Effects of levonorgestrel-releasing intrauterine system in the treatment of patients with adenomyosis

Objective To study the efficacy of Levonorgestrel-releasing intrauterine system(LNG-IUS Band name: Mirena) on the treatment of adenomyosis.Methods 65 patients with adenomyosis who received LNG-IUS placement recruited in this study.The visual analogue seale(VAS) scores,menstrual blood volume and uterine volume were compared before and after 6 and 12 months LNG-IUS placement.Results Compared with before treatment,dysmenorrhea was completely relieved or significantly alleviated in all patients after 6 month treatment of LNG-IUS.The mean VAS scores dropped from 81.3±9.4 to 16.8±12.1(P0.01),the menstrual blood volume reduced significantly [100% vs(25.3±12.2)%,P0.01].After 12 months,hemoglobin recovered to normal in 30 patients with anemia(P0.01).Uterine volume reduced and had significantly difference compared to before treatment(P0.05).Conclusions LNG-IUS is an efficient method to treat adenomyosis,it can alleviate dysmenorrheal,decrease menstrual blood volume and reduce uterus volume.