Association between Estradiol and Bone Mineral Density in Adults Aged 40-60 years

Background: The purpose of this analysis was to explore the relationship between estradiol and total bone mineral density (BMD) in American adults aged 40 to 60 years. Methods: We used a cross-sectional study. Data for the study came from the National Health and Nutrition Examination Survey (NHANES) . The study examined data from a sample of the American population. Results: Data analysis showed a significant association between estradiol levels and total bone mineral density in US adults aged 40 to 60 years. When estradiol levels were below the threshold of 33.3pg/mL, estradiol was positively associated with total BMD in all ethnic groups. There was no significant correlation between estradiol levels above the threshold of 33.3pg/mL. When estradiol levels in men were below the threshold of 40.3pg/mL, estradiol was positively correlated with total BMD. When estradiol levels in women were below the threshold of 25pg/mL, estradiol was positively correlated with total BMD. Conclusions: In the 40-60 year old population, when estradiol level is at a lower concentration, estradiol level is positively correlated with total BMD. Increasing estradiol level can promote bone health. When estradiol levels are at higher concentrations, changes in estradiol levels may have no significant effect on bone health.