Synthesis of dienogest

Objective To research the synthetic procedure of dienogest. Methods Dienogest was prepared from estra-4,9-diene-3,17-dione,2,2-dimethylpropane-1,3-diol via 3-position ketalation,17-epoxidation,ring cleavage and 3-position hydrolysis reactions. Results The structure of target compound was confirmed by 1H-NMR,13C-NMR,MS and IR.The overall yield was 45.5%. Conclusions The process should have certain value for industrial application considering its availability of the raw materials,simple operation and mild reacting condition.