WT1 expression in endometrioid ovarian carcinoma with and without associated endometriosis

Stewart CJ, C J R Stewart, Colin J.R. Stewart, B A Brennan, Barbara A. Brennan, Brennan BA, Chan T, T Chan, James L. Netreba, J Netreba, Netreba J
Pathology · 2008 · vol. 40(6) , pp. 592–599 · doi:10.1080/00313020802320697 · PMID:18752126 · W2094114213
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This study examined WT1 expression in endometrioid ovarian carcinoma, comparing cases with and without associated endometriosis to identify potential differences.

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Abstract

AimsTo determine how frequently endometrioid ovarian carcinomas (EOC) express WT1 protein, and to correlate the results with the presence of endometriosis and p53 immunoreactivity.MethodsForty-one grade 1-2 EOC were stained immunohistochemically for WT1 and p53 proteins. Twenty-one tumours were associated with endometriosis and 20 cases lacked such an association. WT1 expression in the tumour cell nuclei and/or cytoplasm was recorded. Nuclear p53 staining was assessed as diffuse (>50% cells positive), focal, or negative.ResultsFour of the 20 (20%) tumours in the endometriosis negative group showed nuclear WT1 staining, while none of the endometriosis-associated EOC was positive (p < 0.05). Two of the immunoreactive cases exhibited sertoliform/sex cord-like patterns. Focal cytoplasmic WT1 labelling was present in seven EOC, three of which showed sertoliform, spindle cell or corded and hyaline patterns. There was no correlation between WT1 expression and p53 immunoreactivity.ConclusionsNuclear WT1 expression is present in a minority of EOC and this should be considered if immunohistochemistry is used as an adjunct in sub-typing ovarian carcinomas. The negative correlation of WT1 staining with endometriosis supports the possibility that some EOC, including unusual histological variants, arise from the ovarian surface epithelium. Further studies of EOC should document any association with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Carcinoma, Endometrioid Endometriosis Ovarian Neoplasms WT1 Proteins Adult Aged Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Endometriosis Endometriosis Endometriosis Female Humans Immunohistochemistry Middle Aged Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Tumor Suppressor Protein p53

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