Adjunctive Dapsone Therapy in Pediatric Lupus Nephritis: Clinical Insights

Adjunctive Dapsone Therapy in Pediatric Lupus Nephritis: Clinical Insights | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 22 November 2025 V1 Latest version Share on Adjunctive Dapsone Therapy in Pediatric Lupus Nephritis: Clinical Insights Authors : Shuo-Hung Wang 0009-0007-4807-6222 , Hsin-Jou Chen , Su-Boon Yong 0000-0002-5175-908X [email protected] , Chia-Jung Li , Xiao-Ling Liu , and Chao-Yi Wu Authors Info & Affiliations https://doi.org/10.22541/au.176380223.32087301/v1 184 views 110 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Childhood-onset systemic lupus erythematosus (cSLE) often presents with severe disease and frequent lupus nephritis (LN). While standard immunosuppressive therapies are effective for most patients, some develop refractory cutaneous vasculitis, bullous lesions, or neutrophil-driven inflammation. Dapsone, a sulfone with anti-neutrophilic and anti-inflammatory properties, has been used off-label in pediatric SLE with encouraging results. Case reports and small series show improvement in vasculitic and bullous manifestations and allow steroid tapering without worsening renal function. Its benefits in LN are largely indirect, mediated through reduction of neutrophil-mediated vascular injury. Safety concerns—including hemolysis, methemoglobinemia, and hypersensitivity—require careful monitoring. Although evidence remains limited, dapsone may serve as a practical adjunct for selected children with refractory SLE. Supplementary Material File (final_dapsone_20251118.docx) Download 31.93 KB Information & Authors Information Version history V1 Version 1 22 November 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords autoimmunity inflammation pediatrics Authors Affiliations Shuo-Hung Wang 0009-0007-4807-6222 Kaohsiung Medical University Department of Medical Laboratory Science and Biotechnology View all articles by this author Hsin-Jou Chen China Medical University School of Chinese Medicine View all articles by this author Su-Boon Yong 0000-0002-5175-908X [email protected] China Medical University Hospital View all articles by this author Chia-Jung Li Kaohsiung Veterans General Hospital View all articles by this author Xiao-Ling Liu China Medical University Hospital View all articles by this author Chao-Yi Wu Taoyuan Chang Gung Memorial Hospital View all articles by this author Metrics & Citations Metrics Article Usage 184 views 110 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Shuo-Hung Wang, Hsin-Jou Chen, Su-Boon Yong, et al. Adjunctive Dapsone Therapy in Pediatric Lupus Nephritis: Clinical Insights. Authorea . 22 November 2025. 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