Development and trend of stem cell therapy for diabetes: A comprehensive review based on Knowledge visualization analysis.

Development and trend of stem cell therapy for diabetes: A comprehensive review based on Knowledge visualization analysis. | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Development and trend of stem cell therapy for diabetes: A comprehensive review based on Knowledge visualization analysis. XINYU HUANG, QINGGUANG CHEN, HAO LU This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8461181/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract This study conducted a comprehensive analysis of the literature in the field of stem cell therapy for diabetes from 1995 to 2025 using CiteSpace, VOSviewer, and the "bibliometrix" R package. The research focused on the distribution of countries/regions, institutions, and authors in this field, and analyzed current research hotspots and future development trends by reviewing key academic achievements and highly co-cited literature. The results show that research on stem cell therapy for diabetes is moving toward more refined cell engineering, particularly with significant progress in the study of β-cell maturation and differentiation mechanisms. Future research will place greater emphasis on the development of immune evasion technologies, including the design of novel biocompatible encapsulation materials and the exploration of local immune modulation strategies. Additionally, mesenchymal stem cells and their exosomes, as well as other acellular products, show great potential in immune regulation and regeneration, opening up broad prospects for the treatment of diabetes complications. The study also points out that stem cell therapy for diabetes has reached a critical turning point, from proof-of-concept to clinical solutions. Future breakthroughs will rely on the deep integration of cell biology, immunology, genetic engineering, and clinical medicine to address fundamental issues related to cell function, immune rejection, and long-term safety, providing safer, more effective, and universally applicable therapeutic strategies for the functional cure of diabetes. Diabetes stem cell therapy bibliometric analysis visualized knowledge mapping Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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