PRE-IVF PRETREATMENT WITH A GnRH ANTAGONIST IN WOMEN WITH ENDOMETRIOSIS: CLINICAL AND REPRODUCTIVE OUTCOMES

К.О. Каримова, М.М. Максудова, У.А. Ашурова, M.B. Alieva
2026 · doi:10.5281/zenodo.22844408 · W7213624357
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This paper reviews the controversy surrounding pre-IVF pretreatment with GnRH antagonists in women with endometriosis, noting that the disease negatively influences reproductive stages such as folliculogenesis and implantation.

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This paper addresses the management of infertility associated with endometriosis, a chronic estrogen-dependent inflammatory disease that negatively impacts folliculogenesis, oocyte competence, and implantation. The text highlights that reproductive consequences are particularly severe in advanced-stage disease and when ovarian endometriomas reduce ovarian reserve during controlled stimulation. It notes that current strategies for pretreating these patients before in vitro fertilization remain controversial due to the complex influence of the disease on various stages of the reproductive process. This paper is centrally about endometriosis — specifically focusing on its impact on fertility and the controversy surrounding pre-IVF treatment protocols.

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Abstract

Endometriosis is a chronic estrogen-dependent inflammatory disease that affects women of reproductive age and is strongly associated with infertility. In women referred for assisted reproductive technologies (ART), endometriosis may negatively influence several stages of the reproductive process, including folliculogenesis, oocyte competence, embryo development, endometrial receptivity and implantation.[5] The reproductive consequences are particularly relevant in advanced-stage disease and in the presence of ovarian endometriomas, which may be accompanied by a reduction in ovarian reserve and a lower oocyte yield during controlled ovarian stimulation. The management of endometriosis-associated infertility before in vitro fertilization (IVF) remains controversial.
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| Endometriosis is a chronic estrogen-dependent inflammatory disease that affects women of reproductive age and is strongly associated with infertility. In women referred for assisted reproductive technologies (ART), endometriosis may negatively influence several stages of the reproductive process, including folliculogenesis, oocyte competence, embryo development, endometrial receptivity and implantation.[5] The reproductive consequences are particularly relevant in advanced-stage disease and in the presence of ovarian endometriomas, which may be accompanied by a reduction in ovarian reserve and a lower oocyte yield during controlled ovarian stimulation. The management of endometriosis-associated infertility before in vitro fertilization (IVF) remains controversial. |

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