsp;9.3-years. BMI was 26.5\u0026thinsp;\u0026plusmn;\u0026thinsp;4kg/m\u003csup\u003e2\u003c/sup\u003e, and mean T-score was \u0026minus;\u0026thinsp;1.9\u0026thinsp;\u0026plusmn;\u0026thinsp;1.1 (Table\u0026nbsp;\u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e1\u003c/span\u003e). Thoracic injury predominated, being found in 42 vertebrae (38.9%). According to the Genant classification\u003csup\u003e\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e\u003c/sup\u003e, 75 vertebral injuries were biconcave type (69.4%) and 33 vertebral injuries were wedge type (30.6%). A grade III collapse was the most frequent (Table\u0026nbsp;\u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e1\u003c/span\u003e). Average volume of injected cement was 3.5\u0026thinsp;\u0026plusmn;\u0026thinsp;1.18ml.\u003c/p\u003e \u003cp\u003e \u003cb\u003eRadiological measurement.\u003c/b\u003e \u003c/p\u003e \u003cp\u003ePre-surgical radiography was performed 5.8\u0026thinsp;\u0026plusmn;\u0026thinsp;3.6 days before the procedure. After surgery X-rays were performed at 46.5\u0026thinsp;\u0026plusmn;\u0026thinsp;18.1 days (first medical check-up) and 17.1\u0026thinsp;\u0026plusmn;\u0026thinsp;12 months post-surgery (last medical check-up).\u003c/p\u003e \u003cp\u003eThere were no differences, at each timepoint in the height of the posterior edge of one adjacent nonfractured vertebral body compared to the pre-surgical moment. (pre-surgery: 3.12\u0026thinsp;\u0026plusmn;\u0026thinsp;0.04cm; pre-cementation: 3.11\u0026thinsp;\u0026plusmn;\u0026thinsp;0.04cm, difference \u0026minus;\u0026thinsp;0.013 cm, P\u0026thinsp;=\u0026thinsp;0.277; post-cementation: 3.1\u0026thinsp;\u0026plusmn;\u0026thinsp;0.04cm, difference \u0026minus;\u0026thinsp;0.019cm, P\u0026thinsp;=\u0026thinsp;0.264; first medical check-up: 3.1\u0026thinsp;\u0026plusmn;\u0026thinsp;0.04cm, difference \u0026minus;\u0026thinsp;0.023, P\u0026thinsp;=\u0026thinsp;0.079; last medical check-up: 3.12\u0026thinsp;\u0026plusmn;\u0026thinsp;0.04cm, difference \u0026minus;\u0026thinsp;0.001cm, P\u0026thinsp;=\u0026thinsp;0.911).\u003c/p\u003e \u003cp\u003eAverage pre-surgical vertebral body height was 2.2\u0026thinsp;\u0026plusmn;\u0026thinsp;0.6 and increased to 2.3\u0026thinsp;\u0026plusmn;\u0026thinsp;0.5 (difference with pre-surgical status of +\u0026thinsp;0.1 cm, +\u0026thinsp;4.5%, P\u0026thinsp;=\u0026thinsp;\u0026lt;\u0026thinsp;0.001) with the patient's position change on the surgical table (from standing to prone position). Post-cementation, vertebral body height increased to 2.5\u0026thinsp;\u0026plusmn;\u0026thinsp;0.5 (difference with pre-surgical status of +\u0026thinsp;0.3 cm, +\u0026thinsp;13.6%, P\u0026thinsp;=\u0026thinsp;\u0026lt;\u0026thinsp;0.001). At the first medical check-up, vertebral body height increased to 2.3\u0026thinsp;\u0026plusmn;\u0026thinsp;0.5 (difference with pre-surgical status of +\u0026thinsp;0.1 cm, +\u0026thinsp;4.5%, P\u0026thinsp;=\u0026thinsp;\u0026lt;\u0026thinsp;0.001). Finally, at the last medical check-up, vertebral body height had decreased to pre-surgical levels (2.2\u0026thinsp;\u0026plusmn;\u0026thinsp;0,5 versus 2.2\u0026thinsp;\u0026plusmn;\u0026thinsp;0,6, difference of +\u0026thinsp;0.009cm, +\u0026thinsp;0%, P\u0026thinsp;=\u0026thinsp;0.7233) (Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003e).\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec9\" class=\"Section2\"\u003e \u003ch2\u003eMultiple linear regression\u003c/h2\u003e \u003cp\u003eA Pearson correlation coefficient was performed between the quantitative demographic variables (age, BMI, T-Score) and the difference in vertebral body height at each timepoint with respect to the pre-surgical moment. No variable was statistically correlated (P\u0026thinsp;=\u0026thinsp;\u0026gt;\u0026thinsp;0.05) and they presented a weak association, so they were excluded from the multiple linear regression. The gender variable also had no statistical differences when the height difference of the vertebral body was compared at the different timepoints (P\u0026thinsp;=\u0026thinsp;\u0026gt;\u0026thinsp;0.05), and so this was also excluded from the multivariate analysis.\u003c/p\u003e \u003cp\u003eWe performed four multiple linear regression models, one for each timepoint (Table\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e2\u003c/span\u003e). As a dependent variable, the global difference in vertebral body height at the time of study analyzed with respect to the pre-surgical moment was used. The vertebral segment treated, type and severity of vertebral fracture, vertebral fracture time, vertebral augmentation technique and volume of cement injected were used as independent variables.\u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab2\" border=\"1\"\u003e \u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 2\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003e Multiple linear regression for the estimation of the overall vertebral body height at each timepoint with respect to the pre-surgical timepoint.\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e \u003ccolgroup cols=\"6\"\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e \u003cth align=\"left\" colname=\"c2\"\u003e \u003cp\u003eCoefficient\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003eSD\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003et\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003eP value\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c6\"\u003e \u003cp\u003e95% IC\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003ePre-cementation model\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eVertebral segment treated\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eThoracic (T1-T10)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eThoracolumbar (T11-L2)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-0.03\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.05\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e-0.64\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.524\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.14 to 0.72\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eLumbar (L3-L5)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.03\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0.48\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.633\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.08 to 0.14\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eType of fracture\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eWedge\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eBiconcave\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-0.02\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.051\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e-0.50\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.617\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.13 to 0.08\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eSeverity of fracture\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eGrade I\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eGrade II\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-0.023\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.057\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e-0.41\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.686\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.13 to 0.09\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eGrade III\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.155\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.05\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e2.83\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e0.006\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.045 to 0.26\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eIVVC\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eNo\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eYes\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.05\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e1.16\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.250\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.05 to 0.18\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eVertebral fracture age\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;6 weeks\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003e\u0026gt;\u0026thinsp;6 weeks\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-0.04\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.05\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e-0.78\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.438\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.13 to 0.06\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eConstant\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.05\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.07\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0.73\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.465\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.09 to 0.20\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003ePost-cementation model\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eVertebral segment treated\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eThoracic (T1-T10)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eThoracolumbar (T11-L2)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-0.13\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.07\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e-1.82\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.072\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.27 to 0.01\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eLumbar (L3-L5)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.006\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.07\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0.08\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.939\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.14 to 0.16\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eType of fracture\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eWedge\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eBiconcave\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-0.03\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.07\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e-0.47\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.641\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.17 to 0.11\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eSeverity of fracture\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eGrade I\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eGrade II\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.007\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.07\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0.1\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.921\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.14 to 0.16\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eGrade III\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.18\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.07\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e2.4\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e0.018\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.03 to 0.32\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eIVVC\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eNo\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eYes\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.19\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.07\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e2.4\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e0.018\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.03 to 0.34\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eVertebral fracture age\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;6 weeks\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003e\u0026gt;\u0026thinsp;6 weeks\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.03\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0.46\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.647\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.095 to 0.15\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eVertebral augmentation technique\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eVertebroplasty\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eStabiliT system\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.13\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.08\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e1.66\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.1\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.02 to 0.29\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eCement injected\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.05\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.03\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e1.69\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.095\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.01 to 0.1\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eConstant\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-0.03\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.12\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e-0.22\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.826\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.26 to 0.21\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eFirst medical check-up model\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eVertebral segment treated\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eThoracic (T1-T10)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eThoracolumbar (T11-L2)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-0.14\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e-2.44\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e0.017\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.26 to -0.03\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eLumbar (L3-L5)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-0.05\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e-0.74\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.464\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.17 to 0.08\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eType of fracture\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eWedge\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eBiconcave\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-0.05\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e-0.93\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.354\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.16 to 0.06\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eSeverity of fracture\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eGrade I\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eGrade II\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-0.05\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e-0.88\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.379\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.17 to 0.07\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eGrade III\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.15\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e2.57\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e0.012\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.03 to 0.27\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eIVVC\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eNo\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eYes\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.03\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0.53\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.595\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.09 to 0.16\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eVertebral fracture age\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;6 weeks\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003e\u0026gt;\u0026thinsp;6 weeks\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-0.04\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.05\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e-0.68\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.496\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.13 to 0.06\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eVertebral augmentation technique\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eVertebroplasty\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eStabiliT system\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.22\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e3.46\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e0.001\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.09 to 0.35\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eCement injected\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.0007\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.02\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0.03\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.972\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.04 to 0.04\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eConstant\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.12\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.09\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e1.23\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.221\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.07 to 0.31\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eFirst medical check-up model\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eVertebral segment treated\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eThoracic (T1-T10)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eThoracolumbar (T11-L2)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-0.08\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e-1.36\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.176\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.21 to 0.04\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eLumbar (L3-L5)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-0.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.07\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e-0.92\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.358\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.19 to 0.07\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eType of fracture\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eWedge\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eBiconcave\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-0.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e-0.97\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.334\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.18 to 0.07\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eSeverity of fracture\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eGrade I\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eGrade II\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-0.08\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.07\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e-1.24\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.219\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.21 to 0.05\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eGrade III\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.11\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e1.65\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.102\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.02 to 0.23\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eIVVC\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eNo\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eYes\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.03\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.07\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0.42\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.675\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.11 to 0.16\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eVertebral fracture age\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003e\u0026lt;\u0026thinsp;6 weeks\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003e\u0026gt;\u0026thinsp;6 weeks\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.05\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e1.08\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.283\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.05 to 0.17\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eVertebral augmentation technique\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eVertebroplasty\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cem\u003eRef.\u003c/em\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eStabiliT system\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.21\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.07\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e3.04\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003e0.003\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.07 to 0.36\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eCement injected\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e-0.01\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.02\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e-0.44\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.66\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.06 to 0.04\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eConstant\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e0.03\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e0.11\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e0.35\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e0.726\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e-0.17 to 0.24\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003eSD: Standard deviation\u003c/p\u003e \u003cp\u003eIVVC: Intervertebral vacuum cleft\u003c/p\u003e \u003cp\u003e95% IC: 95% confidence interval\u003c/p\u003e \u003cp\u003e\u003cb\u003eGrade I\u003c/b\u003e: \u0026lt;25%; \u003cb\u003eGrade II\u003c/b\u003e: 26\u0026ndash;40%. \u003cb\u003eGrade III\u003c/b\u003e: \u0026gt;41%.\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e \u003cp\u003eAll differences were statistically significant (P\u0026thinsp;=\u0026thinsp;\u0026lt;\u0026thinsp;0.001). The coefficient of determination squared was 0.1516 at pre-cementation moment, 0.2616 at post-cementation moment, 0.2585 at first medical check-up and 0.2263 at last medical check-up. The different linear regression models performed showed that the main factors influencing vertebral body height restoration were: grade III collapse (at pre-cementation time, post-cementation time and the first post-surgical medical check-up time), IVVC (only at the post-cementation time), and StabiliT\u003csup\u003e\u0026reg;\u003c/sup\u003e system (at the first and last post-surgical medical check-up). In contrast, a fracture located in the thoracolumbar region negatively influenced vertebral body height (at the first post-surgical medical check-up) (Tables\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e2\u003c/span\u003e and \u003cspan refid=\"Tab3\" class=\"InternalRef\"\u003e3\u003c/span\u003e).\u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab3\" border=\"1\"\u003e \u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 3\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eFactors related to the restoration of the vertebral body height at different timepoints.\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e \u003ccolgroup cols=\"5\"\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e \u003cth align=\"left\" colname=\"c2\"\u003e \u003cp\u003eIncrease height\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003eReduce height\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003eQuestionable\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003eNot associated\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003ePre-cementation\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eCollapse grade III\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003eDemographic factor (age, gender, BMI, T-Score)\u003c/p\u003e \u003cp\u003eVertebral segment treated\u003c/p\u003e \u003cp\u003eType of fracture\u003c/p\u003e \u003cp\u003eIVVC\u003c/p\u003e \u003cp\u003eVertebral fracture age\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003ePost-cementation\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eCollapse grade III\u003c/p\u003e \u003cp\u003eIVVC\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003eThoracolumbar zone\u003c/p\u003e \u003cp\u003eCement injected\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003eDemographic factor (age, gender, BMI, T-Score)\u003c/p\u003e \u003cp\u003eType of fracture\u003c/p\u003e \u003cp\u003eIVVC\u003c/p\u003e \u003cp\u003eVertebral fracture age\u003c/p\u003e \u003cp\u003eVertebral augmentation technique\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eFirst medical check-up\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eCollapse grade III\u003c/p\u003e \u003cp\u003eStabiliT system\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003eThoracolumbar zone\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003eDemographic factor (age, gender, BMI, T-Score)\u003c/p\u003e \u003cp\u003eType of fracture\u003c/p\u003e \u003cp\u003eIVVC\u003c/p\u003e \u003cp\u003eVertebral fracture age\u003c/p\u003e \u003cp\u003eCement injected\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\"\u003e \u003cp\u003e\u003cb\u003eLast medical check-up\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eStabiliT system\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003eDemographic factor (age, gender, BMI, T-Score)\u003c/p\u003e \u003cp\u003eVertebral segment treated\u003c/p\u003e \u003cp\u003eType of fracture\u003c/p\u003e \u003cp\u003eSeverity of fracture\u003c/p\u003e \u003cp\u003eIVVC\u003c/p\u003e \u003cp\u003eVertebral fracture age\u003c/p\u003e \u003cp\u003eCement injected\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e \u003c/div\u003e "},{"header":"Discussion","content":" \u003cp\u003eThis prospective study focuses on factors that influence restoration of the vertebral body height during vertebral fracture treatment, quantifying these from diagnosis to discharge. We observed that some factors favor the restoration of the vertebral body height while others affect it negatively. Furthermore, these factors act concretely at different times during patient follow-up.\u003c/p\u003e \u003cp\u003ePreviously published studies that analyze the change in vertebral body height after vertebral augmentation have various limitations\u003csup\u003e\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e,\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e,\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e,\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e,\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e,\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e\u003c/sup\u003e. Irregularity of the vertebral fracture makes it difficult to select a reference point to carry out the measurements, there is no consensus on how to quantify changes in vertebral body height and studies take into account different factors (dynamic mobility, IVVC, vertebral augmentation technique) that are analyzed in isolation and not as a whole\u003csup\u003e\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e,\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e,\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan additionalcitationids=\"CR13\" citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e,\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e,\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e,\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e\u003c/sup\u003e. This means that surgeons do not know at what point in patient follow-up these factors influence vertebral restoration.\u003c/p\u003e \u003cp\u003eOverall changes in vertebral body have previously been studied at two points in time: pre- and post-surgery\u003csup\u003e\u003cspan additionalcitationids=\"CR5\" citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e, \u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e,\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e\u003c/sup\u003e. To provide more detailed and accurate information, we analyzed the vertebral body at different timepoints: pre-surgery, intra-operatively (pre-cementation and post-cementation), at first medical check-up (6 weeks) and at last medical check-up (17.1\u0026thinsp;\u0026plusmn;\u0026thinsp;12 months). To our knowledge our study is the first to analyze changes intraoperatively, establishing the changes due to patient position in order to differentiate the real effect of vertebral augmentation\u003csup\u003e4,6,7,9\u0026minus;11\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eSome authors\u003csup\u003e\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e,\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e\u003c/sup\u003e concluded that vertebral height restoration depends more on dynamic mobility than vertebral augmentation. McKiernan et al.\u003csup\u003e\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e\u003c/sup\u003e observed that approximately 35% of vertebrae were mobile. In our study, we found that after vertebral augmentation there was an increase in vertebral height of +\u0026thinsp;0.3cm (13.6%). Specifically, the patient's position change (standing to prone position) led to an increase in vertebral height of +\u0026thinsp;0.1 cm (+\u0026thinsp;4.5%) and vertebral cementation caused a further increase in the vertebral body height of +\u0026thinsp;0.2cm (+\u0026thinsp;8.7%). These findings go against the conclusion of Chen et al.\u003csup\u003e\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e\u003c/sup\u003e and Yokoyama et al.\u003csup\u003e\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e\u003c/sup\u003e, since mobility of the vertebra contributed to a third of the height restoration, and the cementation was the cause of the rest.\u003c/p\u003e \u003cp\u003eIf we assess, as a whole, the factors that influence vertebral height restoration, we can see that the factors act at different times. We observed that having a severe collapse (grade III) had the greatest influence when the patient was in the prone position (Tables\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e2\u003c/span\u003e and \u003cspan refid=\"Tab3\" class=\"InternalRef\"\u003e3\u003c/span\u003e). This observation differed from the conclusions of McKiernan et al.\u003csup\u003e\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e\u003c/sup\u003e or Teng et al.\u003csup\u003e\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e\u003c/sup\u003e who suggested that the change in height was favored by the presence of an IVVC. However, our results show that IVVC had the greatest influence when the vertebral augmentation was performed (P\u0026thinsp;=\u0026thinsp;0.018) and not as a result of the patient's position change (P\u0026thinsp;=\u0026thinsp;0.250). Determining to what extent and when a factor most influences vertebral height restoration is only possible if intraoperative radiographic measurements are performed.\u003c/p\u003e \u003cp\u003eThoracolumbar zone has greater mobility than thoracic or lumbar fractures\u003csup\u003e\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e,\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e,\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e\u003c/sup\u003e. However, they do not specify whether this factor favors or disfavors vertebral height restoration. Our results show that location in the thoracolumbar area negatively influenced vertebral height restoration (Tables\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e2\u003c/span\u003e and \u003cspan refid=\"Tab3\" class=\"InternalRef\"\u003e3\u003c/span\u003e)\u003c/p\u003e \u003cp\u003eTang et al.\u003csup\u003e\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e\u003c/sup\u003e and Takahashi et al.\u003csup\u003e\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e\u003c/sup\u003e suggested that vertebral fracture time evolution influences clinical and radiological results. Vertebral height and vertebral kyphotic angle after kyphoplasty were better in patients treated in the first two months from onset of symptoms. Based on our results, we cannot affirm that the time since vertebral fracture influenced in vertebral body height.\u003c/p\u003e \u003cp\u003eOutcomes in our cohort should be interpreted with some caution due to the potential limitations of the study. We did not compare PVP with PKP. Literature shows that PKP requires more surgical time (which is harmful in elderly patients) and is more expensive, which is why several studies recommend using PVP over PKP\u003csup\u003e\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e,\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e,\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e\u003c/sup\u003e. Measurements were made with radiographs. We used this technique because it is easy to use, it can be performed intra-operatively and it allows us to study the vertebral body in different positions (standing and prone position). The gold-standard technique for making measurements is CT-scan. However, few hospitals can perform intraoperative CT-scan, and, in addition, it would mean exposing the patient to high doses of ionizing radiation. There may be other factors which influence the restoration of vertebral height that we have not collected. To understand factors involved in changes in the vertebral body height better, it would be interesting to make a comparison between a conservatively treated group and a surgical group. However, our present aim was to focus exclusively on vertebrae treated with vertebral augmentation.\u003c/p\u003e "},{"header":"Conclusion","content":" \u003cp\u003eOur study found that the patient\u0026rsquo;s position change (from standing to prone position) and vertebral augmentation produced an increase in the vertebral body height. After surgery there is a progressive collapse of the vertebral body that returns to pre-surgical values. The main factors that favor vertebral height restoration are: grade III collapse, IVVC, and vertebral augmentation technique. In contrast, a thoracolumbar location influenced vertebral height restoration negatively.\u003c/p\u003e "},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eACKNOWLEDGEMENTS\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe thank Ruth Breeze for the language editing of the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAUTHOR CONTRIBUTIONS\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eJ.P., M.A designed the study. J.P, R.L and M.A carried out data collection. J.P performed data analysis. All authors wrote the manuscript, critically reviewed and revised the manuscript for content and approved the manuscript for publication.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDECLARATION OF CONFLICTING INTERESTS\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declares that there is no conflict of interest.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFUNDING\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors received no financial support for the research, author- ship, and/or publication of this article.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eAnderson PA, Froyshteter AB, Tontz WL. 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Vertebroplasty versus kyphoplasty in osteoporotic vertebral compression fracture: a meta-analysis of prospective comparative studies. \u003cem\u003eInt Orthop\u003c/em\u003e\u003cstrong\u003e39\u003c/strong\u003e, 491\u0026ndash;500. https://doi.org/10.1007/s00264-014-2525-5 (2015).\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Vertebroplasty, Osteoporosis, Vertebral compression fractures, Radiography, Pain","lastPublishedDoi":"10.21203/rs.3.rs-430234/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-430234/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eChanges in vertebral body height depend on various factors which were analyzed in isolation and not as a whole. The aim of this study is to analyze what factors might influence restoration of vertebral body height after vertebral augmentation. We analyzed 48 patients (108 vertebrae) with osteoporotic vertebral fractures underwent vertebral augmentation when conservative treatment proved unsatisfactory. Analyses were carried out at the time of the fracture, during surgery (pre-cementation and post-cementation), at first medical check-up (6 weeks post-surgery) and at last medical check-up. Average vertebral height was measured and differences from preoperative values calculated at each timepoint. Pearson correlation coefficient and linear multivariable regression were carried out at the different timepoints. The time since vertebral fracture was 60.4\u0026thinsp;\u0026plusmn;\u0026thinsp;41.7 days. Patients\u0026rsquo; average age was 70.9\u0026thinsp;\u0026plusmn;\u0026thinsp;9.3-years. The total follow-up was 1.43\u0026thinsp;\u0026plusmn;\u0026thinsp;1-year. After vertebral cementation there was an increase in vertebral body height of +\u0026thinsp;0.3cm (13.6%). During post-operative follow-up, there was a progressive collapse of the vertebral body and pre-surgical height was reached. The factors that most influenced vertebral height restoration were: grade III collapse, intervertebral-vacuum-cleft (IVVC), and use of a flexible trocar before cement augmentation. The factor that negatively influenced vertebral body height restoration was location in the thoracolumbar spine.\u003c/p\u003e","manuscriptTitle":"Vertebral body height changes in acute symptomatic osteoporotic vertebral compression fractures treated with vertebral cement augmentation. Which factors affect vertebral body height?","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-04-21 21:50:23","doi":"10.21203/rs.3.rs-430234/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"4aad256b-133b-4072-bd7c-9c3e8d1b7fe5","owner":[],"postedDate":"April 21st, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":3813472,"name":"Rheumatology"},{"id":3813473,"name":"Orthopedics"}],"tags":[],"updatedAt":"2022-01-17T06:44:11+00:00","versionOfRecord":[],"versionCreatedAt":"2021-04-21 21:50:23","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-430234","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-430234","identity":"rs-430234","version":["v1"]},"buildId":"rHA-KDH7Qsr4HCuvH75dn","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}