Dual Modulation Of Cyp3a4 And P-Gp By Natural Bioenhancers For Oral Paclitaxel Delivery

Dual Modulation Of Cyp3a4 And P-Gp By Natural Bioenhancers For Oral Paclitaxel Delivery | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 21 July 2025 V1 Latest version Share on Dual Modulation Of Cyp3a4 And P-Gp By Natural Bioenhancers For Oral Paclitaxel Delivery Author : Dan Korsby 0009-0008-4208-9097 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.175312599.95581828/v1 201 views 101 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Paclitaxel, a potent chemotherapeutic agent, exhibits poor oral bioavailability due to its extensive metabolism by cytochrome P450 3A4 (CYP3A4) and active efflux by P-glycoprotein (P-gp). Dual modulation of these barriers is critical to enhance its systemic absorption via the oral route. Natural bioenhancers, particularly phytochemicals such as piperine, quercetin, curcumin, and resveratrol, have emerged as promising modulators of both CYP3A4 and P-gp. These compounds can inhibit the enzymatic activity of CYP3A4 and reduce P-gp-mediated efflux, thereby improving the pharmacokinetic profile of paclitaxel. This review explores the mechanistic roles of selected natural bioenhancers in modulating drug-metabolizing enzymes and efflux transporters. It also discusses current advancements in formulation strategies integrating these bioenhancers to develop efficient oral delivery systems for paclitaxel. The dual inhibition approach holds significant promise in overcoming the pharmacological barriers associated with oral chemotherapy, potentially reducing the need for intravenous administration and enhancing patient compliance. Supplementary Material File (dual modulation of cyp3a4 and p-gp by natural bioenhancers for oral paclitaxel delivery.pdf) Download 305.12 KB Information & Authors Information Version history V1 Version 1 21 July 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords bioenhancers drug metabolism oral drug delivery p-glycoprotein (p-gp) phytochemicals Authors Affiliations Dan Korsby 0009-0008-4208-9097 [email protected] View all articles by this author Metrics & Citations Metrics Article Usage 201 views 101 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Dan Korsby. Dual Modulation Of Cyp3a4 And P-Gp By Natural Bioenhancers For Oral Paclitaxel Delivery. Authorea . 21 July 2025. DOI: https://doi.org/10.22541/au.175312599.95581828/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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