New amide compounds used for treatment of gynecological diseases e.g. endometriosis, for female fertility control and female hormone replacement therapy, has general formula

Amide compounds (I), are new. Amide compounds of formula (I), are new. A : H, Z substituted 1-8C-alkyl, 2-8C-alkenyl, 2-8C alkinyl, M substituted 3-10C-cycloalkyl, 3-12-membered heterocycloalkyl residue, where Z is cyano, halogen, hydroxy, nitro, -C(O)R 8>, CO 2R 8>, -O-R 8>, -S-R 8>, SO 2NR 5>R 6>, -C(O)-NR 5>R 6>, -OC(O)-NR 5>R 6>, -C=NOR 8>, -NR 5>R 6>, -PO 3(R 8>) 2, -NR 7>COR 8>, -NR 7>CSR 8>, -NR 7>S(O)R 8>, -NR 7>S(O) 2R 8>, -NR 7>CONR 5>R 6>, -NR 7>COOR 8>,-NR 7>C(NH)NR 5>R 6>, -NR 7>CSNR 5>R 6>, -NR 7>S(O)NR 5>R 6>, -NR 7>S(O) 2NR 5>R 6>, -S(O)R 8>,-S(O)NR 5>R 6>, -S(O) 2R 8>, -SO 2OR 8>, -CSNR 5>R 6>, -CR 8>(OH)-R 8> and M is 1-6C-alkyl or - COR 8> , CO 2R 8> , -0-R 8> , or -NR 5>R 6> group, where R 8> is hydrogen or 1-6C-aKyl, 2-8C-alkenyl, 2-8C-alkinyl, 3-10C-cycloalkyl, 6-12C-aryl or a partially or completely fluorinated 1-3C-alkyl residue and R 5> and R 6> are independently of each other, a hydrogen, 1-6C-alkyl, 2-6C-alkenyl, 2-8C-alkinyl, 3-10C-cycloalkyl, 6-12C-aryl residue, or a hydroxy group, and R 7> is a hydrogen, 1-6C-aIkYl, 2-8C-alkenyl and , alkinyl, 3-10C-cycloalkyl or a 6-12C aryl R 1>,R 2>independently an unbranched or branched 1-5C-alkyl group or form a 3-7 members ring with the C-atom, R 3>H, K substituted 1-8C-alkyl, 2-8C-alkenyl, 2-8C-alkinyl, 3-10C-cycloalkyl, 3-12-member heterocycloalkyl residue with L substituted, mono or bicyclic 6-12C-aryl or 3-12-member heterocycloalkyl residue, where K is cyano, halogen, hydroxy, nitro, - C(O)R 4> , CO 2R 4>, -O-R 4>,-S-R 4>, SO 2NR 5>R 6>,- C(O)-NR 5>R 6>, -OC(O)-NR 5>R 6>, -C=NOR 4>,-NR 5>R 6>, where L is 1-8C alkyl, 2-8C akenyl, partially or completely fluorinated 1-6C alkyl, 1-6C alkoxy, 1-6 alkoxy-1-6C alkyl, 1-6C alkoxy-1-6C alkoxy, mono or bicyclic (CH 2) pC 3-C 10 cycloalkyl, mono or bicyclic 3-12 membered (CH 2) p heterocyclo alkyl residue, (CH 2) pCN, (CH 2) pC 6-C 12 aryl residue, (CH 2) p-heteroaryl residue,-O-CH=CH- or (CH 2) n+2, where n is 1 or 2, p=0,1,2,3,4,5 or 6 X : an oxygen or two hydrogen atoms Y : (CH 2) m, -CH=CH, where m is 0 or 1 R 4unsubtituted or substituted up to 1-3 residue, mono or bicyclic 3-12 membered aromatic or hetero aromatic residue or bicyclic compound having general formulae (II) or (III). An independent claim is also included for a pharmaceutical composition which comprises compound (I), an additional active substance i.e. selective estrogen receptor modulator and a pharmaceutically acceptable carrier. [Image] [Image] - ACTIVITY : Gynecological Analgesic Cytostatic. - MECHANISM OF ACTION : None given.