The Effects of Mifepristone and Tamoxifene on the Expressions of NF-κ B and Cytokine of Adenomyosis

Objective: To investigate the effects of Mifepristone and Tamoxifene on the expression of NF-κ B p65 mRNA, NF-κ B, PDGF-A and TGF-β of the adenomyosis. Methods: 46 cases of adenomyosis were randomly divided into 3 groups: Mifepristone group, Tamoxifene group, and the control group. Cytokines NF-κ B p65 mRNA was measured by ISH. The expression of NF-κ B, PDGF-A, and TGF-β was assayed by immunohistochemistry. Results: The expression intensity of NF-κ B p65 mRNA ,NF-κ B,PDGF-A and TGF-β was higher in control group, orderly decreased to Tamoxifene group, and then Mifepristone group, there was significant difference among them. The expression of NF-κ B was positive correlation with the expression of PDGF-A and TGF-β, respectively. Conclusions: Mifepristone and Tamoxifene could inhibit the production of NF-κ B p65 mRNA and NF-κ B in adenomyosis, and induced the down regulation of the expression of PDGF-A and TGF-β also.