Hydroxyapatite nanoparticles as a vehicle for drug delivery approach in Alzheimer's disease

Hydroxyapatite nanoparticles as a vehicle for drug delivery approach in Alzheimer's disease | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 29 August 2025 V1 Latest version Share on Hydroxyapatite nanoparticles as a vehicle for drug delivery approach in Alzheimer's disease Authors : Osaid Rizvi SM , Akrish Thakur , Sakshi Sharma , Harsimran Kaur , Sukhmanpreet Kaur , and Pallavi Dan 0000-0002-5814-2912 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.175647833.34740198/v1 433 views 226 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Hydroxyapatite (HAp) nanoparticles are emerging as a promising drug delivery vehicle for Alzheimer’s Disease (AD) treatment due to their biocompatibility , stability , & surface versatility. AD is a progressive neurodegenerative condition characterized by cognitive decline, primarily driven by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Current treatment options predominantly address symptoms and face significant limitations, particularly in crossing the blood-brain barrier, prompting interest in nanoparticle-based delivery systems. Its nanoscale size offers a high surface area, enabling greater drug-loading capacity and controlled, targeted drug release. Additionally, the surface of HAp nanoparticles can be functionalized with ligands, antibodies, to facilitate specific binding to BBB endothelial cell receptors, improving drug transport into brain tissue. This targeted delivery approach not only enhances drug bioavailability but also reduces side effects commonly associated with conventional AD therapies. Supplementary Material File (updated hap_paper.docx) Download 1.83 MB Information & Authors Information Version history V1 Version 1 29 August 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords alzheimer’s disease biomaterials bionanotechnology blood brain barrier hydroxyapatite (hap) nanobiotechnology neurobiology Authors Affiliations Osaid Rizvi SM Chandigarh University View all articles by this author Akrish Thakur Chandigarh University View all articles by this author Sakshi Sharma Chandigarh University View all articles by this author Harsimran Kaur Chandigarh University View all articles by this author Sukhmanpreet Kaur Chandigarh University View all articles by this author Pallavi Dan 0000-0002-5814-2912 [email protected] Chandigarh University View all articles by this author Metrics & Citations Metrics Article Usage 433 views 226 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Osaid Rizvi SM, Akrish Thakur, Sakshi Sharma, et al. Hydroxyapatite nanoparticles as a vehicle for drug delivery approach in Alzheimer's disease. Authorea . 29 August 2025. 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