Vaginal agenesis and vaginal dilation: an individualized approach using three-dimensional (3D) printer molds.

Abstract Objective: The aim of this study was to evaluate the use of vaginal molds, made with three-dimensional (3D) printing, for conservative treatment through vaginal dilation in patients with Vaginal Agenesis (VA). Methods: Sixteen patients with a diagnosis of VA (Mayer-Rokitansky-Küster-Hauser syndrome, Total Androgen Insensitivity Syndrome and cervicovaginal agenesis), from Federal University of São Paulo, were selected. The production of the devices was carried out in a 3D printer and, as raw material, the polymeric filament of the lactic polyacid (PLA) was used. A personalized treatment was proposed and developed for each patient.Results: Fourteen patients reached a final vaginal length of 6 cm or more. The initial TVL Mean (SD) was 1,81(1,05) and the final TVL Mean (SD) 6,37(0,94); the Difference (IC-95%) was 4,56 (5,27 - 3,84) and the Effect size (IC-95%) was 4,58 (2,88 – 6,28). Therefore, there was a significant difference (P<0.05) between the initial and final measurements. The Effect Size was 4.58, reinforcing the great magnitude of this difference. Conclusion: The present study has shown the fruitful applicability of the devices, which offers an economical, accessible, promissing and reproducible strategy for the treatment of VA.