Trends and Disparities in Atrial Fibrillation-Related Mortality Among Older Adults with Parkinson's Disease in the United States, 2000--2023

Trends and Disparities in Atrial Fibrillation-Related Mortality Among Older Adults with Parkinson's Disease in the United States, 2000--2023 | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 20 September 2025 V1 Latest version Share on Trends and Disparities in Atrial Fibrillation-Related Mortality Among Older Adults with Parkinson's Disease in the United States, 2000--2023 Authors : Mohid Zulfiqar 0009-0004-4099-4094 , Syed Ahmed Ali Shah 0009-0000-1224-6372 , Asim Sajjad 0009-0002-2121-7770 , Muhammad Tahir , Wasay Mumtaz Awan , Muhammad Ahmed 0009-0002-5578-2022 , and Raheel Ahmed [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.175839134.42853264/v1 Published Journal of Arrhythmia Version of record Peer review timeline 260 views 142 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: The coexistence of parkinson’s disease (PD) and atrial fibrillation (AF) is increasingly recognized, but the mortality burden and disparities among affected individuals remain poorly characterized. Objective: This study aimed to analyze 24-year trends, demographic patterns, and geographic disparities in AF-related mortality among US older adults with PD. Methods: We conducted a population-based analysis using CDC WONDER Multiple Cause of Death data from 2000 to 2023. Age-adjusted mortality rates (AAMRs) were calculated for adults aged ≥65 with both AF and PD listed as causes of death. Trends were analyzed using Joinpoint regression to compute annual percentage changes (APCs). Results: AAMRs increased from 3.1 to 8.2 per 100,000, with a significant acceleration from 2015–2021 (APC: +10.7%) before declining. Mortality was consistently higher in men than women. Non-Hispanic White adults had the highest overall AAMR (5.6), while Hispanic adults exhibited the steepest upward trend (APC: +6.8%). Pronounced geographic disparities existed, with the highest mortality in the Western US and nonmetropolitan areas. State-level AAMRs varied nearly fourfold. Conclusion: AF-related mortality among older adults with PD has risen substantially, marked by significant sex, racial, and geographic disparities. These findings underscore the urgent need for targeted interventions and integrated care models to mitigate risks in this vulnerable population. Supplementary Material File (figures parkinsons and af.docx) Download 523.90 KB File (manuscript of parkinson and af.docx) Download 277.57 KB Information & Authors Information Version history V1 Version 1 20 September 2025 Peer review timeline Published Journal of Arrhythmia Version of Record 12 Mar 2026 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords basic: atrial fibrillation/atrial arrhythmias clinical: electrophysiology – atrial arrhythmias clinical: electrophysiology – conduction disturbances clinical: epidemiology/clinical trials clinical: pediatrics – electrophysiology Authors Affiliations Mohid Zulfiqar 0009-0004-4099-4094 Dow University of Health Sciences View all articles by this author Syed Ahmed Ali Shah 0009-0000-1224-6372 Dow Medical College View all articles by this author Asim Sajjad 0009-0002-2121-7770 Dow University of Health Sciences View all articles by this author Muhammad Tahir Dow University of Health Sciences View all articles by this author Wasay Mumtaz Awan Dow University of Health Sciences View all articles by this author Muhammad Ahmed 0009-0002-5578-2022 Dow University of Health Sciences View all articles by this author Raheel Ahmed [email protected] Imperial College London National Heart and Lung Institute View all articles by this author Metrics & Citations Metrics Article Usage 260 views 142 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Mohid Zulfiqar, Syed Ahmed Ali Shah, Asim Sajjad, et al. Trends and Disparities in Atrial Fibrillation-Related Mortality Among Older Adults with Parkinson's Disease in the United States, 2000--2023. Authorea . 20 September 2025. DOI: https://doi.org/10.22541/au.175839134.42853264/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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