The relationship between CYP19A1 gene expression in luteinized granulosa cells and follicular estradiol output in women with endometriosis

Giacomini, Elisa, Pagliardini, Luca, Minetto, Sabrina, Pinna, Monica, Kleeman, Fabiola, Bonesi, Francesca, Makieva, Sofia, Pavone, Valentina, Reschini, Marco, Papaleo, Enrico, Candiani, Massimo, Somigliana, Edgardo, Viganò, Paola
2024 · doi:10.5167/uzh-253838 · W6948516626
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

This study assessed CYP19A1, StAR, and 3βHSD gene expression in luteinized granulosa cells to investigate ovarian steroidogenesis in women with endometriosis.

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This study examined whether endometriosis alters the intrafollicular environment by measuring gene expression of CYP19A1 (aromatase) and upstream steroidogenic enzymes StAR and 3βHSD in luteinized granulosa cells, and relating these measures to follicular estradiol output in women with endometriosis. It built on prior work showing conflicting findings about CYP19A expression in granulosa and cumulus oophorus cells in endometriosis by focusing on gene expression in luteinized granulosa cells. A key limitation stated by the authors is that earlier studies have produced controversial results, motivating a need to clarify steroidogenic regulation in this specific cellular context. This paper is centrally about endometriosis — it links CYP19A1 gene expression in luteinized granulosa cells to follicular estradiol output in women with endometriosis.

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Abstract

Abstract

Abstract

Endometriosis was claimed to negatively affect the intrafollicular environment, hindering oocyte competence. Previous studies evaluated expression levels of cytochrome P450 aromatase (CYP19A) in granulosa and cumulus oophorus cells collected from endometriosis women, but results are controversial. To further investigate the intrafollicular environment whose alteration may potentially disturb ovarian steroidogenesis in endometriosis, gene expression of CYP19A and of its upstream enzymes, StAR and 3βHSD was assessed in luteinized granul Metrics Downloads Views Additional indexing Creators (Authors) Journal/Series Title Journal/Series Title Journal/Series Title Volume Volume Volume Page range/Item number Page range/Item number Page range/Item number Item Type Item Type Item Type In collections Dewey Decimal Classifikation Dewey Decimal Classifikation Dewey Decimal Classifikation

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Language Language Language Publication date Publication date Publication date Date available Date available Date available ISSN or e-ISSN ISSN or e-ISSN ISSN or e-ISSN OA Status OA Status OA Status Publisher DOI Metrics Downloads Views Citations Giacomini, E., Pagliardini, L., Minetto, S., Pinna, M., Kleeman, F., Bonesi, F., Makieva, S., Pavone, V., Reschini, M., Papaleo, E., Candiani, M., Somigliana, E., & Viganò, P. (2024). The relationship between CYP19A1 gene expression in luteinized granulosa cells and follicular estradiol output in women with endometriosis. Journal of Steroid Biochemistry and Molecular Biology, 237, 106439. https://doi.org/10.1016/j.jsbmb.2023.106439

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endometriosis

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