Management of Pelvic Endometriosis with a GnRH Analogue

In: GnRH Analogues in Reproduction and Gynecology · 1990 · pp. 43–47 · doi:10.1007/978-94-009-0721-8_6 · W1598199602
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This Phase III trial evaluated buserelin, a GnRH analogue, for managing severe pelvic endometriosis by inducing a reversible hypoestrogenic state to promote disease regression.

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This paper reports on a Phase III clinical trial evaluating buserelin, a GnRH analogue, for the management of patients with severe pelvic endometriosis. It describes the rationale that GnRH analogues can reversibly suppress the hypothalamic-pituitary-ovarian axis, producing a hypoestrogenic state intended to allow regression of endometriosis lesions. A major stated caveat is the broader context that surgical treatment can remove reproductive and hormonal functions, motivating pharmacologic suppression rather than surgery. This paper is centrally about endometriosis — it specifically studies buserelin as a GnRH analogue treatment for severe pelvic endometriosis.

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Abstract

Pelvic endometriosis remains a difficult gynaecological problem to manage and yet the progression of the disease can be very detrimental to the health of the patients. Surgical treatment often involves removal of the reproductive as well as the hormonal functions of the patient. With the discovery of GnRH analogues ability to induce reversible suppression of the hypothalamic-pituitary-ovarian axis, it becomes possible to produce a hypoestrogenic state which allows regression of the disease. This paper reports on a Phase III clinical trial on the use of buserelin (Hoechst China Ltd) in the management of patients with severe pelvic endometriosis. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others Author information Authors and Affiliations Editor information Rights and permissions Copyright information © 1990 Kluwer Academic Publishers About this chapter Cite this chapter Li, D.F.H., Ho, P.C. (1990). Management of Pelvic Endometriosis with a GnRH Analogue. In: Vickery, B.H., Lunenfeld, B. (eds) GnRH Analogues in Reproduction and Gynecology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0721-8_6 Download citation DOI: https://doi.org/10.1007/978-94-009-0721-8_6 Publisher Name: Springer, Dordrecht Print ISBN: 978-94-010-6809-3 Online ISBN: 978-94-009-0721-8 eBook Packages: Springer Book Archive

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