Survey and Analysis of Awareness, Participation, and Satisfaction Rate of Stroke Patients in the Xuzhou Region regarding Rehabilitation and Related Factors

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Abstract Background Post-Rehabilitation is crucial for the recovery of stroke patients after a stroke. However, current research lacks investigations into stroke patients' awareness of the need for rehabilitation after a stroke. Additionally, there is a shortage of studies assessing the satisfaction levels of stroke patients who have undergone rehabilitation.Objective Investigating the awareness, participation, and satisfaction of stroke patients in the Xuzhou Region regarding rehabilitation, with an analysis of relevant factors.Method A total of 1654 patients diagnosed with stroke at Xuzhou Medical University Affiliated Hospital between January 2021 and June 2022 were selected. Telephone follow-up interviews were conducted with these patients six months to one year after their discharge to collect information.Results Among 1654 patients, 219 were lost to follow-up, and 337 died. There were 1098 valid samples. Among these, 406 patients (36.98%) were aware that stroke required rehabilitation, 306 patients (27.87%) participated in rehabilitation, and 146 (47.71%) were relatively satisfied with rehabilitation, and 53 (17.32%) were satisfied. There was a positive correlation between mRS score and awareness rate (r = 0.635, p < 0.001), as well as between mRS score and participation rate (r = 0.589, p < 0.001). Conversely, mRS score exhibited a negative correlation with satisfaction rate (r=-0.503, p < 0.001).Conclusion The awareness, participation, and satisfaction levels of stroke patients regarding post-stroke rehabilitation remain less than ideal. Patients with higher levels of disability have a greater awareness of and participation in post-stroke rehabilitation. However, their satisfaction rates tend to be lower.
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Survey and Analysis of Awareness, Participation, and Satisfaction Rate of Stroke Patients in the Xuzhou Region regarding Rehabilitation and Related Factors | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Survey and Analysis of Awareness, Participation, and Satisfaction Rate of Stroke Patients in the Xuzhou Region regarding Rehabilitation and Related Factors Yang Huo, Sijie Liang, Quanqing Wei, Yunyun Zhang, Ting Zhang, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6586964/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 10 You are reading this latest preprint version Abstract Background Post-Rehabilitation is crucial for the recovery of stroke patients after a stroke. However, current research lacks investigations into stroke patients' awareness of the need for rehabilitation after a stroke. Additionally, there is a shortage of studies assessing the satisfaction levels of stroke patients who have undergone rehabilitation. Objective Investigating the awareness, participation, and satisfaction of stroke patients in the Xuzhou Region regarding rehabilitation, with an analysis of relevant factors. Method A total of 1654 patients diagnosed with stroke at Xuzhou Medical University Affiliated Hospital between January 2021 and June 2022 were selected. Telephone follow-up interviews were conducted with these patients six months to one year after their discharge to collect information. Results Among 1654 patients, 219 were lost to follow-up, and 337 died. There were 1098 valid samples. Among these, 406 patients (36.98%) were aware that stroke required rehabilitation, 306 patients (27.87%) participated in rehabilitation, and 146 (47.71%) were relatively satisfied with rehabilitation, and 53 (17.32%) were satisfied. There was a positive correlation between mRS score and awareness rate (r = 0.635, p < 0.001), as well as between mRS score and participation rate (r = 0.589, p < 0.001). Conversely, mRS score exhibited a negative correlation with satisfaction rate (r=-0.503, p < 0.001). Conclusion The awareness, participation, and satisfaction levels of stroke patients regarding post-stroke rehabilitation remain less than ideal. Patients with higher levels of disability have a greater awareness of and participation in post-stroke rehabilitation. However, their satisfaction rates tend to be lower. Health sciences/Diseases Health sciences/Health care Health sciences/Medical research Health sciences/Risk factors Stroke Rehabilitation Survey PAPER CONTEXT Main findings: In Xuzhou, stroke patients lack awareness of post-stroke rehabilitation, resulting in low participation and satisfaction rates Added knowledge: Despite studies affirming the vital role of rehabilitation in stroke recovery, awareness remains insufficient among patients, families, and some healthcare professionals. Global health impact for policy and action: Governments, particularly in developing countries, must enhance public awareness to optimize rehabilitation's role in preventing and treating strokes. Background Stroke is a neurological condition that occurs suddenly and is identified by the abrupt onset of symptoms and clinical manifestations related to brain function[1]. Globally, the prevalence of stroke is estimated at 62 million and is expected to reach 77 million by 2030[2]. Stroke is the second most common cause of global disability-adjusted life-years (DALYs) In 2016[3]. Disability is a common stroke complication that affects patients' ability to perform daily activities and imposes a heavy burden on patients, families, and society[4]. Stroke rehabilitation is an effective method for reducing disability and is an essential key element in the organized management of stroke[5]. However, many stroke patients do not receive appropriate rehabilitation services, and the utilization rate of post-stroke rehabilitation services varies greatly across different regions and countries[6–8]. In the management of chronic diseases, several studies[9, 10] investigate the awareness, treatment, and compliance rates of patients, with a particular focus on hypertension. These studies typically explore patients' knowledge of their diagnosis, medication adherence, and the efficacy of treatment. The management of post-stroke disabilities shares similarities with chronic disease management, as both require long-term management. However, while chronic diseases are predominantly controlled through medication, post-stroke disabilities are managed through rehabilitation methods. Therefore, this study aims to investigate the awareness, participation, satisfaction rate with stroke rehabilitation and analysis of relevant factors. Patients and methods Patients : Between January 2021 and April 2022, a total of 1654 stroke patients were admitted to the Affiliated Hospital of Xuzhou Medical University and randomly selected for this study. The inclusion criteria were as follows: 1) diagnosis of stroke according to computed tomography or magnetic resonance imaging, 2) patients who completed the telephone interview 3) long-term residence in the Xuzhou area. The exclusion criteria were: 1) severe consciousness or mental disorders in the past that were not caused by stroke. 2) Other diseases causing disabilities. The Ethics Committee of the Affiliated Hospital of Xuzhou Medical University approved this research (XYFY2021-KL269-01), and the study methods followed the principles of the Declaration of Helsinki. This study was registered in the China Clinical Trials Registry (No. ChiCTR2100048154). Methods : The research team independently designed a survey questionnaire based on the experimental objectives, focusing primarily on three aspects:① Basic information, including age, gender, marital status, residential area, educational level, etc.; ② Medical details, such as disability severity, type and frequency of strokes, hypertension, diabetes, etc.; ③ Awareness, participation, and satisfaction rates regarding rehabilitation. The modified Rankin Scale (mRS) was used to assess patients' disability levels, with 0 and 1 representing no disability, 2 indicating slight disability, 3 indicating moderate disability, 4 indicating moderately severe disability, and 5 indicating severe disability. To ensure consistency and accuracy in questionnaire completion, the surveyors underwent standardized training to clarify principles and guidelines for filling out the questionnaire. The survey was conducted via telephone, and patients who did not answer calls on three separate occasions at different times were considered lost to follow-up. Statistical Analysis The data were analyzed using SPSS 23.0 software. Categorical variables were presented as number (percentage) while continuous variables were reported as mean and standard deviation (SD). Univariate analysis utilized chi-square tests and rank-sum tests, and multivariate analysis was performed using Logistic regression. Spearman correlation analysis was employed to explore the relationships between disability severity and awareness, participation, and satisfaction rates. A significance level of p < 0.05 was considered statistically significant. Results Basic Information In the 1098 valid samples, the average age was 63.79 ± 10.95 years. Among them, there were 677 males (61.66%) and 421 females (38.34%). Urban residents accounted for 51.55%, Table 1. Disease Characteristics and Disability Status The main type of stroke was ischemic, accounting for 867 cases (78.96%), while hemorrhagic stroke occurred in 231 cases (21.04%). There were 195 cases with a history of stroke (17.76%). The prevalence of hypertension was 54.19%, and the prevalence of diabetes was 25.32% (Table 1). According to the mRS score, 170 individuals had slight disability (15.48%), 95 had moderate disability (8.65%), 90 had moderately severe disability (8.20%), and 65 had severe disability (5.92%). Awareness, participation, and satisfaction rates regarding rehabilitation In 1098 stroke patients, the awareness rate and participation rate of stroke rehabilitation were 36.98% (n = 406) and 27.87% (n = 306). Among the patients who received rehabilitation treatment, 199 were satisfied(including fairly and quite satisfied), resulting in a satisfaction rate of 65.03%. A univariate analysis was conducted, revealing statistically significant differences (p < 0.05) in the awareness and participation rates of rehabilitation among stroke patients based on various factors, including age, marital status, residential area, stroke type, stroke frequency, hypertension, and mRS score (Table 1). Additionally, statistically significant differences (p < 0.05) in satisfaction with rehabilitation were observed among patients of different ages and mRS scores (Table 2). The significant variables identified in the univariate analysis were assigned as dependent variables. Logistic regression analyses were performed with awareness, participation, and satisfaction as separate dependent variables. The results indicated a significant correlation between age, stroke type, and mRS score with patients' awareness and participation in rehabilitation (p < 0.05), as shown in Tables 3 and 4. The relationship between disability and awareness, participation and satisfaction with stroke Spearman correlation analysis shows that the mRS score was positively correlated with awareness(r = 0.635,P<0.001) and participation(r = 0.589,P<0.001), but negatively correlated with satisfaction(r=-0.503,P<0.001), suggesting that patients with higher mRS scores had higher levels of awareness and participation, but lower levels of satisfaction. Dicussion The results of this study indicate that the awareness rate of rehabilitation among stroke patients in the Xuzhou region is 36.98%, implying that less than half of the stroke patients are informed about stroke rehabilitation. This may be due to insufficient education about rehabilitation or a lack of awareness among patients regarding the importance of rehabilitation. The participation rate is 27.87%, which could be attributed, on one hand, to some patients perceiving their physical condition as satisfactory and not seeing the necessity for rehabilitation. On the other hand, it might be because some patients with severe disabilities remain skeptical about the effectiveness of rehabilitation, believing that the outcomes may not meet their expectations, leading to their non-participation. Finally, there are also patients who are unaware of the need for rehabilitation. The satisfaction rate is 65.03%, indicating that although a certain proportion of patients participated in rehabilitation, many are still dissatisfied with the rehabilitation process. This dissatisfaction may stem from rehabilitation plans that do not cater to their needs, insignificant rehabilitation outcomes, or a lack of adequate support and feedback. Enhancing awareness, participation, and satisfaction rates among stroke patients is crucial. This requires a series of measures, including improved promotion and education, personalized rehabilitation plans, additional feedback mechanisms, and possibly a more comprehensive healthcare system. Additionally, interdisciplinary teamwork should be strengthened, extending rehabilitation beyond rehabilitation medicine to fields such as neurology. Finally, establishing a comprehensive rehabilitation team comprising doctors, nurses, physical therapists, psychologists, and other professionals can better meet the diverse rehabilitation needs of patients. It found that while rural stroke patients had higher awareness and participation rates, their satisfaction rates were lower than those of urban patients. This may be attributed to the more severe disability status of rural patients, their strong desire to receive training, but limited access to quality rehabilitation training due to the shortage of medical resources and economic reasons in rural areas. The survey found that many stroke patients living in rural areas received rehabilitation training at the county-level hospital or even at the township health center, which indicates that although rehabilitation medicine has developed rapidly in Xuzhou and has reached the township level on a large scale, it is not yet strong enough. This, to some extent, also reflects certain phenomena in the development of rehabilitation medicine in China. Age, stroke type, and mRS (Modified Rankin Scale) score show significant correlations with patient awareness and participation in rehabilitation (p < 0.05). Patients of different ages and mRS scores exhibit statistically significant differences in stroke rehabilitation satisfaction rates (p < 0.05). Older patients tend to have lower awareness, participation, and satisfaction rates in stroke rehabilitation. Advanced age may be associated with less understanding of health management and rehabilitation concepts. As patients age, some may be less familiar or comfortable with modern technology, such as smartphones or computers, potentially affecting their ability to access rehabilitation information and leading to insufficient awareness of rehabilitation. Older patients may face physical limitations that hinder active participation in rehabilitation activities. Factors like pain, reduced mobility, or chronic conditions could impact their rehabilitation progress. Moreover, older patients may be more prone to feelings of anxiety, depression, or a negative attitude toward the rehabilitation process. Their rehabilitation needs may not be as strong as those of younger individuals, leading to lower levels of participation and satisfaction. Similar patterns may be observed among patients with varying degrees of disability. This study found that stroke patients with higher mRS (Modified Rankin Scale) scores have higher awareness and participation rates but lower satisfaction rates. This suggests that patients with more severe disabilities have higher expectations for improving their functional abilities, enhancing their quality of life, and reintegrating into family and society. However, due to the severity of their condition, unrealistic expectations, or insufficient understanding of rehabilitation, these expectations are not always met. Therefore, rehabilitation professionals and therapists must enhance their skills and provide education on rehabilitation knowledge to patients and their families, allowing for a better understanding of rehabilitation concepts. This study also has certain limitations. Firstly, it adopts a cross-sectional study design, where all data and information are collected simultaneously, limiting causal inferences. The study can only propose hypotheses regarding the factors related to the awareness, participation, and satisfaction rates of stroke patients in rehabilitation, without establishing causal relationships. Secondly, the study is a single-center research, which restricts the generalizability of the results, as there may be variations across different regions and medical institutions. Future research could employ more rigorous study designs for long-term follow-ups to delve deeper into the relationships among awareness, participation, and satisfaction rates of stroke patients in rehabilitation, as well as the associated factors. Conclusion The awareness, participation, and satisfaction levels of stroke patients regarding stroke rehabilitation remain less than ideal. Patients with higher levels of disability have a greater awareness of and participation in stroke rehabilitation. However, their satisfaction rates tend to be lower. Government should take measures to promote the high-quality development of rehabilitation medicine. Healthcare workers should strengthen education and dissemination of rehabilitation knowledge to help them better support patients and their families in establishing correct rehabilitation concepts. By taking these steps, we can improve the quality of life and outcomes for stroke patients. Declarations Acknowledgments The authors would like to thank every patient and family member interviewed. We also appreciate the assistance provided by Mr. Shengli Li from the Clinical Research Institute of the Affiliated Hospital of Xuzhou Medical University in the fields of statistics and data analysis. Disclosure statement No potential conflict of interest was reported by the author(s). Ethical statement Informed consent was obtained from all individual participants included in this study, or from their legal guardians in cases where participants were minors or lacked decision-making capacity. The study protocol adhered to the ethical principles outlined in the Declaration of Helsinki. The Ethics Committee of the Affiliated Hospital of Xuzhou Medical University approved this research (XYFY2021-KL269-01). This study was registered in the China Clinical Trials Registry (No. ChiCTR2100048154). Funding This work was supported by National Key Research and Development Program of China (No.2020YFC2006604). Availability of data and materials The datasets used during the current study are available from the corresponding author on reasonable request. Conflict of interest declaration No potential conflict of interest was reported by the author(s). Authors’ Contributions Yang Huo: research design, data collection and analysis, and paper writing; Sijie Liang: research design; Quanqing Wei: data collection; Yunyun Zhang and Ting Zhang: paper writing; Jie Xiang: research design, paper guidance, and acquisition of research funds. References Boursin P, Paternotte S, Dercy B, Sabben C, Maïer B. [Semantics, epidemiology and semiology of stroke]. Soins. 2018;63(828):24 − 7. Epub 2018/09/15. doi: 10.1016/j.soin.2018.06.008. PubMed PMID: 30213310. Mukherjee D, Patil CG. Epidemiology and the global burden of stroke. World Neurosurg. 2011;76(6 Suppl):S85-90. Epub 2012/01/04. doi: 10.1016/j.wneu.2011.07.023. PubMed PMID: 22182277. Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(5):439 − 58. Epub 2019/03/16. doi: 10.1016/s1474-4422(19)30034-1. PubMed PMID: 30871944; PubMed Central PMCID: PMCPMC6494974. Rigby H, Gubitz G, Phillips S. A systematic review of caregiver burden following stroke. Int J Stroke. 2009;4(4):285 − 92. Epub 2009/08/20. doi: 10.1111/j.1747-4949.2009.00289.x. PubMed PMID: 19689757. Thorsén AM, Holmqvist LW, de Pedro-Cuesta J, von Koch L. A randomized controlled trial of early supported discharge and continued rehabilitation at home after stroke: five-year follow-up of patient outcome. Stroke. 2005;36(2):297–303. Epub 2004/12/25. doi: 10.1161/01.STR.0000152288.42701.a6. PubMed PMID: 15618441. Bright T, Wallace S, Kuper H. A Systematic Review of Access to Rehabilitation for People with Disabilities in Low- and Middle-Income Countries. Int J Environ Res Public Health. 2018;15(10). Epub 2018/10/04. doi: 10.3390/ijerph15102165. PubMed PMID: 30279358; PubMed Central PMCID: PMCPMC6210163. McKevitt C, Fudge N, Redfern J, Sheldenkar A, Crichton S, Rudd AR, et al. Self-reported long-term needs after stroke. Stroke. 2011;42(5):1398 − 403. Epub 2011/03/29. doi: 10.1161/strokeaha.110.598839. PubMed PMID: 21441153. Ovbiagele B, Goldstein LB, Higashida RT, Howard VJ, Johnston SC, Khavjou OA, et al. Forecasting the future of stroke in the United States: a policy statement from the American Heart Association and American Stroke Association. Stroke. 2013;44(8):2361-75. Epub 2013/05/24. doi: 10.1161/STR.0b013e31829734f2. PubMed PMID: 23697546. Lu J, Lu Y, Wang X, Li X, Linderman GC, Wu C, et al. Prevalence, awareness, treatment, and control of hypertension in China: data from 1·7 million adults in a population-based screening study (China PEACE Million Persons Project). Lancet. 2017;390(10112):2549-58. Epub 2017/11/06. doi: 10.1016/s0140-6736(17)32478-9. PubMed PMID: 29102084. Kang SH, Kim SH, Cho JH, Yoon CH, Hwang SS, Lee HY, et al. Prevalence, Awareness, Treatment, and Control of Hypertension in Korea. Scientific Reports. 2019;9(1):10970. Epub 2019/07/31. doi: 10.1038/s41598-019-46965-4. PubMed PMID: 31358791; PubMed Central PMCID: PMCPMC6662850. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Revision requested 22 Jul, 2025 Reviews received at journal 12 Jul, 2025 Reviews received at journal 06 Jul, 2025 Reviewers agreed at journal 29 Jun, 2025 Reviewers agreed at journal 26 Jun, 2025 Reviewers invited by journal 26 Jun, 2025 Editor assigned by journal 25 Jun, 2025 Editor invited by journal 21 May, 2025 Submission checks completed at journal 12 May, 2025 First submitted to journal 12 May, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6586964","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":477841316,"identity":"ce73e35c-d6c1-4d8f-942f-ec8de4967851","order_by":0,"name":"Yang Huo","email":"","orcid":"","institution":"Xuzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Yang","middleName":"","lastName":"Huo","suffix":""},{"id":477841317,"identity":"3edb8440-e9e1-4b85-b2a0-8435e55dc446","order_by":1,"name":"Sijie Liang","email":"","orcid":"","institution":"The Affiliated Hospital of Xuzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Sijie","middleName":"","lastName":"Liang","suffix":""},{"id":477841318,"identity":"7a657025-b717-40ad-bcfc-fcb235706478","order_by":2,"name":"Quanqing Wei","email":"","orcid":"","institution":"Xuzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Quanqing","middleName":"","lastName":"Wei","suffix":""},{"id":477841319,"identity":"ccf43072-886b-47b9-af78-d93f229a5f36","order_by":3,"name":"Yunyun Zhang","email":"","orcid":"","institution":"Xuzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Yunyun","middleName":"","lastName":"Zhang","suffix":""},{"id":477841320,"identity":"dc9650b8-5266-4203-aab8-8ca94c1ebbbb","order_by":4,"name":"Ting Zhang","email":"","orcid":"","institution":"Xuzhou Medical University","correspondingAuthor":false,"prefix":"","firstName":"Ting","middleName":"","lastName":"Zhang","suffix":""},{"id":477841321,"identity":"3a4e38c7-caf9-4709-aadb-7c06c6d27542","order_by":5,"name":"Jie Xiang","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA3UlEQVRIiWNgGAWjYBACNvbG9g8fKmzk5NmbDz5IqKghrIWP5/Axxhln0owNe44lGzw4c4ywFjmJtDRm3rZDiQ03ctQkH7YwE+EwnjNmD3jYDhgz9pxhq0hsYGPgb+9OIOCXHnMDCZ47cuzsvcduJO6QYZA4c3YDIVsMJAwkngFtOZd2I/EMG4OBRC4BLRI5BhIJBodBfjErSGxjJkZLWprEgQSIFgbitPAcPmzYcAASyBIJZ47xEPSLfHtj4+O//yBR+fFHRY0cf3svfi0YgIc05aNgFIyCUTAKsAIAH4FQg0hOYEIAAAAASUVORK5CYII=","orcid":"","institution":"The Affiliated Hospital of Xuzhou Medical University","correspondingAuthor":true,"prefix":"","firstName":"Jie","middleName":"","lastName":"Xiang","suffix":""}],"badges":[],"createdAt":"2025-05-04 06:38:13","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6586964/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6586964/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":85641971,"identity":"4e664466-7337-4ebc-8afc-1b134924471b","added_by":"auto","created_at":"2025-06-30 07:48:06","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":416845,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6586964/v1/23060e14-36c7-43d3-8561-5ccef7380c1a.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Survey and Analysis of Awareness, Participation, and Satisfaction Rate of Stroke Patients in the Xuzhou Region regarding Rehabilitation and Related Factors","fulltext":[{"header":"PAPER CONTEXT","content":"\u003cp\u003eMain findings:\u003c/p\u003e\n\u003cp\u003eIn Xuzhou, stroke patients lack awareness of post-stroke rehabilitation, resulting in low participation and satisfaction rates\u003c/p\u003e\n\u003cp\u003eAdded knowledge:\u003c/p\u003e\n\u003cp\u003eDespite studies affirming the vital role of rehabilitation in stroke recovery, awareness remains insufficient among patients, families, and some healthcare professionals.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eGlobal health impact for policy and action:\u003c/p\u003e\n\u003cp\u003eGovernments, particularly in developing countries, must enhance public awareness to optimize rehabilitation\u0026apos;s role in preventing and treating strokes.\u003c/p\u003e"},{"header":"Background","content":"\u003cp\u003eStroke is a neurological condition that occurs suddenly and is identified by the abrupt onset of symptoms and clinical manifestations related to brain function[1]. Globally, the prevalence of stroke is estimated at 62\u0026nbsp;million and is expected to reach 77\u0026nbsp;million by 2030[2]. Stroke is the second most common cause of global disability-adjusted life-years (DALYs) In 2016[3]. Disability is a common stroke complication that affects patients' ability to perform daily activities and imposes a heavy burden on patients, families, and society[4]. Stroke rehabilitation is an effective method for reducing disability and is an essential key element in the organized management of stroke[5]. However, many stroke patients do not receive appropriate rehabilitation services, and the utilization rate of post-stroke rehabilitation services varies greatly across different regions and countries[6\u0026ndash;8]. In the management of chronic diseases, several studies[9, 10] investigate the awareness, treatment, and compliance rates of patients, with a particular focus on hypertension. These studies typically explore patients' knowledge of their diagnosis, medication adherence, and the efficacy of treatment. The management of post-stroke disabilities shares similarities with chronic disease management, as both require long-term management. However, while chronic diseases are predominantly controlled through medication, post-stroke disabilities are managed through rehabilitation methods. Therefore, this study aims to investigate the awareness, participation, satisfaction rate with stroke rehabilitation and analysis of relevant factors.\u003c/p\u003e"},{"header":"Patients and methods","content":"\u003cp\u003e\u003cb\u003ePatients\u003c/b\u003e: Between January 2021 and April 2022, a total of 1654 stroke patients were admitted to the Affiliated Hospital of Xuzhou Medical University and randomly selected for this study. The inclusion criteria were as follows: 1) diagnosis of stroke according to computed tomography or magnetic resonance imaging, 2) patients who completed the telephone interview 3) long-term residence in the Xuzhou area. The exclusion criteria were: 1) severe consciousness or mental disorders in the past that were not caused by stroke. 2) Other diseases causing disabilities. The Ethics Committee of the Affiliated Hospital of Xuzhou Medical University approved this research (XYFY2021-KL269-01), and the study methods followed the principles of the Declaration of Helsinki. This study was registered in the China Clinical Trials Registry (No. ChiCTR2100048154).\u003c/p\u003e \u003cp\u003e\u003cb\u003eMethods\u003c/b\u003e: The research team independently designed a survey questionnaire based on the experimental objectives, focusing primarily on three aspects:① Basic information, including age, gender, marital status, residential area, educational level, etc.; ② Medical details, such as disability severity, type and frequency of strokes, hypertension, diabetes, etc.; ③ Awareness, participation, and satisfaction rates regarding rehabilitation. The modified Rankin Scale (mRS) was used to assess patients' disability levels, with 0 and 1 representing no disability, 2 indicating slight disability, 3 indicating moderate disability, 4 indicating moderately severe disability, and 5 indicating severe disability. To ensure consistency and accuracy in questionnaire completion, the surveyors underwent standardized training to clarify principles and guidelines for filling out the questionnaire. The survey was conducted via telephone, and patients who did not answer calls on three separate occasions at different times were considered lost to follow-up.\u003c/p\u003e \u003cp\u003e \u003cstrong\u003eStatistical Analysis\u003c/strong\u003e \u003cp\u003eThe data were analyzed using SPSS 23.0 software. Categorical variables were presented as number (percentage) while continuous variables were reported as mean and standard deviation (SD). Univariate analysis utilized chi-square tests and rank-sum tests, and multivariate analysis was performed using Logistic regression. Spearman correlation analysis was employed to explore the relationships between disability severity and awareness, participation, and satisfaction rates. A significance level of p\u0026thinsp;\u0026lt;\u0026thinsp;0.05 was considered statistically significant.\u003c/p\u003e \u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e \u003cstrong\u003eBasic Information\u003c/strong\u003e \u003cp\u003eIn the 1098 valid samples, the average age was 63.79\u0026thinsp;\u0026plusmn;\u0026thinsp;10.95 years. Among them, there were 677 males (61.66%) and 421 females (38.34%). Urban residents accounted for 51.55%, Table\u0026nbsp;1.\u003c/p\u003e \u003c/p\u003e \u003cp\u003e \u003cstrong\u003eDisease Characteristics and Disability Status\u003c/strong\u003e \u003cp\u003eThe main type of stroke was ischemic, accounting for 867 cases (78.96%), while hemorrhagic stroke occurred in 231 cases (21.04%). There were 195 cases with a history of stroke (17.76%). The prevalence of hypertension was 54.19%, and the prevalence of diabetes was 25.32% (Table\u0026nbsp;1). According to the mRS score, 170 individuals had slight disability (15.48%), 95 had moderate disability (8.65%), 90 had moderately severe disability (8.20%), and 65 had severe disability (5.92%).\u003c/p\u003e \u003c/p\u003e \u003cp\u003e \u003cstrong\u003eAwareness, participation, and satisfaction rates regarding rehabilitation\u003c/strong\u003e \u003cp\u003eIn 1098 stroke patients, the awareness rate and participation rate of stroke rehabilitation were 36.98% (n\u0026thinsp;=\u0026thinsp;406) and 27.87% (n\u0026thinsp;=\u0026thinsp;306). Among the patients who received rehabilitation treatment, 199 were satisfied(including fairly and quite satisfied), resulting in a satisfaction rate of 65.03%. A univariate analysis was conducted, revealing statistically significant differences (p\u0026thinsp;\u0026lt;\u0026thinsp;0.05) in the awareness and participation rates of rehabilitation among stroke patients based on various factors, including age, marital status, residential area, stroke type, stroke frequency, hypertension, and mRS score (Table\u0026nbsp;1). Additionally, statistically significant differences (p\u0026thinsp;\u0026lt;\u0026thinsp;0.05) in satisfaction with rehabilitation were observed among patients of different ages and mRS scores (Table\u0026nbsp;2). The significant variables identified in the univariate analysis were assigned as dependent variables. Logistic regression analyses were performed with awareness, participation, and satisfaction as separate dependent variables. The results indicated a significant correlation between age, stroke type, and mRS score with patients' awareness and participation in rehabilitation (p\u0026thinsp;\u0026lt;\u0026thinsp;0.05), as shown in Tables\u0026nbsp;3 and 4.\u003c/p\u003e \u003c/p\u003e \u003cp\u003e \u003cstrong\u003eThe relationship between disability and awareness, participation and satisfaction with stroke\u003c/strong\u003e \u003cp\u003eSpearman correlation analysis shows that the mRS score was positively correlated with awareness(r\u0026thinsp;=\u0026thinsp;0.635,P\u0026lt;0.001) and participation(r\u0026thinsp;=\u0026thinsp;0.589,P\u0026lt;0.001), but negatively correlated with satisfaction(r=-0.503,P\u0026lt;0.001), suggesting that patients with higher mRS scores had higher levels of awareness and participation, but lower levels of satisfaction.\u003c/p\u003e \u003c/p\u003e"},{"header":"Dicussion","content":"\u003cp\u003eThe results of this study indicate that the awareness rate of rehabilitation among stroke patients in the Xuzhou region is 36.98%, implying that less than half of the stroke patients are informed about stroke rehabilitation. This may be due to insufficient education about rehabilitation or a lack of awareness among patients regarding the importance of rehabilitation. The participation rate is 27.87%, which could be attributed, on one hand, to some patients perceiving their physical condition as satisfactory and not seeing the necessity for rehabilitation. On the other hand, it might be because some patients with severe disabilities remain skeptical about the effectiveness of rehabilitation, believing that the outcomes may not meet their expectations, leading to their non-participation. Finally, there are also patients who are unaware of the need for rehabilitation. The satisfaction rate is 65.03%, indicating that although a certain proportion of patients participated in rehabilitation, many are still dissatisfied with the rehabilitation process. This dissatisfaction may stem from rehabilitation plans that do not cater to their needs, insignificant rehabilitation outcomes, or a lack of adequate support and feedback. Enhancing awareness, participation, and satisfaction rates among stroke patients is crucial. This requires a series of measures, including improved promotion and education, personalized rehabilitation plans, additional feedback mechanisms, and possibly a more comprehensive healthcare system. Additionally, interdisciplinary teamwork should be strengthened, extending rehabilitation beyond rehabilitation medicine to fields such as neurology. Finally, establishing a comprehensive rehabilitation team comprising doctors, nurses, physical therapists, psychologists, and other professionals can better meet the diverse rehabilitation needs of patients.\u003c/p\u003e \u003cp\u003e It found that while rural stroke patients had higher awareness and participation rates, their satisfaction rates were lower than those of urban patients. This may be attributed to the more severe disability status of rural patients, their strong desire to receive training, but limited access to quality rehabilitation training due to the shortage of medical resources and economic reasons in rural areas. The survey found that many stroke patients living in rural areas received rehabilitation training at the county-level hospital or even at the township health center, which indicates that although rehabilitation medicine has developed rapidly in Xuzhou and has reached the township level on a large scale, it is not yet strong enough. This, to some extent, also reflects certain phenomena in the development of rehabilitation medicine in China.\u003c/p\u003e \u003cp\u003eAge, stroke type, and mRS (Modified Rankin Scale) score show significant correlations with patient awareness and participation in rehabilitation (p\u0026thinsp;\u0026lt;\u0026thinsp;0.05). Patients of different ages and mRS scores exhibit statistically significant differences in stroke rehabilitation satisfaction rates (p\u0026thinsp;\u0026lt;\u0026thinsp;0.05). Older patients tend to have lower awareness, participation, and satisfaction rates in stroke rehabilitation. Advanced age may be associated with less understanding of health management and rehabilitation concepts. As patients age, some may be less familiar or comfortable with modern technology, such as smartphones or computers, potentially affecting their ability to access rehabilitation information and leading to insufficient awareness of rehabilitation. Older patients may face physical limitations that hinder active participation in rehabilitation activities. Factors like pain, reduced mobility, or chronic conditions could impact their rehabilitation progress. Moreover, older patients may be more prone to feelings of anxiety, depression, or a negative attitude toward the rehabilitation process. Their rehabilitation needs may not be as strong as those of younger individuals, leading to lower levels of participation and satisfaction. Similar patterns may be observed among patients with varying degrees of disability. This study found that stroke patients with higher mRS (Modified Rankin Scale) scores have higher awareness and participation rates but lower satisfaction rates. This suggests that patients with more severe disabilities have higher expectations for improving their functional abilities, enhancing their quality of life, and reintegrating into family and society. However, due to the severity of their condition, unrealistic expectations, or insufficient understanding of rehabilitation, these expectations are not always met. Therefore, rehabilitation professionals and therapists must enhance their skills and provide education on rehabilitation knowledge to patients and their families, allowing for a better understanding of rehabilitation concepts.\u003c/p\u003e \u003cp\u003eThis study also has certain limitations. Firstly, it adopts a cross-sectional study design, where all data and information are collected simultaneously, limiting causal inferences. The study can only propose hypotheses regarding the factors related to the awareness, participation, and satisfaction rates of stroke patients in rehabilitation, without establishing causal relationships. Secondly, the study is a single-center research, which restricts the generalizability of the results, as there may be variations across different regions and medical institutions. Future research could employ more rigorous study designs for long-term follow-ups to delve deeper into the relationships among awareness, participation, and satisfaction rates of stroke patients in rehabilitation, as well as the associated factors.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eThe awareness, participation, and satisfaction levels of stroke patients regarding stroke rehabilitation remain less than ideal. Patients with higher levels of disability have a greater awareness of and participation in stroke rehabilitation. However, their satisfaction rates tend to be lower. Government should take measures to promote the high-quality development of rehabilitation medicine. Healthcare workers should strengthen education and dissemination of rehabilitation knowledge to help them better support patients and their families in establishing correct rehabilitation concepts. By taking these steps, we can improve the quality of life and outcomes for stroke patients.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003eAcknowledgments\u003c/p\u003e\n\u003cp\u003eThe authors would like to thank every patient and family member interviewed. We also appreciate the assistance provided by Mr. Shengli Li from the Clinical Research Institute of the Affiliated Hospital of Xuzhou Medical University in the fields of statistics and data analysis.\u003c/p\u003e\n\u003cp\u003eDisclosure statement\u003c/p\u003e\n\u003cp\u003eNo potential conflict of interest was reported by the author(s).\u003c/p\u003e\n\u003cp\u003eEthical statement\u003c/p\u003e\n\u003cp\u003eInformed consent was obtained from all individual participants included in this study, or from their legal guardians in cases where participants were minors or lacked decision-making capacity. The study protocol adhered to the ethical principles outlined in the Declaration of Helsinki. The Ethics Committee of the Affiliated Hospital of Xuzhou\u003c/p\u003e\n\u003cp\u003eMedical University approved this research (XYFY2021-KL269-01). This study was registered in the China Clinical Trials Registry (No. ChiCTR2100048154).\u003c/p\u003e\n\u003cp\u003eFunding\u003c/p\u003e\n\u003cp\u003eThis work was supported by National Key Research and Development Program of China (No.2020YFC2006604).\u003c/p\u003e\n\u003cp\u003eAvailability of data and materials\u003c/p\u003e\n\u003cp\u003eThe datasets used during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003eConflict of interest declaration\u003c/p\u003e\n\u003cp\u003eNo potential conflict of interest was reported by the author(s).\u003c/p\u003e\n\u003cp\u003eAuthors\u0026rsquo; Contributions\u003c/p\u003e\n\u003cp\u003eYang Huo: research design, data collection and analysis, and paper writing; Sijie Liang: research design; Quanqing Wei: data collection; Yunyun Zhang and Ting Zhang: paper writing; Jie Xiang: research design, paper guidance, and acquisition of research funds.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eBoursin P, Paternotte S, Dercy B, Sabben C, Ma\u0026iuml;er B. [Semantics, epidemiology and semiology of stroke]. Soins. 2018;63(828):24\u0026thinsp;\u0026minus;\u0026thinsp;7. Epub 2018/09/15. doi: 10.1016/j.soin.2018.06.008. PubMed PMID: 30213310.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eMukherjee D, Patil CG. Epidemiology and the global burden of stroke. World Neurosurg. 2011;76(6 Suppl):S85-90. Epub 2012/01/04. doi: 10.1016/j.wneu.2011.07.023. PubMed PMID: 22182277.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eGlobal, regional, and national burden of stroke, 1990\u0026ndash;2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(5):439\u0026thinsp;\u0026minus;\u0026thinsp;58. Epub 2019/03/16. doi: 10.1016/s1474-4422(19)30034-1. PubMed PMID: 30871944; PubMed Central PMCID: PMCPMC6494974.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eRigby H, Gubitz G, Phillips S. A systematic review of caregiver burden following stroke. Int J Stroke. 2009;4(4):285\u0026thinsp;\u0026minus;\u0026thinsp;92. Epub 2009/08/20. doi: 10.1111/j.1747-4949.2009.00289.x. PubMed PMID: 19689757.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eThors\u0026eacute;n AM, Holmqvist LW, de Pedro-Cuesta J, von Koch L. A randomized controlled trial of early supported discharge and continued rehabilitation at home after stroke: five-year follow-up of patient outcome. Stroke. 2005;36(2):297\u0026ndash;303. Epub 2004/12/25. doi: 10.1161/01.STR.0000152288.42701.a6. PubMed PMID: 15618441.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBright T, Wallace S, Kuper H. A Systematic Review of Access to Rehabilitation for People with Disabilities in Low- and Middle-Income Countries. Int J Environ Res Public Health. 2018;15(10). Epub 2018/10/04. doi: 10.3390/ijerph15102165. PubMed PMID: 30279358; PubMed Central PMCID: PMCPMC6210163.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eMcKevitt C, Fudge N, Redfern J, Sheldenkar A, Crichton S, Rudd AR, et al. Self-reported long-term needs after stroke. Stroke. 2011;42(5):1398\u0026thinsp;\u0026minus;\u0026thinsp;403. Epub 2011/03/29. doi: 10.1161/strokeaha.110.598839. PubMed PMID: 21441153.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eOvbiagele B, Goldstein LB, Higashida RT, Howard VJ, Johnston SC, Khavjou OA, et al. Forecasting the future of stroke in the United States: a policy statement from the American Heart Association and American Stroke Association. Stroke. 2013;44(8):2361-75. Epub 2013/05/24. doi: 10.1161/STR.0b013e31829734f2. PubMed PMID: 23697546.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLu J, Lu Y, Wang X, Li X, Linderman GC, Wu C, et al. Prevalence, awareness, treatment, and control of hypertension in China: data from 1\u0026middot;7\u0026nbsp;million adults in a population-based screening study (China PEACE Million Persons Project). Lancet. 2017;390(10112):2549-58. Epub 2017/11/06. doi: 10.1016/s0140-6736(17)32478-9. PubMed PMID: 29102084.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eKang SH, Kim SH, Cho JH, Yoon CH, Hwang SS, Lee HY, et al. Prevalence, Awareness, Treatment, and Control of Hypertension in Korea. Scientific Reports. 2019;9(1):10970. Epub 2019/07/31. doi: 10.1038/s41598-019-46965-4. PubMed PMID: 31358791; PubMed Central PMCID: PMCPMC6662850.\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Stroke, Rehabilitation, Survey","lastPublishedDoi":"10.21203/rs.3.rs-6586964/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6586964/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cb\u003eBackground\u003c/b\u003e\u003c/p\u003e \u003cp\u003ePost-Rehabilitation is crucial for the recovery of stroke patients after a stroke. However, current research lacks investigations into stroke patients' awareness of the need for rehabilitation after a stroke. Additionally, there is a shortage of studies assessing the satisfaction levels of stroke patients who have undergone rehabilitation.\u003c/p\u003e\u003cp\u003e\u003cb\u003eObjective\u003c/b\u003e\u003c/p\u003e \u003cp\u003eInvestigating the awareness, participation, and satisfaction of stroke patients in the Xuzhou Region regarding rehabilitation, with an analysis of relevant factors.\u003c/p\u003e\u003cp\u003e\u003cb\u003eMethod\u003c/b\u003e\u003c/p\u003e \u003cp\u003eA total of 1654 patients diagnosed with stroke at Xuzhou Medical University Affiliated Hospital between January 2021 and June 2022 were selected. Telephone follow-up interviews were conducted with these patients six months to one year after their discharge to collect information.\u003c/p\u003e\u003cp\u003e\u003cb\u003eResults\u003c/b\u003e\u003c/p\u003e \u003cp\u003eAmong 1654 patients, 219 were lost to follow-up, and 337 died. There were 1098 valid samples. Among these, 406 patients (36.98%) were aware that stroke required rehabilitation, 306 patients (27.87%) participated in rehabilitation, and 146 (47.71%) were relatively satisfied with rehabilitation, and 53 (17.32%) were satisfied. There was a positive correlation between mRS score and awareness rate (r\u0026thinsp;=\u0026thinsp;0.635, p\u0026thinsp;\u0026lt;\u0026thinsp;0.001), as well as between mRS score and participation rate (r\u0026thinsp;=\u0026thinsp;0.589, p\u0026thinsp;\u0026lt;\u0026thinsp;0.001). Conversely, mRS score exhibited a negative correlation with satisfaction rate (r=-0.503, p\u0026thinsp;\u0026lt;\u0026thinsp;0.001).\u003c/p\u003e\u003cp\u003e\u003cb\u003eConclusion\u003c/b\u003e\u003c/p\u003e \u003cp\u003eThe awareness, participation, and satisfaction levels of stroke patients regarding post-stroke rehabilitation remain less than ideal. Patients with higher levels of disability have a greater awareness of and participation in post-stroke rehabilitation. However, their satisfaction rates tend to be lower.\u003c/p\u003e","manuscriptTitle":"Survey and Analysis of Awareness, Participation, and Satisfaction Rate of Stroke Patients in the Xuzhou Region regarding Rehabilitation and Related Factors","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-06-30 07:39:55","doi":"10.21203/rs.3.rs-6586964/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2025-07-22T07:04:30+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-07-12T07:54:48+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-07-07T03:40:10+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"71109040706355810833969761050994377721","date":"2025-06-30T03:03:46+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"186254449349508865840399332243340745972","date":"2025-06-26T17:58:53+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-06-26T10:11:28+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-06-25T16:50:04+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2025-05-21T15:36:38+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-05-12T11:04:04+00:00","index":"","fulltext":""},{"type":"submitted","content":"Scientific Reports","date":"2025-05-12T11:02:59+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"ca7eb166-4770-43eb-bc62-9e6610c881bd","owner":[],"postedDate":"June 30th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[{"id":50736955,"name":"Health sciences/Diseases"},{"id":50736956,"name":"Health sciences/Health care"},{"id":50736957,"name":"Health sciences/Medical research"},{"id":50736958,"name":"Health sciences/Risk factors"}],"tags":[],"updatedAt":"2025-08-14T05:08:25+00:00","versionOfRecord":[],"versionCreatedAt":"2025-06-30 07:39:55","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6586964","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6586964","identity":"rs-6586964","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}

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