PENGARUH HYPERBARIC OXYGEN (HBO) TERHADAP EKSPRESI HYPOXIA INDUCED FACTOR-1 ALPHA (HIF-1 ALPHA), VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) DAN LUAS JARINGAN ENDOMETRIOTIK PADA MENCIT MODEL ENDOMETRIOSIS

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PENGARUH HYPERBARIC OXYGEN (HBO) TERHADAP EKSPRESI HYPOXIA INDUCED FACTOR-1 ALPHA (HIF-1 ALPHA), VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) DAN LUAS JARINGAN ENDOMETRIOTIK PADA MENCIT MODEL ENDOMETRIOSIS

Cut Rizki Mustika

2016 · W2744953611

Lab / animal OA: green CC0

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This study investigated the effect of hyperbaric oxygen on HIF-1 alpha, VEGF expression, and endometriotic tissue area in a mouse model of endometriosis.

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This thesis investigated the effects of hyperbaric oxygen therapy on hypoxia induced factor-1 alpha, vascular endothelial growth factor expression, and the area of endometriotic tissue in a murine model of endometriosis. The study utilized mice to evaluate how increased oxygen levels influence molecular markers associated with angiogenesis and hypoxia within ectopic endometrial lesions. Results indicated that hyperbaric oxygen treatment significantly reduced the expression of HIF-1 alpha and VEGF, leading to a decrease in the size of endometriotic implants compared to control groups. This paper is centrally about endometriosis — specifically examining the therapeutic impact of hyperbaric oxygen on lesion progression and related molecular pathways in an animal model.

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Abstract

Hipoksia pada endometriosis akan meningkatkan ekspresi Hypoxia Inducble Factor-1 alpha (HIF-1 alpha) selanjutnya meningkatkan ekspresi Vascular Endothelial Growth Factor (VEGH). Hyperbaric Oxygen (HBO) dapat menurunkan ekspresi HIF-1 alpha karena meningkatkan ubiquitinisasi HIF-1 alpha. inilah peluang bagi HBO agar dapat digunakan sebagai salah satu modalitas pendukung pengobatan endometriosis.

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IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA TESIS PENGARUH HYPERBARIC OXYGEN CUT MUSTIKA, dr. IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA TESIS PENGARUH HYPERBARIC OXYGEN CUT MUSTIKA, dr. IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA TESIS PENGARUH HYPERBARIC OXYGEN CUT MUSTIKA, dr. IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA TESIS PENGARUH HYPERBARIC OXYGEN CUT MUSTIKA, dr. IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA TESIS PENGARUH HYPERBARIC OXYGEN CUT MUSTIKA, dr. IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA TESIS PENGARUH HYPERBARIC OXYGEN CUT MUSTIKA, dr. IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA TESIS PENGARUH HYPERBARIC OXYGEN CUT MUSTIKA, dr. IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA TESIS PENGARUH HYPERBARIC OXYGEN CUT MUSTIKA, dr. IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA TESIS PENGARUH HYPERBARIC OXYGEN CUT MUSTIKA, dr. IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA TESIS PENGARUH HYPERBARIC OXYGEN CUT MUSTIKA, dr. IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA TESIS PENGARUH HYPERBARIC OXYGEN CUT MUSTIKA, dr.

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endometriosis

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